Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about CEREBRAL ISCHEMIA-REPERFUSION INJURY: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | CEREBRAL ISCHEMIA-REPERFUSION INJURY |
| Key Genes/Proteins | AMPK |
Knowledge base pages for this entity
graph TD
CEREBRAL_ISCHEMIA_REPERFUSION_["CEREBRAL ISCHEMIA-REPERFUSION INJURY"]
Tat_NTS["Tat-NTS"] -.protects against.-> CEREBRAL_ISCHEMIA_REPERFUSION_
ANXA1["ANXA1"] -.protects against.-> CEREBRAL_ISCHEMIA_REPERFUSION_
Gomisin_N["Gomisin N"] -.protects against.-> CEREBRAL_ISCHEMIA_REPERFUSION_
ANNEXIN_A1["ANNEXIN A1"] -.protects against.-> CEREBRAL_ISCHEMIA_REPERFUSION_
BDNF["BDNF"] -.protects against.-> CEREBRAL_ISCHEMIA_REPERFUSION_
ROS_reduction["ROS reduction"] -.prevents.-> CEREBRAL_ISCHEMIA_REPERFUSION_
TRIM25["TRIM25"] -->|"causes"| CEREBRAL_ISCHEMIA_REPERFUSION_
Microglia_Macrophage_Polarizat["Microglia/Macrophage Polarization"] -->|"involved_in"| CEREBRAL_ISCHEMIA_REPERFUSION_| Target | Relation | Type | Str |
|---|---|---|---|
| NLRP3 | upregulates | gene | 0.92 |
| Il-1Β | upregulates | protein | 0.92 |
| Inflammation | causes | process | 0.90 |
| Apoptosis | causes | process | 0.90 |
| mitochondrial dysfunction | causes | phenotype | 0.90 |
| MICROGLIA | activates | cell_type | 0.80 |
| Source | Relation | Type | Str |
|---|---|---|---|
| AMPK | protects_against | protein | 0.85 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||