gene

TRIM25

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about TRIM25: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

112Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

Summary

TRIM25 is an E3 ubiquitin ligase involved in innate immunity, mitochondrial quality control, and has been implicated in Parkinson's disease pathogenesis through regulation of mitophagy.

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🧬 Gene Info

Gene Symbol	TRIM25
Full Name	TRIM25 (Tripartite Motif Containing 25)
Chromosome	17q11.2
Protein Type	Gene
Function	encodes an E3 ubiquitin ligase that plays critical roles in multiple cellular processes including innate immunity, mitochondrial dynamics, and protein quality control.
Subcellular Localization	and activity
Molecular Weight	55 kDa
Amino Acids	504 aa
Exons	6
Pathways	Mitophagy
UniProt ID	Q9C0B1
NCBI Gene ID	11067
Ensembl ID	ENSG00000120937
OMIM	606112
GeneCards	TRIM25
Human Protein Atlas	TRIM25
Associated Diseases	cerebral ischemia-reperfusion injury
Interactions	PINK1, BRCA2, EGFR, HOXA10-HOXA9, BNIP3, NFKBIA
KG Connections	112 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: TRIM25 — AlphaFold Q9C0B1 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (6)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    TRIM25["<b>TRIM25</b>"]
    ATAD3A["ATAD3A"]
    TRIM25 -->|"modifies"| ATAD3A
    PINK1_Parkin_signaling_pathway(["PINK1/Parkin signaling pathway"])
    TRIM25 -->|"activates"| PINK1_Parkin_signaling_pathway
    cerebral_ischemia_reperfusion_injury{"cerebral ischemia-reperfusion injury"}
    TRIM25 -->|"causes"| cerebral_ischemia_reperfusion_injury
    Ischemia{"Ischemia"}
    TRIM25 -->|"regulates"| Ischemia
    Carcinoma{"Carcinoma"}
    TRIM25 -->|"activates"| Carcinoma
    Ms{"Ms"}
    TRIM25 -->|"activates"| Ms
    Tumor{"Tumor"}
    TRIM25 -->|"activates"| Tumor
    Cancer{"Cancer"}
    TRIM25 -->|"activates"| Cancer
    TRIM25 -->|"expressed in"| Carcinoma
    TRIM25 -->|"therapeutic target"| Tumor
    PINK1["PINK1"]
    TRIM25 -->|"activates"| PINK1
    Proteasome(["Proteasome"])
    TRIM25 -->|"interacts with"| Proteasome
    MITOPHAGY["MITOPHAGY"]
    MITOPHAGY -->|"activates"| TRIM25
    PARKIN["PARKIN"]
    PARKIN -->|"activates"| TRIM25
    P62["P62"]
    P62 -->|"associated with"| TRIM25
    LC3["LC3"]
    LC3 -->|"activates"| TRIM25
    LC3B["LC3B"]
    LC3B -->|"activates"| TRIM25
    P62 -->|"activates"| TRIM25
    MECOM["MECOM"]
    MECOM -->|"activates"| TRIM25
    OXIDATIVE_STRESS["OXIDATIVE STRESS"]
    OXIDATIVE_STRESS -->|"activates"| TRIM25
    style TRIM25 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (58)

Target	Relation	Type	Str
ATAD3A	modifies	protein	0.95
PINK1/Parkin signaling pathway	activates	pathway	0.90
ATAD3A	associated_with	protein	0.90
NFKBIA	degrades	protein	0.90
cerebral ischemia-reperfusion injury	causes	disease	0.85
NFKBIA	mediates	protein	0.85
Ischemia	regulates	disease	0.65
Carcinoma	activates	disease	0.65
Ms	activates	disease	0.65
Tumor	activates	disease	0.65
Cancer	activates	disease	0.65
Carcinoma	expressed_in	disease	0.65
Tumor	therapeutic_target	disease	0.65
Ms	regulates	disease	0.65
Traumatic Brain Injury	regulates	disease	0.65
Aging	inhibits	disease	0.65
Senescence	inhibits	disease	0.65
PINK1	activates	gene	0.60
BRCA2	activates	gene	0.60
EGFR	activates	gene	0.60
HOXA10-HOXA9	activates	gene	0.60
NRF2	expressed_in	gene	0.60
KEAP1	expressed_in	gene	0.60
BNIP3	regulates	gene	0.60
ubiquitination	inhibits	process	0.60
UBE3A	regulates	gene	0.60
VCP	regulates	gene	0.60
Proteasome	interacts_with	pathway	0.60
Mitophagy	activates	pathway	0.60
AUTOPHAGY	activates	gene	0.60
Autophagy	activates	pathway	0.60
SPINK1	activates	gene	0.60
CANCER	activates	gene	0.60
Er Stress	activates	pathway	0.60
Oxidative Stress	activates	pathway	0.60
MITOCHONDRIAL DYSFUNCTION	regulates	gene	0.60
Mitophagy	regulates	pathway	0.60
MITOPHAGY	regulates	gene	0.60
AND	regulates	gene	0.60
ALZHEIMER	regulates	gene	0.60
Ubiquitin	regulates	protein	0.60
Fus	regulates	protein	0.60
NF-kB signaling	participates_in	pathway	0.60
ubiquitin-proteasome	participates_in	pathway	0.60
traumatic brain injury	inhibits	disease	0.60
autophagy pathway	participates_in	pathway	0.60
CRISPR-Cas	participates_in	pathway	0.60
PI3K-AKT-mTOR signaling	participates_in	pathway	0.60
necroptosis	participates_in	pathway	0.60
oxidative stress response	participates_in	pathway	0.60

Incoming (54)

Source	Relation	Type	Str
PARKIN	activates	gene	0.60
P62	associated_with	gene	0.60
LC3	activates	gene	0.60
P62	activates	gene	0.60
MECOM	activates	gene	0.60
PINK1	activates	gene	0.60
EGFR	activates	gene	0.60
FOXO3	activates	gene	0.60
UBIQUITIN	activates	gene	0.60
GLUL	activates	gene	0.60
BNIP3	regulates	gene	0.60
NFKBIA	activates	gene	0.60
ISG15	regulates	gene	0.60
PARKIN	degrades	gene	0.60
HERC5	regulates	gene	0.60
DRP1	degrades	gene	0.60
BNIP3	inhibits	gene	0.60
NFKBIA	inhibits	gene	0.60
KEAP1	inhibits	gene	0.60
NRF2	inhibits	gene	0.60
APOE	inhibits	gene	0.60
ATAD3A	activates	gene	0.60
ATAD3A	expressed_in	gene	0.60
P62	expressed_in	gene	0.60
PINK1	expressed_in	gene	0.60
ATAD3A	regulates	gene	0.60
ATAD3A	interacts_with	gene	0.60
HUWE1	regulates	gene	0.60
PERK	activates	gene	0.60
PI3K	activates	gene	0.60
PTEN	activates	gene	0.60
RIPK1	activates	gene	0.60
TNF	activates	gene	0.60
TNFAIP3	activates	gene	0.60
TRAF6	activates	gene	0.60
MITOPHAGY	activates	gene	0.60
LC3B	activates	gene	0.60
OXIDATIVE STRESS	activates	gene	0.60
AND	expressed_in	gene	0.60
SPINK1	activates	gene	0.60
AND	activates	gene	0.60
CANCER	activates	gene	0.60
MITOPHAGY	regulates	gene	0.60
BRAIN INJURY	regulates	gene	0.60
MITOCHONDRIA	regulates	gene	0.60
NFKB	regulates	gene	0.60
AND	regulates	gene	0.60
MITOCHONDRIAL DYSFUNCTION	regulates	gene	0.60
MTDNA	regulates	gene	0.60
NFKB	inhibits	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

TRIM25

Understanding Entity Pages

Summary

Wiki Pages (6)

TRIM25 Gene (Tripartite Motif Containing 25)

GLUL — Glutamine Synthetase

ZC3HAV1 Protein

MECOM Gene

ISG15 Protein — Interferon-Stimulated Gene 15