concept

NF-KB

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NF-KB: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1604Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

NF-KB is a concept in neurodegeneration research. Key relationships include: activates, associated with, regulates. Associated with ALS, ALZHEIMER'S DISEASE, Aging. Connected to 482 entities in the SciDEX knowledge graph.

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💡 Concept Info

Name	NF-KB
Key Genes/Proteins	TNF-Α, TNF, TLR4, PI3K, NLRP3, NRF2
Related Diseases	Inflammation, PARKINSON'S DISEASE
Related Pathways	Nf-Kb

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

flowchart TD
    NF_KB(["NF-KB"])
    Nf_Kb["Nf-Kb"]
    Inflammation["Inflammation"]
    TNF__(["TNF-Alpha"])
    TNF(["TNF"])
    PARKINSON_S_DISEASE["PARKINSON'S DISEASE"]
    OXIDATIVE_STRESS["OXIDATIVE STRESS"]
    APOPTOSIS(["APOPTOSIS"])
    NEURODEGENERATION(["NEURODEGENERATION"])
    MICROGLIA["/"MICROGLIA"/"]
    NEUROINFLAMMATION["NEUROINFLAMMATION"]
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"]
    AKT(["AKT"])
    CANCER(["CANCER"])

    NF_KB -->|"activates"| Nf_Kb
    NF_KB -->|"activates"| Inflammation
    NF_KB -->|"activates"| TNF__
    NF_KB -->|"associated with"| TNF
    NF_KB -->|"associated with"| PARKINSON_S_DISEASE
    NF_KB -->|"associated with"| OXIDATIVE_STRESS
    TNF -->|"activates"| NF_KB
    APOPTOSIS -->|"associated with"| NF_KB
    NEURODEGENERATION -->|"associated with"| NF_KB
    MICROGLIA -->|"associated with"| NF_KB
    NEUROINFLAMMATION -->|"associated with"| NF_KB
    ALZHEIMER_S_DISEASE -->|"associated with"| NF_KB
    AKT -->|"associated with"| NF_KB
    NF_KB -->|"regulates"| Nf_Kb
    NF_KB -->|"activates"| CANCER

    style NF_KB fill:#006494,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (732)

Target	Relation	Type	Str
Nf-Kb	activates	pathway	1.00
Inflammation	activates	disease	1.00
TNF-Α	activates	gene	1.00
HIPPOCAMPUS	associated_with	brain_region	1.00
MACROPHAGE	associated_with	cell_type	1.00
TNF	associated_with	gene	1.00
TLR4	associated_with	gene	1.00
PI3K	associated_with	gene	1.00
CORTEX	associated_with	brain_region	1.00
NEURON	associated_with	cell_type	1.00
NLRP3	associated_with	gene	1.00
PARKINSON'S DISEASE	associated_with	disease	1.00
NRF2	associated_with	gene	1.00
MAPK	associated_with	gene	1.00
TAU	associated_with	protein	1.00
MULTIPLE SCLEROSIS	associated_with	disease	1.00
Nf-Kb	regulates	pathway	1.00
CANCER	activates	gene	1.00
JAK	associated_with	gene	0.98
C3	associated_with	gene	0.98
GFAP	associated_with	protein	0.98
DEMENTIA	associated_with	disease	0.98
INOS	associated_with	gene	0.96
Cancer	activates	disease	0.95
Neuroinflammation	activates	disease	0.95
Inflammation	regulates	disease	0.95
Alzheimer's Disease	involved_in	disease	0.95
STROKE	associated_with	disease	0.90
SIRT1	associated_with	gene	0.90
UBIQUITIN	associated_with	protein	0.90
DEPRESSION	associated_with	disease	0.90
STAT3	associated_with	gene	0.90
Neurodegeneration	contributes_to	process	0.90
CCL20	regulates	protein	0.90
Cancer	contributes_to	disease	0.90
STAT3	interacts_with	pathway	0.90
NLRP3	activates	protein	0.90
Alzheimer's disease	fuels	disease	0.90
NEUROINFLAMMATION	activates	gene	0.90
Nf-Kb	inhibits	pathway	0.90
INFLAMMATION	regulates	gene	0.90
NEURON	inhibits	cell_type	0.86
NEURON	activates	cell_type	0.86
NEURON	interacts_with	cell_type	0.86
Neurodegeneration	therapeutic_target	disease	0.85
Als	activates	disease	0.85
Tumor	activates	disease	0.85
Neurodegeneration	activates	disease	0.85
Als	associated_with	disease	0.85
Als	therapeutic_target	disease	0.85

Incoming (872)

Source	Relation	Type	Str
TNF	activates	gene	1.00
APOPTOSIS	associated_with	gene	1.00
NEURODEGENERATION	associated_with	gene	1.00
MICROGLIA	associated_with	cell_type	1.00
ALZHEIMER'S DISEASE	associated_with	disease	1.00
IL-6	associated_with	gene	1.00
AKT	associated_with	gene	1.00
IL-1B	associated_with	gene	1.00
ASTROCYTES	associated_with	cell_type	1.00
AMPK	associated_with	gene	1.00
MTOR	associated_with	gene	1.00
CASP3	associated_with	gene	1.00
ERK	associated_with	gene	1.00
AMYLOID	associated_with	protein	1.00
ABLIM1	activates	protein	0.95
MACROPHAGES	activates	cell_type	0.95
B CELLS	activates	cell_type	0.95
P38	regulates	gene	0.90
ALS	associated_with	disease	0.90
NEURON	activates	cell_type	0.86
Reactive Microglia	expressed_in	cell_type	0.85
Astrocytes	expressed_in	cell_type	0.85
Curcumin	modulates	compound	0.85
JUN	associated_with	gene	0.82
BAX	associated_with	gene	0.82
APOE	associated_with	gene	0.82
LL37	modulates	protein	0.80
miR-93-5p	activates	entity	0.80
APP	associated_with	gene	0.80
HYPOXIA	activates	process	0.80
MUC1	upregulates	gene	0.80
C3/C3AR	activates	pathway	0.80
ANTHOCYANINS	inhibits	compound	0.80
STIGMASTEROL	inhibits	compound	0.80
AMPK	inhibits	gene	0.80
NEURODEGENERATION	activates	gene	0.80
NEURON	regulates	cell_type	0.72
ASTROCYTES	activates	cell_type	0.72
MIRNAS	regulates	gene	0.70
PI3K	activates	gene	0.70
APOPTOSIS	activates	gene	0.70
PI3K	regulates	gene	0.70
NEURODEGENERATION	therapeutic_target	gene	0.70
ALZHEIMER	therapeutic_target	gene	0.70
ERK	activates	gene	0.70
CYTOKINES	activates	gene	0.70
APOE	interacts_with	protein	0.70
Glutamate	interacts_with	compound	0.70
MAPT	interacts_with	protein	0.70
miRNA	regulates	biomarker	0.70

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

NF-KB

Understanding Entity Pages

Summary

Wiki Pages (20)

CBS/PSP Supplements Guide

GSK-3β in Neurodegeneration

TREM2 Microglial Signaling Pathway in Neurodegeneration

omega-3-fatty-acids-neurodegeneration

Melatonin for Tauopathy: Comprehensive Evidence Synthesis

Rapamycin ALS Trial - mTOR Inhibition for Amyotrophic Lateral Sclerosis

Coenzyme Q10 for Neurodegeneration

Spinal Cord Dorsal Horn Neurons

nlrc5-protein

vitamin-d-therapy-neurodegeneration

NACET (N-Acetylcysteine Ethyl Ester)

Gene-Mechanism-Therapy Causal Chains

Curcumin for Neurodegeneration

creatine-supplementation-neurodegeneration

Neuroinflammation-Mitochondria Crosstalk Pathway

Epigenetic-Metabolic Coupling: SIRT1 Activator + NAD+ Precursor

NF-kB Signaling Pathway in Neurodegeneration

DDX3X Gene