gene

DHX9

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DHX9: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

21Connections

0Hypotheses

0Analyses

17Outgoing

4Incoming

Summary

DHX9 is a gene implicated in neurodegeneration research. Key relationships include: therapeutic target, associated with, implicated in. Associated with Aging, Als, Autism. Connected to 22 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	DHX9
Full Name	DEAH-Box Helicase 9
Aliases	RNA helicase A, LBP, NDH2
Chromosome	1q25.3
Function	is a nucleic acid helicase that unwinds both DNA and RNA substrates.
Molecular Weight	140 kDa
Amino Acids	090 aa
UniProt ID	Q9NQZ2
NCBI Gene ID	1660
Ensembl ID	ENSG00000135829
OMIM	603115
GeneCards	DHX9
Human Protein Atlas	DHX9
ATR	Phosphorylation
AKT1	Physical interaction
Associated Diseases	neurodegeneration
KG Connections	21 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: DHX9 — AlphaFold Q9NQZ2 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (4)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    DHX9["<b>DHX9</b>"]
    Aging{"Aging"}
    DHX9 -->|"therapeutic target"| Aging
    Als{"Als"}
    DHX9 -->|"therapeutic target"| Als
    Neuroinflammation{"Neuroinflammation"}
    DHX9 -->|"therapeutic target"| Neuroinflammation
    Epilepsy{"Epilepsy"}
    DHX9 -->|"therapeutic target"| Epilepsy
    Autism{"Autism"}
    DHX9 -->|"therapeutic target"| Autism
    Ms{"Ms"}
    DHX9 -->|"therapeutic target"| Ms
    Inflammation{"Inflammation"}
    DHX9 -->|"therapeutic target"| Inflammation
    KCNT1["KCNT1"]
    DHX9 -->|"therapeutic target"| KCNT1
    KCNQ2["KCNQ2"]
    DHX9 -->|"therapeutic target"| KCNQ2
    GENES["GENES"]
    DHX9 -->|"associated with"| GENES
    SCN1A["SCN1A"]
    DHX9 -->|"therapeutic target"| SCN1A
    MTOR["MTOR"]
    DHX9 -->|"therapeutic target"| MTOR
    KCNQ2 -->|"therapeutic target"| DHX9
    KCNT1 -->|"therapeutic target"| DHX9
    GENES -->|"associated with"| DHX9
    EPILEPSY["EPILEPSY"]
    EPILEPSY -->|"therapeutic target"| DHX9
    style DHX9 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (17)

Target	Relation	Type	Str
Aging	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Neuroinflammation	therapeutic_target	disease	0.65
Epilepsy	therapeutic_target	disease	0.65
Autism	therapeutic_target	disease	0.65
Ms	therapeutic_target	disease	0.65
Inflammation	therapeutic_target	disease	0.65
KCNT1	therapeutic_target	gene	0.60
KCNQ2	therapeutic_target	gene	0.60
SCN1A	therapeutic_target	gene	0.60
MTOR	therapeutic_target	gene	0.60
RELN	associated_with	gene	0.60
GENES	associated_with	gene	0.60
Mtor	therapeutic_target	pathway	0.60
Epigenetic	therapeutic_target	pathway	0.60
Synaptic Plasticity	therapeutic_target	pathway	0.60
NEUROINFLAMMATION	therapeutic_target	gene	0.60

Incoming (4)

Source	Relation	Type	Str
KCNQ2	therapeutic_target	gene	0.60
KCNT1	therapeutic_target	gene	0.60
GENES	associated_with	gene	0.60
EPILEPSY	therapeutic_target	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found