Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about KCNT1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | KCNT1 |
| Full Name | Potassium Sodium-Activated Channel Subfamily T Member 1 / Slack |
| Aliases | KCNT1/Slack gene |
| Chromosome | 9q34.3 |
| Protein Type | Channel |
| Function | KCNT1/Slack channels have important neuronal functions |
| Primary Expression | the brain, particularly in the cortex, hippocampus, and thalamus<sup>[1]</sup> |
| UniProt ID | [Q7RTV0](https://www.uniprot.org/uniprot/Q7RTV0) |
| Ensembl ID | ENSG00000107140 |
| GeneCards | KCNT1 |
| Human Protein Atlas | KCNT1 |
| Potassium conductance | Provides outward K+ current activated by intracellular Na+, helping to repolarize neurons after action potentials<sup>[3]</sup> |
| Neuronal excitability | Regulates resting membrane potential and firing patterns, particularly in fast-firing neurons<sup>[4]</sup> |
| Sodium sensing | Activated by increases in intracellular sodium, serving as a sensor for metabolic stress<sup>[5]</sup> |
| Neuroprotection | May provide protection against sodium overload during ischemia or excitotoxicity<sup>[6]</sup> |
| Associated Diseases | neurodegeneration |
| KG Connections | 20 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
KCNT1["<b>KCNT1</b>"]
Aging{"Aging"}
KCNT1 -->|"therapeutic target"| Aging
Als{"Als"}
KCNT1 -->|"therapeutic target"| Als
Neuroinflammation{"Neuroinflammation"}
KCNT1 -->|"therapeutic target"| Neuroinflammation
Epilepsy{"Epilepsy"}
KCNT1 -->|"therapeutic target"| Epilepsy
Autism{"Autism"}
KCNT1 -->|"therapeutic target"| Autism
Ms{"Ms"}
KCNT1 -->|"therapeutic target"| Ms
Inflammation{"Inflammation"}
KCNT1 -->|"therapeutic target"| Inflammation
KCNQ2["KCNQ2"]
KCNT1 -->|"associated with"| KCNQ2
GENES["GENES"]
KCNT1 -->|"associated with"| GENES
SCN1A["SCN1A"]
KCNT1 -->|"therapeutic target"| SCN1A
MTOR["MTOR"]
KCNT1 -->|"therapeutic target"| MTOR
RELN["RELN"]
KCNT1 -->|"therapeutic target"| RELN
DHX9["DHX9"]
DHX9 -->|"therapeutic target"| KCNT1
KCNQ2 -->|"associated with"| KCNT1
style KCNT1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Aging | therapeutic_target | disease | 0.65 |
| Als | therapeutic_target | disease | 0.65 |
| Neuroinflammation | therapeutic_target | disease | 0.65 |
| Epilepsy | therapeutic_target | disease | 0.65 |
| Autism | therapeutic_target | disease | 0.65 |
| Ms | therapeutic_target | disease | 0.65 |
| Inflammation | therapeutic_target | disease | 0.65 |
| KCNQ2 | associated_with | gene | 0.60 |
| SCN1A | therapeutic_target | gene | 0.60 |
| MTOR | therapeutic_target | gene | 0.60 |
| RELN | therapeutic_target | gene | 0.60 |
| DHX9 | therapeutic_target | gene | 0.60 |
| GENES | associated_with | gene | 0.60 |
| Mtor | therapeutic_target | pathway | 0.60 |
| Epigenetic | therapeutic_target | pathway | 0.60 |
| Synaptic Plasticity | therapeutic_target | pathway | 0.60 |
| EPILEPSY | therapeutic_target | gene | 0.60 |
| NEUROINFLAMMATION | therapeutic_target | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||