Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about EGR4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Early Growth Response 4 - Activity-dependent transcription factor in synaptic plasticity and neurodegeneration
| Gene Symbol | EGR4 |
| Aliases | Early Growth Response 4 |
| Chromosome | 2p13.3 |
| Protein Type | Transcription Factor |
| Function | is a zinc finger transcription factor and member of the EGR (Early Growth Response) family of immediate-early genes. |
| Molecular Weight | 54 kDa |
| Amino Acids | 476 aa |
| Ensembl ID | ENSG00000186866 |
| GeneCards | EGR4 |
| Human Protein Atlas | EGR4 |
| Associated Diseases | Als, Cancer, Glioblastoma, Ms, Tumor |
| Interactions | BDNF, FOSB, Bdnf, MICROGLIA, Raf |
| KG Connections | 26 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
EGR4["<b>EGR4</b>"]
Cancer{"Cancer"}
EGR4 -->|"associated with"| Cancer
Tumor{"Tumor"}
EGR4 -->|"associated with"| Tumor
Als{"Als"}
EGR4 -->|"associated with"| Als
Ms{"Ms"}
EGR4 -->|"associated with"| Ms
Glioblastoma{"Glioblastoma"}
EGR4 -->|"associated with"| Glioblastoma
EGFR["EGFR"]
EGR4 -->|"associated with"| EGFR
CDKN2A["CDKN2A"]
EGR4 -->|"associated with"| CDKN2A
GBM["GBM"]
EGR4 -->|"associated with"| GBM
AND["AND"]
EGR4 -->|"expressed in"| AND
neurodegeneration["neurodegeneration"]
EGR4 -->|"implicated in"| neurodegeneration
PTEN["PTEN"]
PTEN -->|"associated with"| EGR4
CDKN2A -->|"associated with"| EGR4
GBM -->|"associated with"| EGR4
CANCER["CANCER"]
CANCER -->|"associated with"| EGR4
EGFR -->|"associated with"| EGR4
GLIOBLASTOMA["GLIOBLASTOMA"]
GLIOBLASTOMA -->|"associated with"| EGR4
style EGR4 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Cancer | associated_with | disease | 0.65 |
| Tumor | associated_with | disease | 0.65 |
| Als | associated_with | disease | 0.65 |
| Ms | associated_with | disease | 0.65 |
| Glioblastoma | associated_with | disease | 0.65 |
| Neurodegeneration | activates | disease | 0.65 |
| EGFR | associated_with | gene | 0.60 |
| CDKN2A | associated_with | gene | 0.60 |
| GBM | associated_with | gene | 0.60 |
| BDNF | activates | gene | 0.60 |
| FOSB | activates | gene | 0.60 |
| AND | expressed_in | gene | 0.60 |
| Microglia | activates | cell_type | 0.60 |
| Neuron | activates | cell_type | 0.60 |
| Bdnf | activates | protein | 0.60 |
| MICROGLIA | activates | gene | 0.60 |
| Raf | activates | protein | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||