gene

EGR4

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about EGR4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

26Connections
0Hypotheses
0Analyses
17Outgoing
9Incoming

Summary

Early Growth Response 4 - Activity-dependent transcription factor in synaptic plasticity and neurodegeneration

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🧬 Gene Info
Gene SymbolEGR4
AliasesEarly Growth Response 4
Chromosome2p13.3
Protein TypeTranscription Factor
Functionis a zinc finger transcription factor and member of the EGR (Early Growth Response) family of immediate-early genes.
Molecular Weight54 kDa
Amino Acids476 aa
Ensembl IDENSG00000186866
GeneCardsEGR4
Human Protein AtlasEGR4
Associated DiseasesAls, Cancer, Glioblastoma, Ms, Tumor
InteractionsBDNF, FOSB, Bdnf, MICROGLIA, Raf
KG Connections26 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Wiki Pages (3)

Knowledge base pages for this entity

Canonical Page

EGR4

gene · 1566 words

EGR3 Protein (Early Growth Response 3)

protein · 671 words

Genes

index · 271 words

Pathway Diagram

graph TD
    EGR4["<b>EGR4</b>"]
    Cancer{"Cancer"}
    EGR4 -->|"associated with"| Cancer
    Tumor{"Tumor"}
    EGR4 -->|"associated with"| Tumor
    Als{"Als"}
    EGR4 -->|"associated with"| Als
    Ms{"Ms"}
    EGR4 -->|"associated with"| Ms
    Glioblastoma{"Glioblastoma"}
    EGR4 -->|"associated with"| Glioblastoma
    EGFR["EGFR"]
    EGR4 -->|"associated with"| EGFR
    CDKN2A["CDKN2A"]
    EGR4 -->|"associated with"| CDKN2A
    GBM["GBM"]
    EGR4 -->|"associated with"| GBM
    AND["AND"]
    EGR4 -->|"expressed in"| AND
    neurodegeneration["neurodegeneration"]
    EGR4 -->|"implicated in"| neurodegeneration
    PTEN["PTEN"]
    PTEN -->|"associated with"| EGR4
    CDKN2A -->|"associated with"| EGR4
    GBM -->|"associated with"| EGR4
    CANCER["CANCER"]
    CANCER -->|"associated with"| EGR4
    EGFR -->|"associated with"| EGR4
    GLIOBLASTOMA["GLIOBLASTOMA"]
    GLIOBLASTOMA -->|"associated with"| EGR4
    style EGR4 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (17)

TargetRelationTypeStr
Cancerassociated_withdisease0.65
Tumorassociated_withdisease0.65
Alsassociated_withdisease0.65
Msassociated_withdisease0.65
Glioblastomaassociated_withdisease0.65

Incoming (9)

SourceRelationTypeStr
PTENassociated_withgene0.60
CDKN2Aassociated_withgene0.60
GBMassociated_withgene0.60
EGFRassociated_withgene0.60
FOSBactivatesgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found