Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about EIF4E: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | EIF4E |
| Function | Eif4E Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes. |
| Subcellular Localization | (via 4E-BP and transport proteins) **Neuronal Functions**: - Synaptic plasticit |
| Molecular Weight | 25 kDa |
| Amino Acids | 217 aa |
| Pathways | mtor |
| GeneCards | EIF4E |
| Human Protein Atlas | EIF4E |
| Associated Diseases | Glioma, Parkinson |
| Interactions | BCL-2, RIBOSOMAL PROTEIN S6, VEGF |
| KG Connections | 30 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
EIF4E["<b>EIF4E</b>"]
mRNA_Translation["mRNA Translation"]
EIF4E -->|"regulates"| mRNA_Translation
CYCS(["CYCS"])
EIF4E -->|"associated_with"| CYCS
Genes["Genes"]
EIF4E -->|"associated_with"| Genes
MTOR_SIGNALING["MTOR SIGNALING"]
EIF4E -->|"interacts_with"| MTOR_SIGNALING
MTORC1["MTORC1"]
EIF4E -->|"activates"| MTORC1
RAPAMYCIN["RAPAMYCIN"]
EIF4E -->|"activates"| RAPAMYCIN
MTOR(["MTOR"])
MTOR -->|"regulates"| EIF4E
MMP9(["MMP9"])
MMP9 -->|"associated_with"| EIF4E
GFAP(["GFAP"])
GFAP -->|"associated_with"| EIF4E
NCF1(["NCF1"])
NCF1 -->|"associated_with"| EIF4E
style EIF4E fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#4fc3f7| Target | Relation | Type | Str |
|---|---|---|---|
| mRNA Translation | regulates | process | 0.85 |
| Parkinson | associated_with | disease | 0.60 |
| CYCS | associated_with | gene | 0.50 |
| MTOR SIGNALING | interacts_with | concept | 0.50 |
| MTORC1 | activates | concept | 0.50 |
| RAPAMYCIN | activates | concept | 0.50 |
| BCL-2 | activates | protein | 0.50 |
| Glioma | activates | disease | 0.50 |
| SRPK1 | activates | concept | 0.50 |
| apoptosis | associated_with | process | 0.50 |
| Glioma | associated_with | disease | 0.50 |
| SRPK1 | associated_with | concept | 0.50 |
| NRAS | co_expressed_with | gene | 0.50 |
| PLCG1 | co_expressed_with | gene | 0.50 |
| GFAP | co_expressed_with | gene | 0.50 |
| MMP9 | co_expressed_with | gene | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| MTOR | regulates | protein | 0.70 |
| MMP9 | associated_with | gene | 0.50 |
| GFAP | associated_with | gene | 0.50 |
| NCF1 | associated_with | gene | 0.50 |
| CDC42 | associated_with | gene | 0.50 |
| SOD2 | associated_with | gene | 0.50 |
| mTOR | interacts_with | entity | 0.50 |
| RIBOSOMAL PROTEIN S6 | interacts_with | protein | 0.50 |
| VEGF | activates | gene | 0.50 |
| VEGF | associated_with | gene | 0.50 |
| CDKN2A | co_expressed_with | gene | 0.50 |
| CDKN2B | co_expressed_with | gene | 0.50 |
| CDC42 | co_expressed_with | gene | 0.50 |
| CYCS | co_expressed_with | gene | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||