gene

PLCG1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PLCG1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

28Connections

0Hypotheses

1Analyses

15Outgoing

13Incoming

0Experiments

3Debates

Summary

PLCG1 is a gene implicated in neurodegeneration research. Key relationships include: therapeutic target, activates, implicated in. Associated with Cancer, Glioblastoma, Ms. Connected to 12 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	PLCG1
Full Name	Phospholipase C Gamma 1
Aliases	Page for PLCG1
Protein Family	Phospholipase C gamma family
Protein Type	Enzyme
Function	PLCG1 is a phospholipase C isoform activated by receptor tyrosine kinases (RTKs).
Molecular Weight	148.5 kDa
Amino Acids	1290 aa
Pathways	oncogenic pathway activation
UniProt ID	P19174
GeneCards	PLCG1
Human Protein Atlas	PLCG1
X domain	Phosphorylase C-like phosphodiesterase core that catalyzes PIP2 hydrolysis
Y domain	Regulatory accessory domain required for catalytic activity
C2 domain	Calcium-dependent membrane targeting
Associated Diseases	neurodegeneration
Interactions	AUTOPHAGY, EGFR, LAMP2A, RB1, TP53
KG Connections	28 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: PLCG1 — AlphaFold P19174 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

PLCG1 - Phospholipase C Gamma 1

gene · 1817 words

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Pathway Diagram

graph TD
    PLCG1["PLCG1"]
    oncogenic_pathway_activation(["oncogenic pathway activation"])
    PLCG1 -->|"activates"| oncogenic_pathway_activation
    Glioblastoma{"Glioblastoma"}
    PLCG1 -->|"therapeutic target"| Glioblastoma
    Cancer{"Cancer"}
    PLCG1 -->|"therapeutic target"| Cancer
    Tumor{"Tumor"}
    PLCG1 -->|"activates"| Tumor
    Ms{"Ms"}
    PLCG1 -->|"therapeutic target"| Ms
    neurodegeneration["neurodegeneration"]
    PLCG1 -->|"implicated in"| neurodegeneration
    RB1["RB1"]
    RB1 -->|"activates"| PLCG1
    EGFR["EGFR"]
    EGFR -->|"activates"| PLCG1
    EP300["EP300"]
    EP300 -->|"therapeutic target"| PLCG1
    TP53["TP53"]
    TP53 -->|"activates"| PLCG1
    GBM["GBM"]
    GBM -->|"therapeutic target"| PLCG1
    CREBBP["CREBBP"]
    CREBBP -->|"therapeutic target"| PLCG1
    style PLCG1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (15)

Target	Relation	Type	Str
PLCG2	homologous_to	protein	0.90
Tumor	biomarker_for	disease	0.85
oncogenic pathway activation	activates	pathway	0.70
Glioblastoma	therapeutic_target	disease	0.65
Cancer	therapeutic_target	disease	0.65
Tumor	activates	disease	0.65
Ms	therapeutic_target	disease	0.65
Senescence	activates	disease	0.65
AUTOPHAGY	activates	gene	0.60
LAMP2A	activates	gene	0.60
TET2	associated_with	gene	0.60
TP53	associated_with	gene	0.60
U2AF1	associated_with	gene	0.60
TET2	co_expressed_with	gene	0.50
TP53	co_expressed_with	gene	0.50

Incoming (13)

Source	Relation	Type	Str
RB1	activates	gene	0.60
EGFR	activates	gene	0.60
EP300	therapeutic_target	gene	0.60
TP53	activates	gene	0.60
GBM	therapeutic_target	gene	0.60
CREBBP	therapeutic_target	gene	0.60
ATM	associated_with	gene	0.60
CDK6	associated_with	gene	0.60
CDKN2A	associated_with	gene	0.60
CDKN2B	associated_with	gene	0.60
NRAS	associated_with	gene	0.60
NRAS	co_expressed_with	gene	0.50
EIF4E	co_expressed_with	protein	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

TREM2 agonism vs antagonism in DAM microglia

neurodegeneration | 2026-04-01 | 6 hypotheses Top: 0.886

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (3)

Multi-agent debates referencing this entity

Related Research

Hypotheses and analyses mentioning PLCG1 in their description or question text

No additional research found