Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about SCN2B: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | SCN2B |
| Full Name | Sodium Voltage-Gated Channel Beta Subunit 2 |
| Aliases | Page for SCN2B Gene |
| Chromosome | 11q23.3 |
| Function | is a network-stability modifier rather than a single-cause disease gene. |
| Molecular Weight | 24 kDa |
| UniProt ID | O60939 |
| NCBI Gene ID | 6327 |
| Ensembl ID | ENSG00000177017 |
| OMIM | 601327 |
| GeneCards | SCN2B |
| Human Protein Atlas | SCN2B |
| Protein | SCN2B Protein |
| Associated Diseases | Inflammation |
| Interactions | SCN8A, GRM5, FGF13, CDK5R2, SLC17A7, STAT1 |
| KG Connections | 61 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
SCN2B["<b>SCN2B</b>"]
Inflammation["Inflammation"]
SCN2B -->|"associated with"| Inflammation
CDK5R2["CDK5R2"]
SCN2B -->|"therapeutic target"| CDK5R2
ISG15["ISG15"]
SCN2B -->|"therapeutic target"| ISG15
STAT1["STAT1"]
SCN2B -->|"associated with"| STAT1
GENES["GENES"]
SCN2B -->|"associated with"| GENES
ISG15["ISG15"]
SCN2B -->|"associated with"| ISG15
SCN8A["SCN8A"]
SCN2B -->|"associated with"| SCN8A
FGF13["FGF13"]
SCN2B -->|"associated with"| FGF13
INFLAMMATION["INFLAMMATION"]
SCN2B -->|"associated with"| INFLAMMATION
SLC17A7["SLC17A7"]
SCN2B -->|"associated with"| SLC17A7
AND["AND"]
SCN2B -->|"associated with"| AND
CDK5R2["CDK5R2"]
SCN2B -->|"associated with"| CDK5R2
HUB_GENES["HUB GENES"]
SCN2B -->|"associated with"| HUB_GENES
GRM5["GRM5"]
SCN2B -->|"associated with"| GRM5
SLC17A7["SLC17A7"]
SLC17A7 -->|"therapeutic target"| SCN2B
GRM5["GRM5"]
GRM5 -->|"therapeutic target"| SCN2B
SCN8A["SCN8A"]
SCN8A -->|"therapeutic target"| SCN2B
STAT1["STAT1"]
STAT1 -->|"therapeutic target"| SCN2B
FGF13["FGF13"]
FGF13 -->|"therapeutic target"| SCN2B
SCN8A["SCN8A"]
SCN2B -->|"interacts with"| SCN8A
GRM5["GRM5"]
SCN2B -->|"interacts with"| GRM5
FGF13["FGF13"]
SCN2B -->|"interacts with"| FGF13
CDK5R2["CDK5R2"]
SCN2B -->|"interacts with"| CDK5R2
SLC17A7["SLC17A7"]
SCN2B -->|"interacts with"| SLC17A7
Genes["Genes"]
SCN2B -->|"interacts with"| Genes
inflammation["inflammation"]
SCN2B -->|"interacts with"| inflammation
ISG15["ISG15"]
ISG15 -->|"interacts with"| SCN2B
STAT1["STAT1"]
STAT1 -->|"interacts with"| SCN2B
ISG15["ISG15"]
ISG15 -->|"associated with"| SCN2B
STAT1["STAT1"]
STAT1 -->|"associated with"| SCN2B| Target | Relation | Type | Str |
|---|---|---|---|
| Encephalitis | therapeutic_target | disease | 0.65 |
| Inflammation | associated_with | disease | 0.65 |
| CDK5R2 | therapeutic_target | gene | 0.60 |
| ISG15 | therapeutic_target | gene | 0.60 |
| STAT1 | associated_with | gene | 0.60 |
| ISG15 | associated_with | gene | 0.60 |
| SCN8A | associated_with | gene | 0.60 |
| FGF13 | associated_with | gene | 0.60 |
| SLC17A7 | associated_with | gene | 0.60 |
| CDK5R2 | associated_with | gene | 0.60 |
| GRM5 | associated_with | gene | 0.60 |
| STAT1 | therapeutic_target | gene | 0.60 |
| SCN8A | therapeutic_target | gene | 0.60 |
| GRM5 | therapeutic_target | gene | 0.60 |
| SLC17A7 | therapeutic_target | gene | 0.60 |
| FGF13 | therapeutic_target | gene | 0.60 |
| Cdk5 | therapeutic_target | protein | 0.60 |
| STAT1 | interacts_with | gene | 0.60 |
| SCN8A | targets | gene | 0.60 |
| SLC17A7 | targets | gene | 0.60 |
| STAT1 | targets | gene | 0.60 |
| TREH | associated_with | gene | 0.60 |
| XPO1 | associated_with | gene | 0.60 |
| GENES | associated_with | gene | 0.60 |
| INFLAMMATION | associated_with | gene | 0.60 |
| AND | associated_with | gene | 0.60 |
| HUB GENES | associated_with | gene | 0.60 |
| Interferon | therapeutic_target | protein | 0.60 |
| Interferon Signaling | therapeutic_target | pathway | 0.60 |
| App | therapeutic_target | protein | 0.60 |
| Fgf | therapeutic_target | protein | 0.60 |
| SCN8A | interacts_with | gene | 0.50 |
| GRM5 | interacts_with | gene | 0.50 |
| FGF13 | interacts_with | gene | 0.50 |
| CDK5R2 | interacts_with | protein | 0.50 |
| SLC17A7 | interacts_with | protein | 0.50 |
| inflammation | interacts_with | pathway | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| SLC17A7 | therapeutic_target | gene | 0.60 |
| GRM5 | therapeutic_target | gene | 0.60 |
| SCN8A | therapeutic_target | gene | 0.60 |
| STAT1 | therapeutic_target | gene | 0.60 |
| FGF13 | therapeutic_target | gene | 0.60 |
| ISG15 | therapeutic_target | gene | 0.60 |
| CDK5R2 | therapeutic_target | gene | 0.60 |
| CDK5R2 | interacts_with | gene | 0.60 |
| FGF13 | interacts_with | gene | 0.60 |
| GRM5 | interacts_with | gene | 0.60 |
| CDK5R2 | targets | gene | 0.60 |
| FGF13 | targets | gene | 0.60 |
| GRM5 | targets | gene | 0.60 |
| ISG15 | targets | gene | 0.60 |
| CDK5R2 | associated_with | gene | 0.60 |
| FGF13 | associated_with | gene | 0.60 |
| GRM5 | associated_with | gene | 0.60 |
| DDX3X | associated_with | gene | 0.60 |
| KMT2A | associated_with | gene | 0.60 |
| PICALM | associated_with | gene | 0.60 |
| ISG15 | interacts_with | gene | 0.50 |
| STAT1 | interacts_with | gene | 0.50 |
| ISG15 | associated_with | gene | 0.50 |
| STAT1 | associated_with | gene | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||