protein

cdk5

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about cdk5: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

627Connections

0Hypotheses

1Analyses

50Outgoing

50Incoming

Summary

Cyclin-Dependent Kinase 5 (CDK5) is a proline-directed serine/threonine kinase essential for neuronal migration, axon guidance, and synaptic plasticity during brain development. Unlike other CDKs, CDK5 is activated by p35 and p39 (not cyclins) and is primarily active in post-mitotic neurons. Under neurotoxic stress, calpain cleaves p35 to p25, causing aberrant CDK5 hyperactivation that drives tau hyperphosphorylation, amyloid-beta production, and neuronal apoptosis. CDK5/p25 is implicated in AD, PD, ALS, and stroke. CDK5 phosphorylates tau at multiple AD-relevant epitopes. Selective inhibition of CDK5/p25 (without blocking CDK5/p35) is an active therapeutic strategy for neurodegeneration.

View on Wiki →

🔬 Protein Info

Gene Symbol	CDK5
Protein Family	CMGC kinase group, CDK family
Protein Type	Serine/Threonine Kinase
Function	Cdk5 knockout mice die at birth with severe cortical layering defects due to failed neuronal migration.
Primary Expression	Cytoplasm, nucleus, synapses, growth cones, perinuclear region
Amino Acids	291 aa
Pathways	Apoptosis, Autophagy, Checkpoint Inhibitor, Immune Checkpoint, Immune Response
GeneCards	CDK5
Human Protein Atlas	CDK5
Associated Diseases	ALS, Aging, Als, Alzheimer, Ataxia, Inflammation
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    CDK5["CDK5"]
    CDK5 -->|"inhibits"| BECN1["BECN1"]
    CDK5 -->|"interacts"| Ms["Ms"]
    CDK5 -->|"activates"| Als["Als"]
    CDK5 -->|"target for"| Alzheimer["Alzheimer"]
    CDK5 -->|"inhibits"| Neurodegeneration["Neurodegeneration"]
    CDK5 -->|"interacts"| Parkinson["Parkinson"]
    DCX["DCX"] -->|"interacts"| CDK5
    PAFAH1B1["PAFAH1B1"] -->|"interacts"| CDK5
    DAB1["DAB1"] -->|"interacts"| CDK5
    LIS1["LIS1"] -->|"interacts"| CDK5
    BACE1["BACE1"] -->|"inhibits"| CDK5
    PHAGOCYTOSIS["PHAGOCYTOSIS"] -->|"inhibits"| CDK5
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] -->|"inhibits"| CDK5
    CDK1["CDK1"] -->|"activates"| CDK5
    TAU_TANGLES["TAU TANGLES"] -->|"inhibits"| CDK5
    APP["APP"] -->|"inhibits"| CDK5

Outgoing (428)

Target	Relation	Type	Str
ds-83b31ef18d49	provides_data_for	dataset	1.00
Tau aggregation	mediates	process	0.90
NEURONAL MIGRATION	regulates	entity	0.85
Hyperthyroidism	associated_with	disease	0.85
Alzheimer's disease	involved_in	disease	0.85
cell cycle	regulates	biological_process	0.80
p25	activates	protein	0.80
mitochondrial_division	induces	biological_process	0.80
Neurodegeneration	involved_in	disease	0.80
Nucleokinesis	involved_in	process	0.75
Als	activates	disease	0.75
Alzheimer	therapeutic_target	disease	0.75
Als	expressed_in	disease	0.75
PARKINSON'S DISEASE	associated_with	disease	0.75
BECN1	inhibits	protein	0.70
Wnt signaling	participates_in	pathway	0.70
NEURODEGENERATION	destabilizes	phenotype	0.70
GSK3	activates	gene	0.70
GSK3	implicated_in	gene	0.70
TAU	associated_with	gene	0.65
VCP	associated_with	gene	0.65
PINK1	phosphorylates	gene	0.65
PINK1	interacts_with	gene	0.65
TAU	causes	protein	0.65
DRP1	causes	gene	0.65
NTRK2	co_discussed	gene	0.65
tau	co_discussed	concept	0.65
neuron	co_discussed	concept	0.65
LRRK2	co_discussed	gene	0.65
PINK1	co_discussed	gene	0.65
neuroinflammation	co_discussed	concept	0.65
SOD1	co_discussed	gene	0.65
tau	mediates	concept	0.65
autophagy	co_discussed	concept	0.65
amyloid	co_discussed	concept	0.65
TAU	regulates	protein	0.65
BDNF	degrades	gene	0.65
TAU	produces	protein	0.65
Ms	interacts_with	disease	0.65
Neurodegeneration	inhibits	disease	0.65
Ms	activates	disease	0.65
Alzheimer	activates	disease	0.65
NEURODEGENERATION	associated_with	concept	0.65
Alzheimer	inhibits	disease	0.65
Ms	inhibits	disease	0.65
Parkinson	interacts_with	disease	0.65
Alzheimer	interacts_with	disease	0.65
Neurodegeneration	interacts_with	disease	0.65
Schizophrenia	expressed_in	disease	0.65
ALS	causes	disease	0.65

Incoming (199)

Source	Relation	Type	Str
ds-83b31ef18d49	data_in	dataset	1.00
Protopanaxatriol	inhibits	compound	0.90
Hyperthyroidism	upregulates	disease	0.85
E2F1	regulates	gene	0.80
ABETA	activates	protein	0.80
RESVERATROL	modulates	drug	0.75
TAU	activates	protein	0.70
TAU	destabilizes	protein	0.70
TAU	associated_with	gene	0.66
AKT	expressed_in	gene	0.65
BACE1	expressed_in	gene	0.65
BDNF	co_discussed	gene	0.65
SOD1	treats	gene	0.65
AMPK	activates	gene	0.65
AMPK	regulates	gene	0.65
AMPK	phosphorylates	gene	0.65
AMPK	causes	gene	0.65
METFORMIN	inhibits	drug	0.65
GABA	interacts_with	phenotype	0.65
NEURONS	inhibits	cell_type	0.65
NEURONS	regulates	cell_type	0.65
CALCIUM SIGNALING	regulates	pathway	0.65
N-ACETYLCYSTEINE	treats	drug	0.65
N-ACETYLCYSTEINE	activates	drug	0.65
OXIDATIVE STRESS	activates	phenotype	0.65
APOPTOSIS	treats	phenotype	0.65
N-ACETYLCYSTEINE	inhibits	drug	0.65
NEURONS	causes	cell_type	0.65
ALZHEIMER'S DISEASE	associated_with	disease	0.64
DCX	interacts_with	gene	0.60
PAFAH1B1	interacts_with	gene	0.60
DAB1	interacts_with	gene	0.60
LIS1	interacts_with	gene	0.60
BACE1	inhibits	gene	0.60
CDK1	activates	gene	0.60
APP	inhibits	gene	0.60
TAU	inhibits	gene	0.60
PSEN1	interacts_with	gene	0.60
PRKN	interacts_with	gene	0.60
SORL1	interacts_with	gene	0.60
BACE1	interacts_with	gene	0.60
TAU	interacts_with	gene	0.60
SNCA	interacts_with	gene	0.60
SNCAIP	interacts_with	gene	0.60
GSK3B	interacts_with	gene	0.60
GSN	regulates	gene	0.60
SNAP25	expressed_in	gene	0.60
PPP1R1B	regulates	gene	0.60
SNAP29	expressed_in	gene	0.60
REELIN	causes	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

What evidence supports Cdk5 activation as THE primary cause of AD versus other e

neurodegeneration | 2026-04-10 | 0 hypotheses

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

cdk5

Understanding Entity Pages

Summary

Wiki Pages (20)

cbs-psp-daily-action-plan

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

Progressive Supranuclear Palsy (PSP)

Corticobasal Syndrome (CBS)

Novel Therapy Index

CBS/PSP Supplements Guide

Myoclonus and Cortical Hyperexcitability in Corticobasal Syndrome

nimodipine-als

Therapeutics

Frontotemporal Dementia (FTD) Mechanistic Pathway

CBS/PSP Clinical Trials Guide

Axonal Transport Dysfunction Comparison Across Neurodegenerative Diseases

Melatonin for Tauopathy: Comprehensive Evidence Synthesis

Vascular Cognitive Impairment (VCI)

deferiprone-neurodegeneration

Infectious Triggers in Alzheimer's Disease

Epigenetic Alterations in Alzheimer's Disease

Traumatic Brain Injury and Neurodegeneration Pathway

Excitotoxicity in Neurodegeneration