gene

FHL1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about FHL1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

35Connections

0Hypotheses

0Analyses

22Outgoing

13Incoming

Summary

Page for FHL1 Gene

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🧬 Gene Info

Gene Symbol	FHL1
Full Name	Four and a Half LIM Domains 1
Chromosome	Xq26.3
Function	FHL1 encodes a member of the four-and-a-half LIM domain protein family.
Primary Expression	skeletal muscle, heart, and brain, particularly in motor neurons of the spinal cord and cortical neurons
Molecular Weight	32 kDa
Amino Acids	55 aa
Pathways	Camp Signaling
UniProt ID	[Q13642](https://www.uniprot.org/uniprot/Q13642)
Ensembl ID	ENSG00000022267
OMIM	300163
GeneCards	FHL1
Human Protein Atlas	FHL1
Associated Diseases	neurodegeneration
KG Connections	35 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (7)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    FHL1["<b>FHL1</b>"]
    Carcinoma{"Carcinoma"}
    FHL1 -->|"regulates"| Carcinoma
    EGFR(["EGFR"])
    FHL1 -->|"regulates"| EGFR
    GENES(["GENES"])
    FHL1 -->|"co_discussed"| GENES
    GRIA3(["GRIA3"])
    FHL1 -->|"regulates"| GRIA3
    MAPT(["MAPT"])
    FHL1 -->|"co_discussed"| MAPT
    PDE4D(["PDE4D"])
    FHL1 -->|"regulates"| PDE4D
    DDB1(["DDB1"])
    DDB1 -->|"regulates"| FHL1
    AND(["AND"])
    AND -->|"regulates"| FHL1
    RGS2(["RGS2"])
    RGS2 -->|"regulates"| FHL1
    DNA(["DNA"])
    DNA -->|"associated_with"| FHL1
    style FHL1 fill:#1a3a4a,stroke:#ce93d8,stroke-width:3px,color:#ce93d8

Outgoing (22)

Target	Relation	Type	Str
Carcinoma	regulates	disease	0.65
Alzheimer	regulates	disease	0.65
Dementia	regulates	disease	0.65
Aging	regulates	disease	0.65
Neurodegeneration	regulates	disease	0.65
ACTN2	regulates	gene	0.60
CLU	regulates	gene	0.60
MAPT	regulates	gene	0.60
Rb	regulates	protein	0.60
ALZHEIMER	regulates	gene	0.60
DEMENTIA	regulates	gene	0.60
AGING	regulates	gene	0.60
AND	regulates	gene	0.60
ALZHEIMER'S DISEASE	regulates	gene	0.60
Camp Signaling	regulates	pathway	0.60
Egfr	regulates	protein	0.60
App	regulates	protein	0.60
EGFR	regulates	gene	0.50
GRIA3	regulates	gene	0.50
MAPT	co_discussed	gene	0.50
PDE4D	regulates	gene	0.50
GENES	co_discussed	gene	0.50

Incoming (13)

Source	Relation	Type	Str
DDB1	regulates	gene	0.60
RGS2	regulates	gene	0.60
ACTN2	regulates	gene	0.60
CLU	regulates	gene	0.60
PDE4D	regulates	gene	0.60
EGFR	regulates	gene	0.60
AND	regulates	gene	0.60
DNA	associated_with	gene	0.60
AGING	regulates	gene	0.60
NEURODEGENERATION	regulates	gene	0.60
ALZHEIMER	regulates	gene	0.50
DEMENTIA	regulates	gene	0.50
actn2	regulates	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

FHL1

Understanding Entity Pages

Summary

Wiki Pages (7)

FHL1 Gene

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FHL1 Protein

ACTN2 — Actinin Alpha 2

RGS2 Gene - Regulator of G Protein Signaling 2