gene

PDE4D

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PDE4D: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

55Connections

0Hypotheses

0Analyses

35Outgoing

20Incoming

0Experiments

Summary

PDE4D (Phosphodiesterase 4D) - cAMP-specific phosphodiesterase critical for synaptic plasticity, learning, memory, and implicated in neurodegenerative diseases

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🧬 Gene Info

Gene Symbol	PDE4D
Full Name	Phosphodiesterase 4D (cAMP-specific)
Aliases	Phosphodiesterase 4D
Chromosome	5q12.1
Function	is a member of the phosphodiesterase 4 (PDE4) family that specifically hydrolyzes cyclic adenosine monophosphate (cAMP), serving as a key regulator of cAMP signaling in cells.
Primary Expression	Brain (cortex, hippocampus, cerebellum), immune cells, smooth muscle
Subcellular Localization	Isoform expression varies by brain region and cell type
Amino Acids	886 aa
Pathways	Camp Signaling
UniProt ID	Q08499
NCBI Gene ID	5145
Ensembl ID	ENSG00000100162
OMIM	600129
GeneCards	PDE4D
Human Protein Atlas	PDE4D
Associated Diseases	neurodegeneration
Interactions	SIRT1, PDE4B, PARKIN, CREB1, PER, GENES
KG Connections	55 knowledge graph edges
Databases	GeneCards HPA STRING

Wiki Pages (14)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    PDE4D["PDE4D"]
    CREB["CREB"]
    CREB1["CREB1"]
    PINK1["PINK1"]
    PARKIN["PARKIN"]
    SIRT1["SIRT1"]
    PDE4B["PDE4B"]
    OxStress["Oxidative Stress"]
    Mitophagy["Mitophagy"]
    MitoFunc["Mitochondrial Function"]
    MitoDysf["Mitochondrial Dysfunction"]
    Neurodegeneration["Neurodegeneration"]
    HeartFailure["Heart Failure"]
    Cancer["Cancer"]

    CREB -->|"activates"| PDE4D
    PINK1 -->|"activates"| PDE4D
    OxStress -->|"activates"| PDE4D
    
    PDE4D -->|"activates"| SIRT1
    PDE4D -->|"activates"| PDE4B
    PDE4D -->|"activates"| PARKIN
    PDE4D -->|"activates"| OxStress
    PDE4D -->|"inhibits"| CREB1
    PDE4D -->|"inhibits"| Mitophagy
    PDE4D -->|"inhibits"| MitoDysf
    PDE4D -->|"therapeutic_target"| MitoFunc
    PDE4D -->|"implicated_in"| Neurodegeneration
    PDE4D -->|"inhibits"| HeartFailure
    PDE4D -->|"therapeutic_target"| Cancer
    
    Mitophagy -->|"inhibits"| PDE4D

    style PDE4D fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px
    style SIRT1 fill:#1b5e20
    style PARKIN fill:#1b5e20
    style MitoFunc fill:#1b5e20
    style CREB fill:#4a1a6b
    style CREB1 fill:#4a1a6b
    style PINK1 fill:#4a1a6b
    style PDE4B fill:#4a1a6b
    style OxStress fill:#ef5350
    style MitoDysf fill:#ef5350
    style Neurodegeneration fill:#7d4200
    style HeartFailure fill:#7d4200
    style Cancer fill:#7d4200
    style Mitophagy fill:#1b5e20

Outgoing (35)

Target	Relation	Type	Str
PINK1/Parkin-mediated mitophagy	inhibits	process	0.95
cAMP-PKA-CREB-SIRT1 signaling pathway	inhibits	pathway	0.93
Heart Failure	inhibits	disease	0.65
Cardiac	inhibits	disease	0.65
Cachexia	therapeutic_target	disease	0.65
Cancer	therapeutic_target	disease	0.65
Alzheimer	regulates	disease	0.65
Dementia	regulates	disease	0.65
Aging	regulates	disease	0.65
Neurodegeneration	regulates	disease	0.65
SIRT1	activates	gene	0.60
PDE4B	activates	gene	0.60
PARKIN	activates	gene	0.60
CREB1	inhibits	gene	0.60
MAPT	regulates	gene	0.60
EGFR	regulates	gene	0.60
GRIA3	regulates	gene	0.60
FHL1	regulates	gene	0.60
ACTN2	regulates	gene	0.60
CLU	regulates	gene	0.60
Rb	regulates	protein	0.60
PER	inhibits	gene	0.60
Oxidative Stress	activates	pathway	0.60
Mitophagy	inhibits	pathway	0.60
CANCER	therapeutic_target	gene	0.60
GENES	inhibits	gene	0.60
MITOCHONDRIAL DYSFUNCTION	inhibits	gene	0.60
Mitochondrial Function	therapeutic_target	pathway	0.60
DEMENTIA	regulates	gene	0.60
AGING	regulates	gene	0.60
Camp Signaling	regulates	pathway	0.60
ALZHEIMER	regulates	gene	0.60
Egfr	regulates	protein	0.60
App	regulates	protein	0.60
oxidative stress response	participates_in	pathway	0.60

Incoming (20)

Source	Relation	Type	Str
PINK1	activates	gene	0.60
ACTN2	regulates	gene	0.60
CLU	regulates	gene	0.60
EGFR	regulates	gene	0.60
GRIA3	regulates	gene	0.60
HCN1	expressed_in	gene	0.60
HCN1	regulates	gene	0.60
CREB	activates	gene	0.60
MITOPHAGY	inhibits	gene	0.60
OXIDATIVE STRESS	activates	gene	0.60
AGING	regulates	gene	0.60
NEURODEGENERATION	regulates	gene	0.60
AND	regulates	gene	0.60
ALZHEIMER'S DISEASE	regulates	gene	0.60
FHL1	regulates	gene	0.50
MAPT	regulates	gene	0.50
ALZHEIMER	regulates	gene	0.50
DEMENTIA	regulates	gene	0.50
GENES	co_discussed	gene	0.50
actn2	regulates	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

PDE4D

Understanding Entity Pages

Summary

Wiki Pages (14)

PDE4D Gene

Leukoaraiosis in Neurodegeneration

Ibudilast

cAMP Signaling in Neurodegeneration

PDE4 Inhibitor PD Trial

PDE4B — Phosphodiesterase 4B

DISC1 — Disrupted in Schizophrenia 1

PDE4C — Phosphodiesterase 4C

PDE4D Protein — Phosphodiesterase 4D

ACTN2 — Actinin Alpha 2

GRIA3 Protein

PDE4C Protein — Phosphodiesterase 4C

Proteins