gene

DDB1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about DDB1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

107Connections

0Hypotheses

0Analyses

50Outgoing

28Incoming

No summary available yet. View on Wiki →

🧬 Gene Info

Gene Symbol	DDB1
Full Name	DNA Damage Binding Protein 1
Aliases	UV-DDB1, XPE-BF
Chromosome	11q12.2
Function	DNA damage recognition and repair, E3 ubiquitin ligase adapter
Molecular Weight	126.9 kDa
Amino Acids	1140
Exons	22
Pathways	Nucleotide excision repair, CUL4-DDB1 ubiquitin ligase
UniProt ID	Q16531
Ensembl ID	ENSG00000167986
GeneCards	DDB1
Human Protein Atlas	DDB1
CUL4A/CUL4B	Scaffold proteins that recruit the E2 conjugating enzyme
ROC1	RING finger protein that activates E2 enzymes
Associated Diseases	Cancer, Lung Cancer
Known Drugs/Compounds	rapamycin
Interactions	UBIQUITIN, WIPI2, AMBRA1, GAPDH, GLB1, MAP1LC3B
KG Connections	107 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: DDB1 — AlphaFold Q16531 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (13)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    DDB1["DDB1"] -->|"component of"| CRL4["CRL4"]
    style CRL4 fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    DDB1["DDB1"] -->|"binds"| GSPT1["GSPT1"]
    style GSPT1 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    DDB1["DDB1"] -->|"binds"| PHGDH["PHGDH"]
    style PHGDH fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    DDB1["DDB1"] -->|"regulates"| Als["Als"]
    style Als fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#e0e0e0
    DDB1["DDB1"] -->|"activates"| UBIQUITIN["UBIQUITIN"]
    style UBIQUITIN fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    DDB1["DDB1"] -->|"regulates"| Cancer["Cancer"]
    style Cancer fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#e0e0e0
    DDB1["DDB1"] -->|"regulates"| Ms["Ms"]
    style Ms fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#e0e0e0
    SOX2["SOX2"] -->|"interacts"| DDB1["DDB1"]
    style SOX2 fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
    TAZ["TAZ"] -->|"regulates"| DDB1["DDB1"]
    style TAZ fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    LATS1["LATS1"] -->|"regulates"| DDB1["DDB1"]
    style LATS1 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    YAP["YAP"] -->|"regulates"| DDB1["DDB1"]
    style YAP fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    TSC2["TSC2"] -->|"regulates"| DDB1["DDB1"]
    style TSC2 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#e0e0e0
    style DDB1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (79)

Target	Relation	Type	Str
CRL4	component_of	entity	0.90
GSPT1	binds	gene	0.90
PHGDH	binds	gene	0.80
Als	regulates	disease	0.75
UBIQUITIN	activates	gene	0.70
Cancer	regulates	disease	0.65
Ms	regulates	disease	0.65
Leukemia	regulates	disease	0.65
Als	interacts_with	disease	0.65
Ms	interacts_with	disease	0.65
Tumor	interacts_with	disease	0.65
Tumor	therapeutic_target	disease	0.65
Cancer	associated_with	disease	0.65
Als	therapeutic_target	disease	0.65
Carcinoma	therapeutic_target	disease	0.65
Lung Cancer	associated_with	disease	0.65
Tumor	regulates	disease	0.65
Carcinoma	regulates	disease	0.65
Aging	activates	disease	0.65
LATS1	regulates	gene	0.60
TAZ	regulates	gene	0.60
FAS	therapeutic_target	gene	0.60
UBIQUITIN	associated_with	gene	0.60
WIPI2	activates	gene	0.60
Mitosis	activates	pathway	0.60
TSC2	regulates	gene	0.60
ATF4	regulates	gene	0.60
TSC1	regulates	gene	0.60
UBIQUITIN	interacts_with	gene	0.60
MTOR	regulates	gene	0.60
AMBRA1	interacts_with	gene	0.60
AMBRA1	regulates	gene	0.60
RGS2	regulates	gene	0.60
FHL1	regulates	gene	0.60
GAPDH	activates	gene	0.60
GLB1	activates	gene	0.60
MAP1LC3B	activates	gene	0.60
MTOR	activates	gene	0.60
STK11	activates	gene	0.60
TSC2	activates	gene	0.60
ferroptosis	participates_in	pathway	0.60
Mtor	regulates	pathway	0.60
Apoptosis	regulates	pathway	0.60
DNA	activates	gene	0.60
Autophagy	activates	pathway	0.60
YAP	regulates	gene	0.60
Hippo Pathway	regulates	pathway	0.60
Autophagy	interacts_with	pathway	0.60
CANCER	regulates	gene	0.60
P53	therapeutic_target	gene	0.60

Incoming (28)

Source	Relation	Type	Str
TAZ	regulates	gene	0.60
LATS1	regulates	gene	0.60
TSC2	regulates	gene	0.60
ATF4	regulates	gene	0.60
TSC1	regulates	gene	0.60
MTOR	regulates	gene	0.60
WIPI2	activates	gene	0.60
UBIQUITIN	interacts_with	gene	0.60
UBIQUITIN	activates	gene	0.60
AMBRA1	interacts_with	gene	0.60
BAX	therapeutic_target	gene	0.60
EEF2	activates	gene	0.60
ANG	inhibits	gene	0.60
ACTB	activates	gene	0.60
AURKB	activates	gene	0.60
CDK1	activates	gene	0.60
YAP	regulates	gene	0.60
ATG	regulates	gene	0.60
APOPTOSIS	regulates	gene	0.60
AUTOPHAGY	activates	gene	0.60
AUTOPHAGY	interacts_with	gene	0.60
CANCER	regulates	gene	0.60
HIPPO	regulates	gene	0.60
DNA	interacts_with	gene	0.60
RNA	activates	gene	0.60
AMPK	activates	gene	0.60
ATG	activates	gene	0.60
rapamycin	targets	drug	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

DDB1

Understanding Entity Pages

Wiki Pages (13)

DDB1 — DNA Damage Binding Protein 1

DLK2 — Delta-Like Non-Canonical Notch Ligand 2

DDB2 Gene

Cockayne Syndrome

DCAF17 Gene - DDB1 and CUL4 Associated Factor 17

FOXO3 Protein (Forkhead Box O3)

ERCC8

ERCC9 (FANCN) - DNA Repair and Neurodegeneration

CUL4A Gene (Cullin 4A)

FHL1 Gene

Woodhouse-Sakati Syndrome (WSS)