Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about RGS2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | RGS2 |
| Full Name | Regulator of G Protein Signaling 2 |
| Aliases | Page for RGS2 Gene, Page for RGS2 Protein |
| Chromosome | 1q31.3 |
| Function | RGS2 is a key negative regulator of G protein signaling |
| Primary Expression | many tissues: |
| Molecular Weight | 24 kDa |
| UniProt ID | P41221 |
| NCBI Gene ID | 5997 |
| Ensembl ID | ENSG00000147251 |
| OMIM | 600861 |
| GeneCards | RGS2 |
| Human Protein Atlas | RGS2 |
| Associated Diseases | neurodegeneration |
| Interactions | CDC42, RAB5, ARHGEF7, AUTOPHAGY, RAB7L1, RAC1 |
| KG Connections | 27 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
RGS2["<b>RGS2</b>"]
Parkinson{"Parkinson"}
RGS2 -->|"interacts with"| Parkinson
Ms{"Ms"}
RGS2 -->|"interacts with"| Ms
CDC42["CDC42"]
RGS2 -->|"interacts with"| CDC42
RAB5["RAB5"]
RGS2 -->|"interacts with"| RAB5
Autophagy(["Autophagy"])
RGS2 -->|"interacts with"| Autophagy
Mapk(["Mapk"])
RGS2 -->|"interacts with"| Mapk
neurodegeneration["neurodegeneration"]
RGS2 -->|"implicated in"| neurodegeneration
PARKINSON_S_DISEASE["PARKINSON'S DISEASE"]
PARKINSON_S_DISEASE -->|"interacts with"| RGS2
RAB7L1["RAB7L1"]
RAB7L1 -->|"interacts with"| RGS2
ARHGEF7["ARHGEF7"]
ARHGEF7 -->|"interacts with"| RGS2
RAC1["RAC1"]
RAC1 -->|"interacts with"| RGS2
LRRK2["LRRK2"]
LRRK2 -->|"interacts with"| RGS2
AUTOPHAGY["AUTOPHAGY"]
AUTOPHAGY -->|"interacts with"| RGS2
style RGS2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Parkinson | interacts_with | disease | 0.65 |
| Ms | interacts_with | disease | 0.65 |
| Carcinoma | regulates | disease | 0.65 |
| CDC42 | interacts_with | gene | 0.60 |
| RAB5 | interacts_with | gene | 0.60 |
| ARHGEF7 | interacts_with | gene | 0.60 |
| FHL1 | regulates | gene | 0.60 |
| Autophagy | interacts_with | pathway | 0.60 |
| Mapk | interacts_with | pathway | 0.60 |
| AUTOPHAGY | interacts_with | gene | 0.60 |
| DNA | associated_with | gene | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| RAB7L1 | interacts_with | gene | 0.60 |
| ARHGEF7 | interacts_with | gene | 0.60 |
| RAC1 | interacts_with | gene | 0.60 |
| LRRK2 | interacts_with | gene | 0.60 |
| CDC42 | interacts_with | gene | 0.60 |
| DDB1 | regulates | gene | 0.60 |
| CD163 | expressed_in | gene | 0.60 |
| LAMP2 | expressed_in | gene | 0.60 |
| PICALM | expressed_in | gene | 0.60 |
| PIN1 | expressed_in | gene | 0.60 |
| PARKINSON'S DISEASE | interacts_with | gene | 0.60 |
| AUTOPHAGY | interacts_with | gene | 0.60 |
| AND | interacts_with | gene | 0.60 |
| PARKINSON | interacts_with | gene | 0.60 |
| MAPK | interacts_with | gene | 0.60 |
| AND | regulates | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||