gene

RGS2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RGS2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

27Connections
0Hypotheses
0Analyses
11Outgoing
16Incoming

Summary

Page for RGS2 Gene - Regulator of G Protein Signaling 2

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🧬 Gene Info
Gene SymbolRGS2
Full NameRegulator of G Protein Signaling 2
AliasesPage for RGS2 Gene, Page for RGS2 Protein
Chromosome1q31.3
FunctionRGS2 is a key negative regulator of G protein signaling
Primary Expressionmany tissues:
Molecular Weight24 kDa
UniProt IDP41221
NCBI Gene ID5997
Ensembl IDENSG00000147251
OMIM600861
GeneCardsRGS2
Human Protein AtlasRGS2
Associated Diseasesneurodegeneration
InteractionsCDC42, RAB5, ARHGEF7, AUTOPHAGY, RAB7L1, RAC1
KG Connections27 knowledge graph edges
DatabasesGeneCardsHPASTRING
🔮 Predicted Structure: RGS2 — AlphaFold P41221 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (7)

Knowledge base pages for this entity

Canonical Page

RGS2 Gene - Regulator of G Protein Signaling 2

gene · 578 words

G Protein-Activated Inward Rectifier Potassium Channel 1 (GIRK1/KCNJ3)

protein · 1418 words

RGS2 Protein - Regulator of G Protein Signaling 2

protein · 620 words

RGS3 — Regulator of G Protein Signaling 3

gene · 613 words

RGS4 Protein

protein · 592 words

Proteins

index · 296 words

Pathway Diagram

graph TD
    RGS2["<b>RGS2</b>"]
    Parkinson{"Parkinson"}
    RGS2 -->|"interacts with"| Parkinson
    Ms{"Ms"}
    RGS2 -->|"interacts with"| Ms
    CDC42["CDC42"]
    RGS2 -->|"interacts with"| CDC42
    RAB5["RAB5"]
    RGS2 -->|"interacts with"| RAB5
    Autophagy(["Autophagy"])
    RGS2 -->|"interacts with"| Autophagy
    Mapk(["Mapk"])
    RGS2 -->|"interacts with"| Mapk
    neurodegeneration["neurodegeneration"]
    RGS2 -->|"implicated in"| neurodegeneration
    PARKINSON_S_DISEASE["PARKINSON'S DISEASE"]
    PARKINSON_S_DISEASE -->|"interacts with"| RGS2
    RAB7L1["RAB7L1"]
    RAB7L1 -->|"interacts with"| RGS2
    ARHGEF7["ARHGEF7"]
    ARHGEF7 -->|"interacts with"| RGS2
    RAC1["RAC1"]
    RAC1 -->|"interacts with"| RGS2
    LRRK2["LRRK2"]
    LRRK2 -->|"interacts with"| RGS2
    AUTOPHAGY["AUTOPHAGY"]
    AUTOPHAGY -->|"interacts with"| RGS2
    style RGS2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (11)

TargetRelationTypeStr
Parkinsoninteracts_withdisease0.65
Msinteracts_withdisease0.65
Carcinomaregulatesdisease0.65
CDC42interacts_withgene0.60
RAB5interacts_withgene0.60

Incoming (16)

SourceRelationTypeStr
RAB7L1interacts_withgene0.60
ARHGEF7interacts_withgene0.60
RAC1interacts_withgene0.60
LRRK2interacts_withgene0.60
CDC42interacts_withgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found