GABRA5

Understanding Entity Pages

This page aggregates everything SciDEX knows about GABRA5: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

GABRA5 encodes the alpha5 subunit of GABA-A receptors, predominantly expressed in hippocampus and cortex, critically involved in memory and cognition, with implications for Alzheimer's disease and cognitive enhancement.

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graph TD
    GABRA5["<b>GABRA5</b>"]
    Schizophrenia{"Schizophrenia"}
    GABRA5 -->|"associated with"| Schizophrenia
    Als{"Als"}
    GABRA5 -->|"associated with"| Als
    Depression{"Depression"}
    GABRA5 -->|"associated with"| Depression
    Bipolar{"Bipolar"}
    GABRA5 -->|"associated with"| Bipolar
    Ms{"Ms"}
    GABRA5 -->|"associated with"| Ms
    ALS{"ALS"}
    GABRA5 -->|"associated with"| ALS
    POLG["POLG"]
    GABRA5 -->|"associated with"| POLG
    TRPM2["TRPM2"]
    GABRA5 -->|"associated with"| TRPM2
    GRM3["GRM3"]
    GABRA5 -->|"associated with"| GRM3
    Circadian_Rhythm(["Circadian Rhythm"])
    GABRA5 -->|"associated with"| Circadian_Rhythm
    DAO["DAO"]
    GABRA5 -->|"associated with"| DAO
    NRG1["NRG1"]
    GABRA5 -->|"associated with"| NRG1
    HTR2A["HTR2A"]
    HTR2A -->|"associated with"| GABRA5
    DISC1["DISC1"]
    DISC1 -->|"associated with"| GABRA5
    FKBP5["FKBP5"]
    FKBP5 -->|"associated with"| GABRA5
    NRG1 -->|"associated with"| GABRA5
    DAO -->|"associated with"| GABRA5
    BMAL1["BMAL1"]
    BMAL1 -->|"associated with"| GABRA5
    GRM4["GRM4"]
    GRM4 -->|"associated with"| GABRA5
    SYNGR1["SYNGR1"]
    SYNGR1 -->|"associated with"| GABRA5
    BDNF["BDNF"]
    BDNF -->|"associated with"| GABRA5
    NCAM1["NCAM1"]
    NCAM1 -->|"associated with"| GABRA5
    RGS4["RGS4"]
    RGS4 -->|"associated with"| GABRA5
    GRIN2B["GRIN2B"]
    GRIN2B -->|"associated with"| GABRA5
    style GABRA5 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0