SNCAIP

Understanding Entity Pages

This page aggregates everything SciDEX knows about SNCAIP: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

SNCAIP (Synphilin-1) is an alpha-synuclein interacting protein that plays a critical role in protein aggregation and degradation pathways in Parkinson's disease.

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flowchart TD
    SNCAIP["SNCAIP<br/>(Synphilin-1)"]
    SNCA["SNCA<br/>(alpha-synuclein)"]
    PARKIN["PARKIN<br/>(E3 ubiquitin ligase)"]
    PRKN["PRKN<br/>(Parkin RBR E3<br/>ubiquitin ligase)"]
    
    RB1CC1["RB1CC1<br/>(FIP200/<br/>autophagy initiator)"]
    LC3["LC3<br/>(autophagosome<br/>marker)"]
    FAM134B["FAM134B<br/>(ER-phagy<br/>receptor)"]
    
    MFN1["MFN1<br/>(mitochondrial<br/>fusion)"]
    MIRO1["MIRO1<br/>(mitochondrial<br/>transport)"]
    ERN1["ERN1<br/>(ER stress<br/>sensor)"]
    
    CTSD["CTSD<br/>(cathepsin D/<br/>lysosomal enzyme)"]
    BCL2L11["BCL2L11<br/>(BIM/<br/>pro-apoptotic)"]
    
    PD["Parkinson's<br/>Disease"]
    AD["Alzheimer's<br/>Disease"]
    ALS["Amyotrophic<br/>Lateral Sclerosis"]
    FTD["Frontotemporal<br/>Dementia"]
    
    ProteinAgg["Protein<br/>Aggregation"]
    Autophagy["Autophagy<br/>Dysfunction"]
    MitoStress["Mitochondrial<br/>Dysfunction"]
    
    SNCAIP --|"forms inclusions with"|--> SNCA
    SNCAIP --|"interacts with"|--> PARKIN
    SNCAIP --|"interacts with"|--> PRKN
    
    SNCAIP --|"regulates"|--> RB1CC1
    RB1CC1 --|"initiates"|--> LC3
    SNCAIP --|"modulates"|--> FAM134B
    
    SNCAIP --|"affects"|--> MFN1
    SNCAIP --|"influences"|--> MIRO1
    SNCAIP --|"responds to"|--> ERN1
    
    SNCAIP --|"processed by"|--> CTSD
    SNCAIP --|"activates"|--> BCL2L11
    
    SNCA --|"contributes to"|--> ProteinAgg
    PARKIN --|"dysfunction leads to"|--> Autophagy
    MFN1 --|"dysfunction causes"|--> MitoStress
    
    ProteinAgg --|"pathogenesis"|--> PD
    Autophagy --|"impairment"|--> AD
    MitoStress --|"contributes to"|--> ALS
    ProteinAgg --|"involved in"|--> FTD
    
    style SNCAIP fill:#006494
    style PARKIN fill:#4a1a6b
    style PRKN fill:#4a1a6b
    style RB1CC1 fill:#1b5e20
    style LC3 fill:#1b5e20
    style CTSD fill:#1b5e20
    style PD fill:#ef5350
    style AD fill:#ef5350
    style ALS fill:#ef5350
    style FTD fill:#ef5350
    style ProteinAgg fill:#5d4400
    style Autophagy fill:#5d4400
    style MitoStress fill:#5d4400