Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about GLUL: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | GLUL |
| Full Name | Glutamate-Ammonia Ligase (Glutamine Synthetase) |
| Aliases | Glutamate-Ammonia Ligase, Glutamine Synthetase |
| Chromosome | 1q31.3 |
| Protein Type | Enzyme |
| Function | is a 392-amino acid enzyme that forms decameric complexes (10 subunits) in the cytosol. |
| Primary Expression | Astrocytes (highest), Oligodendrocytes, Neurons (low) |
| Molecular Weight | 42 kDa |
| Amino Acids | 392 aa |
| Pathways | Oxidative Stress |
| UniProt ID | P15104 |
| NCBI Gene ID | 2785 |
| Ensembl ID | ENSG00000135821 |
| OMIM | 610012 |
| GeneCards | GLUL |
| Human Protein Atlas | GLUL |
| Associated Diseases | Alzheimer's disease, Parkinson's disease |
| Interactions | TRIM25, SLC7A11, SQSTM1, GPX4, NCOA4, UBIQUITIN |
| KG Connections | 27 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
flowchart TD
GLUL(["GLUL"])
TRIM25(["TRIM25"])
Oxidative_Stress["Oxidative Stress"]
OXIDATIVE_STRESS(["OXIDATIVE STRESS"])
AND(["AND"])
FOXO3(["FOXO3"])
UBIQUITIN(["UBIQUITIN"])
neurodegeneration["neurodegeneration"]
GLUL -->|"activates"| TRIM25
GLUL -->|"activates"| Oxidative_Stress
OXIDATIVE_STRESS -->|"activates"| GLUL
AND -->|"regulates"| GLUL
FOXO3 -->|"regulates"| GLUL
UBIQUITIN -->|"activates"| GLUL
GLUL -->|"implicated in"| neurodegeneration
style GLUL fill:#1a237e,stroke:#4fc3f7,stroke-width:3px,color:#fff| Target | Relation | Type | Str |
|---|---|---|---|
| TRIM25 | activates | gene | 0.60 |
| MAPK10 | targets | gene | 0.60 |
| MAPT | targets | gene | 0.60 |
| SLC32A1 | targets | gene | 0.60 |
| MAPK10 | implicated_in | gene | 0.60 |
| MAPT | implicated_in | gene | 0.60 |
| SLC32A1 | implicated_in | gene | 0.60 |
| SLC7A11 | interacts_with | gene | 0.60 |
| SQSTM1 | interacts_with | gene | 0.60 |
| GPX4 | activates | gene | 0.60 |
| NCOA4 | activates | gene | 0.60 |
| SLC7A11 | activates | gene | 0.60 |
| SQSTM1 | activates | gene | 0.60 |
| ferroptosis | participates_in | pathway | 0.60 |
| Oxidative Stress | activates | pathway | 0.60 |
| POSTN | targets | gene | 0.60 |
| autophagy pathway | participates_in | pathway | 0.60 |
| apoptosis pathway | participates_in | pathway | 0.60 |
| MAPK signaling | participates_in | pathway | 0.60 |
| senescence | participates_in | pathway | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||