MAPK10

Understanding Entity Pages

This page aggregates everything SciDEX knows about MAPK10: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

MAPK10 (Mitogen-Activated Protein Kinase 10), also known as JNK3, is a neuronal-specific stress-activated kinase involved in apoptosis, synaptic plasticity, and neurodegeneration. It has been implicated in Alzheimer's disease, Parkinson's disease, and ...

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graph TD
    MAPK10["<b>MAPK10</b>"]
    Diabetes{"Diabetes"}
    MAPK10 -->|"therapeutic target"| Diabetes
    Als{"Als"}
    MAPK10 -->|"therapeutic target"| Als
    Atherosclerosis{"Atherosclerosis"}
    MAPK10 -->|"therapeutic target"| Atherosclerosis
    Aging{"Aging"}
    MAPK10 -->|"therapeutic target"| Aging
    Ms{"Ms"}
    MAPK10 -->|"therapeutic target"| Ms
    GENES["GENES"]
    MAPK10 -->|"therapeutic target"| GENES
    APOE["APOE"]
    MAPK10 -->|"therapeutic target"| APOE
    SIGLEC1["SIGLEC1"]
    MAPK10 -->|"associated with"| SIGLEC1
    SPR["SPR"]
    MAPK10 -->|"therapeutic target"| SPR
    Jak_Stat(["Jak-Stat"])
    MAPK10 -->|"therapeutic target"| Jak_Stat
    Nf__b(["Nf-Kappab"])
    MAPK10 -->|"therapeutic target"| Nf__b
    Mapk(["Mapk"])
    MAPK10 -->|"associated with"| Mapk
    AGING["AGING"]
    AGING -->|"therapeutic target"| MAPK10
    JAK["JAK"]
    JAK -->|"therapeutic target"| MAPK10
    SIGLEC1 -->|"associated with"| MAPK10
    NF__B["NF-KappaB"]
    NF__B -->|"therapeutic target"| MAPK10
    DIABETES_MELLITUS["DIABETES MELLITUS"]
    DIABETES_MELLITUS -->|"therapeutic target"| MAPK10
    SPR -->|"therapeutic target"| MAPK10
    APOE -->|"therapeutic target"| MAPK10
    JNK["JNK"]
    JNK -->|"activates"| MAPK10
    APOPTOSIS["APOPTOSIS"]
    APOPTOSIS -->|"activates"| MAPK10
    style MAPK10 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0