Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about slc32a1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | SLC32A1 |
| Function | SLC32A1 encodes the vesicular GABA transporter (VGAT), also known as the vesicular inhibitory amino acid transporter (VIAAT). |
| Pathways | autophagy pathway, Apoptosis, Necroptosis, Pyroptosis |
| Ensembl ID | ENSG00000103838 |
| GeneCards | SLC32A1 |
| Human Protein Atlas | SLC32A1 |
| Associated Diseases | Als, Cancer, Tumor, ALS |
| Interactions | SLC17A6, SNAP25, GRIA2, PVALB, SLC17A7 |
| KG Connections | 14 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
SLC32A1["SLC32A1"]
SLC32A1 -->|"target for"| Pyroptosis["Pyroptosis"]
SLC32A1 -->|"target for"| Necroptosis["Necroptosis"]
SLC32A1 -->|"target for"| Dementia["Dementia"]
SLC32A1 -->|"target for"| Alzheimer["Alzheimer"]
SLC32A1 -.biomarker for.-> GRIN2A["GRIN2A"]
SLC32A1 -.biomarker for.-> PVALB["PVALB"]
PYROPTOSIS["PYROPTOSIS"] -->|"target for"| SLC32A1
SLC17A7["SLC17A7"] -.biomarker for.-> SLC32A1
SLC17A6["SLC17A6"] -.biomarker for.-> SLC32A1
SLC12A5["SLC12A5"] -.biomarker for.-> SLC32A1
SYN2["SYN2"] -.biomarker for.-> SLC32A1
APOPTOSIS["APOPTOSIS"] -->|"target for"| SLC32A1
ALZHEIMER["ALZHEIMER"] -->|"target for"| SLC32A1
RNA["RNA"] -->|"target for"| SLC32A1| Target | Relation | Type | Str |
|---|---|---|---|
| SLC17A6 | associated_with | gene | 0.50 |
| SYN2 | associated_with | gene | 0.50 |
| SNAP25 | associated_with | gene | 0.50 |
| GRIN2A | associated_with | gene | 0.50 |
| SLC12A5 | associated_with | gene | 0.50 |
| PVALB | associated_with | gene | 0.50 |
| SLC17A7 | associated_with | protein | 0.50 |
| GAD1 | associated_with | gene | 0.50 |
| SLC17A6 | interacts_with | gene | 0.50 |
| SNAP25 | interacts_with | gene | 0.50 |
| GRIA2 | interacts_with | gene | 0.50 |
| PVALB | interacts_with | gene | 0.50 |
| SLC17A7 | interacts_with | protein | 0.50 |
| cancer | interacts_with | disease | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| SLC17A7 | biomarker_for | gene | 0.60 |
| SLC17A6 | biomarker_for | gene | 0.60 |
| SLC12A5 | biomarker_for | gene | 0.60 |
| SYN2 | biomarker_for | gene | 0.60 |
| GAD1 | biomarker_for | gene | 0.60 |
| SYP | biomarker_for | gene | 0.60 |
| SLC17A7 | associated_with | gene | 0.60 |
| SLC17A6 | associated_with | gene | 0.60 |
| NPY | associated_with | gene | 0.60 |
| PVALB | associated_with | gene | 0.60 |
| GRIN2A | biomarker_for | gene | 0.60 |
| SNAP25 | biomarker_for | gene | 0.60 |
| GRIA2 | associated_with | gene | 0.60 |
| PVALB | biomarker_for | gene | 0.60 |
| GRIA2 | interacts_with | gene | 0.60 |
| NPY | interacts_with | gene | 0.60 |
| PVALB | interacts_with | gene | 0.60 |
| SLC17A6 | interacts_with | gene | 0.60 |
| SLC17A7 | interacts_with | gene | 0.60 |
| GLUL | targets | gene | 0.60 |
| MAPK10 | targets | gene | 0.60 |
| MAPT | targets | gene | 0.60 |
| GLUL | implicated_in | gene | 0.60 |
| MAPK10 | implicated_in | gene | 0.60 |
| MAPT | implicated_in | gene | 0.60 |
| GAD1 | activates | gene | 0.60 |
| PYROPTOSIS | therapeutic_target | gene | 0.60 |
| APOPTOSIS | therapeutic_target | gene | 0.60 |
| ALZHEIMER | therapeutic_target | gene | 0.60 |
| RNA | therapeutic_target | gene | 0.60 |
| ASTROCYTES | therapeutic_target | gene | 0.60 |
| DEMENTIA | therapeutic_target | gene | 0.60 |
| INS | associated_with | gene | 0.60 |
| HUB GENES | biomarker_for | gene | 0.60 |
| RNA | expressed_in | gene | 0.60 |
| PYROPTOSIS | expressed_in | gene | 0.60 |
| DEMENTIA | expressed_in | gene | 0.60 |
| AND | biomarker_for | gene | 0.60 |
| ASTROCYTES | expressed_in | gene | 0.60 |
| ALZHEIMER'S DISEASE | expressed_in | gene | 0.60 |
| APOPTOSIS | expressed_in | gene | 0.60 |
| INS | interacts_with | gene | 0.60 |
| POSTN | targets | gene | 0.60 |
| benchmark_ot_ad_answer_key:SLC32A1 | data_in | dataset_row | 0.00 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||