concept

CHOLESTEROL METABOLISM

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CHOLESTEROL METABOLISM: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

365Connections

0Hypotheses

2Analyses

50Outgoing

50Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	CHOLESTEROL METABOLISM
Key Genes/Proteins	LRP1, APOE, CYP46A1, AMYLOID-BETA, APOE4, GPR146
Related Diseases	DEPRESSION, atherosclerosis
Related Pathways	Cholesterol
Linked Hypotheses	1 hypotheses

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    CHOLESTEROL_METABOLISM["CHOLESTEROL METABOLISM"]
    CHOLESTEROL_METABOLISM -->|"involved_in"| PREIMPLANTATION_DEVELOPMENT["PREIMPLANTATION DEVELOPMENT"]
    CHOLESTEROL_METABOLISM -->|"regulates"| CD8__T_Cell_Immunity["CD8+ T Cell Immunity"]
    CHOLESTEROL_METABOLISM -->|"causes"| Macrophage_Senescence["Macrophage Senescence"]
    CHOLESTEROL_METABOLISM -->|"regulates"| INFLAMMATION["INFLAMMATION"]
    CHOLESTEROL_METABOLISM -->|"inhibits"| ERK["ERK"]
    CHOLESTEROL_METABOLISM -->|"activates"| LYSOSOME["LYSOSOME"]
    CHOLESTEROL_METABOLISM -->|"regulates"| NEURON["NEURON"]
    LDLR["LDLR"] -->|"participates in"| CHOLESTEROL_METABOLISM
    SGMS1["SGMS1"] -->|"involved_in"| CHOLESTEROL_METABOLISM
    NR1H3["NR1H3"] -->|"regulates"| CHOLESTEROL_METABOLISM
    PPARGC1A["PPARGC1A"] -->|"regulates"| CHOLESTEROL_METABOLISM
    APOE["APOE"] -->|"regulates"| CHOLESTEROL_METABOLISM
    ApoE["ApoE"] -->|"regulates"| CHOLESTEROL_METABOLISM
    AGING["AGING"] -->|"regulates"| CHOLESTEROL_METABOLISM
    ABCA1["ABCA1"] -->|"activates"| CHOLESTEROL_METABOLISM

Outgoing (62)

Target	Relation	Type	Str
PREIMPLANTATION DEVELOPMENT	involved_in	entity	0.85
NEURON	interacts_with	cell_type	0.65
LRP1	regulates	gene	0.65
CYP46A1	implicated_in	gene	0.55
DEPRESSION	implicated_in	disease	0.55
CENTRAL NERVOUS SYSTEM	associated_with	concept	0.50
TREM2	associated_with	gene	0.45
ASTROCYTES	associated_with	cell_type	0.45
NEURODEGENERATION	associated_with	disease	0.45
AMYLOID-BETA	associated_with	protein	0.45
NEURONS	associated_with	cell_type	0.45
TAU	associated_with	protein	0.45
SENESCENCE	associated_with	phenotype	0.45
LRP1	associated_with	gene	0.45
INFLAMMATION	associated_with	phenotype	0.45
HUNTINGTON'S DISEASE	associated_with	disease	0.45
PARKINSON'S DISEASE	associated_with	disease	0.45
NEUROINFLAMMATION	associated_with	phenotype	0.45
NEUROGENESIS	associated_with	phenotype	0.45
FUS	associated_with	gene	0.45
ERK	associated_with	gene	0.45
APOPTOSIS	associated_with	phenotype	0.45
CERAMIDE	associated_with	phenotype	0.45
BDNF	associated_with	gene	0.45
STING	associated_with	gene	0.45
MACROPHAGES	associated_with	cell_type	0.45
FRONTAL CORTEX	associated_with	brain_region	0.45
CORTEX	associated_with	brain_region	0.45
INFLAMMATION	metabolizes	process	0.35
NEURON	regulates	cell_type	0.35
IPSC	regulates	cell_type	0.35
TAU	regulates	protein	0.35
NEURON	metabolizes	cell_type	0.35
STRIATUM	inhibits	brain_region	0.35
NEURON	inhibits	cell_type	0.35
GLIOBLASTOMA	implicated_in	disease	0.35
DEPRESSION	activates	disease	0.35
CORTEX	activates	brain_region	0.35
DEPRESSION	metabolizes	disease	0.35
DEPRESSION	causes	disease	0.35
CORTEX	causes	brain_region	0.35
SYNAPTIC PLASTICITY	activates	process	0.35
STING	regulates	gene	0.35
INFLAMMASOME	activates	protein	0.35
MACROPHAGES	regulates	cell_type	0.35
FRONTOTEMPORAL DEMENTIA	metabolizes	disease	0.35
OLIGODENDROCYTES	metabolizes	cell_type	0.35
TDP-43	metabolizes	gene	0.35
TDP-43	regulates	gene	0.35
IMMUNE RESPONSE	activates	process	0.35

Incoming (303)

Source	Relation	Type	Str
NR1H3	regulates	entity	0.85
APOE	implicated_in	gene	0.60
AMYLOID-BETA	implicated_in	protein	0.55
APOE4	activates	gene	0.50
APOE	activates	gene	0.50
Cholesterol	activates	pathway	0.50
GPR146	inhibits	gene	0.50
Cholesterol	inhibits	pathway	0.50
atherosclerosis	inhibits	disease	0.50
Cholesterol	regulates	pathway	0.50
inflammation	regulates	pathway	0.50
aging	regulates	phenotype	0.50
apoptosis	regulates	process	0.50
CERAMIDE	regulates	concept	0.50
SGMS1	regulates	concept	0.50
ALZHEIMER	associated_with	gene	0.50
Alzheimer'S Disease	associated_with	disease	0.50
Cholesterol	associated_with	pathway	0.50
disease	associated_with	disease	0.50
ALZHEIMER'S	associated_with	concept	0.50
ALZHEIMER	inhibits	gene	0.50
Alzheimer'S Disease	inhibits	disease	0.50
NEURODEGENERATIVE DISORDERS	inhibits	concept	0.50
disease	inhibits	disease	0.50
ALZHEIMER'S	inhibits	concept	0.50
ALZHEIMER	regulates	gene	0.50
Alzheimer'S Disease	regulates	disease	0.50
disease	regulates	disease	0.50
NEURONS	regulates	concept	0.50
ALZHEIMER'S	regulates	concept	0.50
AMYLOID-β	regulates	concept	0.50
IPSC	regulates	concept	0.50
CYP46A1	associated_with	gene	0.50
Neuron	associated_with	cell_type	0.50
CYP46A1	inhibits	gene	0.50
Neuron	inhibits	cell_type	0.50
NEURONS	inhibits	concept	0.50
CYP46A1	activates	gene	0.50
ALZHEIMER	activates	gene	0.50
Alzheimer'S Disease	activates	disease	0.50
disease	activates	disease	0.50
ALZHEIMER'S	activates	concept	0.50
Cholesterol	interacts_with	pathway	0.50
MITOCHONDRIA	inhibits	cell_type	0.50
Autophagy	inhibits	process	0.50
Cognitive Impairment	inhibits	phenotype	0.50
GLIOBLASTOMA	regulates	gene	0.50
CYP46A1	regulates	gene	0.50
DEPRESSION	activates	disease	0.50
NR3C1	activates	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (2)

Scientific analyses that reference this entity

What specific molecular mechanisms link APOE4 to cholesterol dysregulation in ol

neurodegeneration | 2026-04-14 | 1 hypotheses Top: 0.505

Lipid raft composition changes in synaptic neurodegeneration

neurodegeneration | 2026-04-01 | 12 hypotheses Top: 0.648

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

CHOLESTEROL METABOLISM

Understanding Entity Pages

Wiki Pages (20)

Parkinson's Disease

APOC4 — Apolipoprotein C-IV

Coenzyme Q10 for Neurodegeneration

Niemann-Pick Disease Type C (NPC)

TDP-43 Proteinopathy

metabolic-dysfunction-neurodegeneration

Lipid Metabolism Dysfunction Comparison — AD/PD/ALS/FTD/HD

Metabolomic Alterations in PSP

Peroxisomal Dysfunction

er-stress-neurodegeneration

genetics

Lipid Metabolism Dysregulation in Neurodegeneration

Amyloid Precursor Protein (APP)

Gamma-Secretase Complex (γ-Secretase)

LRP1B — Low Density Lipoprotein Receptor-Related Protein 1B

MSA Genetics and Risk Factors

niemann-pick-disease

Sphingolipid Metabolism in Neurodegeneration

Demyelination

Mechanisms Dashboard