gene

IL11

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about IL11: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

23Connections

0Hypotheses

0Analyses

12Outgoing

11Incoming

0Experiments

0Debates

Summary

IL11 is a gene implicated in neurodegeneration research. Key relationships include: activates, associated with, therapeutic target. Associated with Cancer, Fibrosis, Inflammation. Connected to 24 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	IL11
Aliases	AGIF, OPN, oprelvekin
Chromosome	19q13.4
Protein Type	IL-6 family cytokine
Function	IL-11 has diverse biological functions spanning multiple organ systems:
Primary Expression	various cell types and has been implicated in neuroinflammation, astrocyte function, and neurodegenerative diseases[@du2016][@gadient1998][@schwab2021
Molecular Weight	~19 kDa
Amino Acids	199 aa
Pathways	Apoptosis, Metastasis, Tumor Microenvironment, osteoblastogenesis
UniProt ID	P20815
NCBI Gene ID	3609
OMIM	147681
GeneCards	IL11
Human Protein Atlas	IL11
Protein Class	IL-6 family cytokine
Associated Diseases	neurodegeneration
Interactions	IL11R, EGFR, CD8, APOPTOSIS, CANCER, ASTROCYTES
KG Connections	23 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: IL11 — AlphaFold P20815 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

IL11 Gene

gene · 2024 words

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Genes

index · 271 words

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Pathway Diagram

graph TD
    IL11["<b>IL11</b>"]
    osteoblastogenesis(["osteoblastogenesis"])
    IL11 -->|"activates"| osteoblastogenesis
    IL11R["IL11R"]
    IL11 -->|"interacts with"| IL11R
    Fibrosis{"Fibrosis"}
    IL11 -->|"therapeutic target"| Fibrosis
    Inflammation{"Inflammation"}
    IL11 -->|"therapeutic target"| Inflammation
    STAT3["STAT3"]
    IL11 -->|"associated with"| STAT3
    Mtor(["Mtor"])
    IL11 -->|"associated with"| Mtor
    neurodegeneration["neurodegeneration"]
    IL11 -->|"implicated in"| neurodegeneration
    MTOR["MTOR"]
    MTOR -->|"associated with"| IL11
    ERK["ERK"]
    ERK -->|"associated with"| IL11
    IL6["IL6"]
    IL6 -->|"associated with"| IL11
    JAK["JAK"]
    JAK -->|"associated with"| IL11
    CYTOKINES["CYTOKINES"]
    CYTOKINES -->|"associated with"| IL11
    INFLAMMATION["INFLAMMATION"]
    INFLAMMATION -->|"therapeutic target"| IL11
    style IL11 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (12)

Target	Relation	Type	Str
osteoblastogenesis	activates	pathway	0.90
IL11R	interacts_with	protein	0.76
Fibrosis	therapeutic_target	disease	0.65
Inflammation	therapeutic_target	disease	0.65
Tumor	activates	disease	0.65
Cancer	activates	disease	0.65
Lung Cancer	activates	disease	0.65
STAT3	associated_with	gene	0.60
Mtor	associated_with	pathway	0.60
Metastasis	activates	pathway	0.60
Apoptosis	activates	pathway	0.60
Tumor Microenvironment	activates	pathway	0.60

Incoming (11)

Source	Relation	Type	Str
MTOR	associated_with	gene	0.60
IL6	associated_with	gene	0.60
EGFR	activates	gene	0.60
CD8	activates	gene	0.60
ERK	associated_with	gene	0.60
JAK	associated_with	gene	0.60
CYTOKINES	associated_with	gene	0.60
INFLAMMATION	therapeutic_target	gene	0.60
APOPTOSIS	activates	gene	0.60
CANCER	activates	gene	0.60
ASTROCYTES	activates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity