Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about IL18BP: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
IL18BP is a gene implicated in neurodegeneration research. Key relationships include: inhibits, associated with, expressed in. Associated with Ms. Connected to 18 entities in the SciDEX knowledge graph.
| Gene Symbol | IL18BP |
| Full Name | Interleukin 18 Binding Protein |
| Chromosome | 11p15 |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Primary Expression | various tissues throughout the body, with distinct patterns in the brain: |
| Molecular Weight | 40 kDa |
| Amino Acids | 100 aa |
| Pathways | NF-κB, MAPK signaling |
| UniProt ID | [O95298](https://www.uniprot.org/uniprot/O95298) |
| Ensembl ID | ENSG00000147421 |
| GeneCards | IL18BP |
| Human Protein Atlas | IL18BP |
| Immunoglobulin-like domain | Single V-type Ig domain (~100 amino acids) |
| Molecular weight | Approximately 40 kDa |
| Secretion | Constitutively secreted by various cell types |
| Associated Diseases | neurodegeneration |
| Interactions | BDNF, FKBP5, CRHR1, CRH, NR3C1, TLR4 |
| KG Connections | 63 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
IL18BP["<b>IL18BP</b>"]
Ms{"Ms"}
IL18BP -->|"inhibits"| Ms
CALCA["CALCA"]
IL18BP -->|"associated with"| CALCA
BDNF["BDNF"]
IL18BP -->|"inhibits"| BDNF
FKBP5["FKBP5"]
IL18BP -->|"inhibits"| FKBP5
IL18["IL18"]
IL18BP -->|"associated with"| IL18
CRHR1["CRHR1"]
IL18BP -->|"inhibits"| CRHR1
Amygdala["Amygdala"]
IL18BP -->|"expressed in"| Amygdala
Neuron["Neuron"]
IL18BP -->|"expressed in"| Neuron
neurodegeneration["neurodegeneration"]
IL18BP -->|"implicated in"| neurodegeneration
IL18 -->|"associated with"| IL18BP
RAMP1["RAMP1"]
RAMP1 -->|"associated with"| IL18BP
FKBP5 -->|"inhibits"| IL18BP
CRH["CRH"]
CRH -->|"inhibits"| IL18BP
CRHR1 -->|"inhibits"| IL18BP
NR3C1["NR3C1"]
NR3C1 -->|"inhibits"| IL18BP
BDNF -->|"inhibits"| IL18BP
CALCA -->|"associated with"| IL18BP
GENES["GENES"]
GENES -->|"associated with"| IL18BP
AND["AND"]
AND -->|"associated with"| IL18BP
style IL18BP fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Oxaliplatin-Induced Peripheral Neuropathy | protects_against | disease | 0.90 |
| Ptsd | inhibits | disease | 0.65 |
| Ms | inhibits | disease | 0.65 |
| Tumor | activates | disease | 0.65 |
| Cancer | activates | disease | 0.65 |
| Neuropathy | activates | disease | 0.65 |
| CALCA | associated_with | gene | 0.60 |
| BDNF | inhibits | gene | 0.60 |
| FKBP5 | inhibits | gene | 0.60 |
| IL18 | associated_with | gene | 0.60 |
| CRHR1 | inhibits | gene | 0.60 |
| RAMP1 | interacts_with | entity | 0.60 |
| NLRP3 | activates | entity | 0.60 |
| CRH | inhibits | gene | 0.60 |
| NR3C1 | inhibits | gene | 0.60 |
| TLR4 | activates | gene | 0.60 |
| IL18 | causes | gene | 0.60 |
| NLRP3 | causes | gene | 0.60 |
| JNK | activates | gene | 0.60 |
| IL18 | therapeutic_target | gene | 0.60 |
| Rb | inhibits | protein | 0.60 |
| AND | associated_with | gene | 0.60 |
| NLR | causes | gene | 0.60 |
| AND | causes | gene | 0.60 |
| CANCER | activates | gene | 0.60 |
| Inflammasome | activates | pathway | 0.60 |
| Neuron | inhibits | cell_type | 0.60 |
| NLR | activates | gene | 0.60 |
| Macrophage | activates | cell_type | 0.60 |
| GENES | associated_with | gene | 0.60 |
| Bdnf | inhibits | protein | 0.60 |
| Neutrophil | activates | cell_type | 0.60 |
| App | associated_with | protein | 0.60 |
| Amygdala | expressed_in | brain_region | 0.55 |
| Neuron | expressed_in | cell_type | 0.55 |
| Macrophage | expressed_in | cell_type | 0.55 |
| JNK | co_expressed_with | protein | 0.50 |
| NLR | co_expressed_with | gene | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| IL18 | associated_with | gene | 0.60 |
| RAMP1 | associated_with | gene | 0.60 |
| FKBP5 | inhibits | gene | 0.60 |
| CRH | inhibits | gene | 0.60 |
| CRHR1 | inhibits | gene | 0.60 |
| NR3C1 | inhibits | gene | 0.60 |
| BDNF | inhibits | gene | 0.60 |
| CALCA | associated_with | gene | 0.60 |
| CALCA | interacts_with | entity | 0.60 |
| IL18 | interacts_with | entity | 0.60 |
| IL18 | treats | entity | 0.60 |
| IL18 | activates | entity | 0.60 |
| NLRP3 | causes | gene | 0.60 |
| IL18 | causes | gene | 0.60 |
| TLR4 | activates | gene | 0.60 |
| NLRP3 | activates | gene | 0.60 |
| IL18 | therapeutic_target | gene | 0.60 |
| GENES | associated_with | gene | 0.60 |
| AND | associated_with | gene | 0.60 |
| CANCER | activates | gene | 0.60 |
| NLR | causes | gene | 0.60 |
| NLR | activates | gene | 0.60 |
| RAMP1 | interacts_with | gene | 0.50 |
| IL18 | protects_against | gene | 0.50 |
| IL18 | co_expressed_with | gene | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||