gene

IL18BP

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about IL18BP: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

63Connections
0Hypotheses
0Analyses
38Outgoing
25Incoming

Summary

IL18BP is a gene implicated in neurodegeneration research. Key relationships include: inhibits, associated with, expressed in. Associated with Ms. Connected to 18 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolIL18BP
Full NameInterleukin 18 Binding Protein
Chromosome11p15
Functionis an important component in the neurobiology of neurodegenerative diseases.
Primary Expressionvarious tissues throughout the body, with distinct patterns in the brain:
Molecular Weight40 kDa
Amino Acids100 aa
PathwaysNF-κB, MAPK signaling
UniProt ID[O95298](https://www.uniprot.org/uniprot/O95298)
Ensembl IDENSG00000147421
GeneCardsIL18BP
Human Protein AtlasIL18BP
Immunoglobulin-like domainSingle V-type Ig domain (~100 amino acids)
Molecular weightApproximately 40 kDa
SecretionConstitutively secreted by various cell types
Associated Diseasesneurodegeneration
InteractionsBDNF, FKBP5, CRHR1, CRH, NR3C1, TLR4
KG Connections63 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING

Wiki Pages (7)

Knowledge base pages for this entity

Canonical Page

IL18BP Gene

gene · 1200 words

Interleukin-18 Protein

protein · 1299 words

IL18 Gene

gene · 1169 words

CALCA Gene

gene · 820 words

IL-18BP Protein

protein · 578 words

Proteins

index · 296 words

Pathway Diagram

graph TD
    IL18BP["<b>IL18BP</b>"]
    Ms{"Ms"}
    IL18BP -->|"inhibits"| Ms
    CALCA["CALCA"]
    IL18BP -->|"associated with"| CALCA
    BDNF["BDNF"]
    IL18BP -->|"inhibits"| BDNF
    FKBP5["FKBP5"]
    IL18BP -->|"inhibits"| FKBP5
    IL18["IL18"]
    IL18BP -->|"associated with"| IL18
    CRHR1["CRHR1"]
    IL18BP -->|"inhibits"| CRHR1
    Amygdala["Amygdala"]
    IL18BP -->|"expressed in"| Amygdala
    Neuron["Neuron"]
    IL18BP -->|"expressed in"| Neuron
    neurodegeneration["neurodegeneration"]
    IL18BP -->|"implicated in"| neurodegeneration
    IL18 -->|"associated with"| IL18BP
    RAMP1["RAMP1"]
    RAMP1 -->|"associated with"| IL18BP
    FKBP5 -->|"inhibits"| IL18BP
    CRH["CRH"]
    CRH -->|"inhibits"| IL18BP
    CRHR1 -->|"inhibits"| IL18BP
    NR3C1["NR3C1"]
    NR3C1 -->|"inhibits"| IL18BP
    BDNF -->|"inhibits"| IL18BP
    CALCA -->|"associated with"| IL18BP
    GENES["GENES"]
    GENES -->|"associated with"| IL18BP
    AND["AND"]
    AND -->|"associated with"| IL18BP
    style IL18BP fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (38)

TargetRelationTypeStr
Oxaliplatin-Induced Peripheral Neuropathyprotects_againstdisease0.90
Ptsdinhibitsdisease0.65
Msinhibitsdisease0.65
Tumoractivatesdisease0.65
Canceractivatesdisease0.65

Incoming (25)

SourceRelationTypeStr
IL18associated_withgene0.60
RAMP1associated_withgene0.60
FKBP5inhibitsgene0.60
CRHinhibitsgene0.60
CRHR1inhibitsgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found