gene

RAMP1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RAMP1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

59Connections

0Hypotheses

0Analyses

33Outgoing

26Incoming

Summary

Receptor Activity Modifying Protein 1 - essential for CGRP and amylin receptor formation, with roles in migraine, neuroprotection, and potential therapeutic implications for Alzheimer's and Parkinson's disease

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🧬 Gene Info

Gene Symbol	RAMP1
Aliases	Receptor Activity Modifying Protein 1
Chromosome	2q36.1
Protein Type	Chaperone
Function	encodes a single-pass membrane protein that functions as an essential chaperone for G protein-coupled receptors (GPCRs).
Primary Expression	sensory neurons, the brain, cardiovascular system, and immune cells
Amino Acids	175 aa
Exons	6
Ensembl ID	ENSG00000132329
GeneCards	RAMP1
Human Protein Atlas	RAMP1
N-terminal extracellular domain	Large extracellular N-terminus (~130 amino acids) that forms the ligand-binding pocket with the GPCR
Single transmembrane helix	A 22-amino acid hydrophobic transmembrane domain anchoring RAMP1 to the cell membrane
C-terminal intracellular tail	Short cytoplasmic domain (~10 amino acids)
Sensory neurons	Highest expression in trigeminal ganglion and dorsal root ganglia
Associated Diseases	ALS, Alzheimer, Atherosclerosis
Interactions	FKBP5, CRH, CRHR1, NR3C1, BDNF, IL18BP
KG Connections	59 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (20)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    RAMP1["<b>RAMP1</b>"]
    Ms{"Ms"}
    RAMP1 -->|"inhibits"| Ms
    FKBP5["FKBP5"]
    RAMP1 -->|"inhibits"| FKBP5
    CRH["CRH"]
    RAMP1 -->|"inhibits"| CRH
    CRHR1["CRHR1"]
    RAMP1 -->|"inhibits"| CRHR1
    NR3C1["NR3C1"]
    RAMP1 -->|"inhibits"| NR3C1
    BDNF["BDNF"]
    RAMP1 -->|"inhibits"| BDNF
    IL18BP["IL18BP"]
    RAMP1 -->|"associated with"| IL18BP
    CALCA["CALCA"]
    RAMP1 -->|"associated with"| CALCA
    GENES["GENES"]
    RAMP1 -->|"associated with"| GENES
    IL18["IL18"]
    RAMP1 -->|"associated with"| IL18
    AND["AND"]
    RAMP1 -->|"associated with"| AND
    Amygdala["Amygdala"]
    RAMP1 -->|"expressed in"| Amygdala
    IL18 -->|"associated with"| RAMP1
    CRHR1 -->|"inhibits"| RAMP1
    CALCA -->|"associated with"| RAMP1
    BDNF -->|"inhibits"| RAMP1
    GENES -->|"associated with"| RAMP1
    NR3C1 -->|"inhibits"| RAMP1
    FKBP5 -->|"inhibits"| RAMP1
    CRH -->|"inhibits"| RAMP1
    style RAMP1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (33)

Target	Relation	Type	Str
Atherosclerosis	biomarker_for	disease	0.85
Ptsd	inhibits	disease	0.65
Ms	inhibits	disease	0.65
Alzheimer	associated_with	disease	0.65
Als	associated_with	disease	0.65
Atherosclerosis	associated_with	disease	0.65
ALS	associated_with	disease	0.65
FKBP5	inhibits	gene	0.60
CRH	inhibits	gene	0.60
CRHR1	inhibits	gene	0.60
NR3C1	inhibits	gene	0.60
BDNF	inhibits	gene	0.60
IL18BP	associated_with	gene	0.60
CALCA	associated_with	gene	0.60
IL18	associated_with	gene	0.60
C1QB	associated_with	gene	0.60
TYROBP	associated_with	gene	0.60
CSF1R	associated_with	gene	0.60
C1QA	biomarker_for	gene	0.60
Rb	inhibits	protein	0.60
GENES	associated_with	gene	0.60
AND	associated_with	gene	0.60
Neuron	inhibits	cell_type	0.60
ALZHEIMER	associated_with	gene	0.60
Bdnf	inhibits	protein	0.60
AND	biomarker_for	gene	0.60
GENES	biomarker_for	gene	0.60
App	associated_with	protein	0.60
Amygdala	expressed_in	brain_region	0.55
Neuron	expressed_in	cell_type	0.55
IL18BP	interacts_with	gene	0.50
C1QA	associated_with	gene	0.50
TYROBP	co_expressed_with	gene	0.50

Incoming (26)

Source	Relation	Type	Str
IL18	associated_with	gene	0.60
CRHR1	inhibits	gene	0.60
CALCA	associated_with	gene	0.60
BDNF	inhibits	gene	0.60
NR3C1	inhibits	gene	0.60
FKBP5	inhibits	gene	0.60
CRH	inhibits	gene	0.60
CALCA	interacts_with	entity	0.60
IL18	interacts_with	entity	0.60
IL18BP	interacts_with	entity	0.60
CSF1R	associated_with	gene	0.60
C1QB	associated_with	gene	0.60
C1QA	biomarker_for	gene	0.60
TYROBP	associated_with	gene	0.60
C1QA	associated_with	gene	0.60
CREB1	activates	gene	0.60
GENES	associated_with	gene	0.60
AND	associated_with	gene	0.60
GENES	biomarker_for	gene	0.60
ALZHEIMER	associated_with	gene	0.60
AND	biomarker_for	gene	0.60
ALZHEIMER'S DISEASE	associated_with	gene	0.60
HUB GENES	associated_with	gene	0.60
PKA	activates	gene	0.60
C1QB	co_expressed_with	gene	0.50
CSF1R	co_expressed_with	gene	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

RAMP1

Understanding Entity Pages

Summary

Wiki Pages (20)

RAMP1

Amylin Signaling in Neurodegeneration

RAMP2 — Receptor Activity Modifying Protein 2

CALCA Protein — Calcitonin Gene-Related Peptide

ramp1-protein

CGRP Receptor Modulators in Neurodegeneration

ramp3-protein

Calcitonin Receptor Protein

RAMP3 — Receptor Activity Modifying Protein 3

CALCR — Calcitonin Receptor

amylin-pramlintide-therapy-neurodegeneration

RAMP2 Protein

CGRP Neurons

Parabrachial Nucleus in Autism Spectrum Disorder

CALCA Gene

Calcitonin Gene-Related Peptide (CGRP) Neurons

CGRP Calcitonin Gene-Related Peptide Neurons

Meningeal Neurons

Proteins

Genes

Pathway Diagram

Outgoing (33)

Incoming (26)

Targeting Hypotheses (0)

Mentioning Analyses (0)

Related Papers (0)