Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about NLRP2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
NLRP2 is a NOD-like receptor protein that forms inflammasome complexes and regulates neuroinflammation in Alzheimer's disease, Parkinson's disease, and epilepsy
| Gene Symbol | NLRP2 |
| Full Name | NLR Family Pyrin Domain Containing 2 |
| Chromosome | 19q13.42 |
| Protein Type | Receptor |
| Function | is a member of the NOD-like receptor (NLR) family that plays critical roles in innate immunity and inflammasome formation. |
| Primary Expression | neurons, astrocytes, and microglia, where it participates in t |
| Molecular Weight | 114 kDa |
| Amino Acids | 975 aa |
| Exons | 10 |
| Pathways | Inflammasome, Innate Immunity, pyroptosis |
| Ensembl ID | ENSG00000163352 |
| GeneCards | NLRP2 |
| Human Protein Atlas | NLRP2 |
| Phosphorylation | Kinases including PKR and CK2 can phosphorylate NLRP2 |
| Ubiquitination | NLRP2 is subject to both K63-linked and linear ubiquitination |
| Associated Diseases | Autoimmune |
| Interactions | NLRP6, NLRP7, NLRP12, CARD8, NLRP1, NLRP3 |
| KG Connections | 44 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
NLRP2["<b>NLRP2</b>"]
Als{"Als"}
NLRP2 -->|"expressed in"| Als
Aging{"Aging"}
NLRP2 -->|"expressed in"| Aging
Ms{"Ms"}
NLRP2 -->|"expressed in"| Ms
Inflammation{"Inflammation"}
NLRP2 -->|"expressed in"| Inflammation
ASC["ASC"]
NLRP2 -->|"expressed in"| ASC
CYTOKINES["CYTOKINES"]
NLRP2 -->|"expressed in"| CYTOKINES
INFLAMMATION["INFLAMMATION"]
NLRP2 -->|"expressed in"| INFLAMMATION
AIM2["AIM2"]
NLRP2 -->|"expressed in"| AIM2
NLRP3["NLRP3"]
NLRP2 -->|"expressed in"| NLRP3
Inflammasome(["Inflammasome"])
NLRP2 -->|"expressed in"| Inflammasome
Immune_Response(["Immune Response"])
NLRP2 -->|"expressed in"| Immune_Response
neurodegeneration["neurodegeneration"]
NLRP2 -->|"implicated in"| neurodegeneration
NLRP1["NLRP1"]
NLRP1 -->|"expressed in"| NLRP2
style NLRP2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Als | expressed_in | disease | 0.65 |
| Aging | expressed_in | disease | 0.65 |
| Ms | expressed_in | disease | 0.65 |
| Inflammation | expressed_in | disease | 0.65 |
| Autoimmune | implicated_in | disease | 0.65 |
| Ms | activates | disease | 0.65 |
| Autoimmune | activates | disease | 0.65 |
| ASC | expressed_in | gene | 0.60 |
| AIM2 | expressed_in | gene | 0.60 |
| NLRP3 | expressed_in | gene | 0.60 |
| GAIN | implicated_in | gene | 0.60 |
| NLRP6 | activates | gene | 0.60 |
| NLRP7 | activates | gene | 0.60 |
| NLRP12 | activates | gene | 0.60 |
| CARD8 | activates | gene | 0.60 |
| NLRP1 | activates | gene | 0.60 |
| NLRP3 | activates | gene | 0.60 |
| PANX1 | activates | gene | 0.60 |
| CYTOKINES | expressed_in | gene | 0.60 |
| INFLAMMATION | expressed_in | gene | 0.60 |
| Inflammasome | expressed_in | pathway | 0.60 |
| Immune Response | expressed_in | pathway | 0.60 |
| NEURODEGENERATIVE DISEASES | implicated_in | gene | 0.60 |
| Innate Immunity | implicated_in | pathway | 0.60 |
| Inflammasome | activates | pathway | 0.60 |
| AND | activates | gene | 0.60 |
| NEURODEGENERATIVE DISEASES | activates | gene | 0.60 |
| Innate Immunity | activates | pathway | 0.60 |
| pyroptosis | participates_in | pathway | 0.60 |
| NLRP3 | co_expressed_with | protein | 0.50 |
| NLRP6 | co_expressed_with | gene | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| NLRP1 | expressed_in | gene | 0.60 |
| NLRP3 | activates | gene | 0.60 |
| NLRP1 | activates | gene | 0.60 |
| GAIN | activates | gene | 0.60 |
| CARD8 | activates | gene | 0.60 |
| NLRP6 | activates | gene | 0.60 |
| NLRP7 | activates | gene | 0.60 |
| NLRP12 | activates | gene | 0.60 |
| NLRP10 | activates | gene | 0.60 |
| AND | activates | gene | 0.60 |
| NEURODEGENERATIVE DISEASES | activates | gene | 0.60 |
| NLRP1 | co_expressed_with | protein | 0.50 |
| NLRP12 | co_expressed_with | gene | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||