gene

NLRP2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NLRP2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

44Connections
0Hypotheses
0Analyses
31Outgoing
13Incoming

Summary

NLRP2 is a NOD-like receptor protein that forms inflammasome complexes and regulates neuroinflammation in Alzheimer's disease, Parkinson's disease, and epilepsy

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🧬 Gene Info
Gene SymbolNLRP2
Full NameNLR Family Pyrin Domain Containing 2
Chromosome19q13.42
Protein TypeReceptor
Functionis a member of the NOD-like receptor (NLR) family that plays critical roles in innate immunity and inflammasome formation.
Primary Expressionneurons, astrocytes, and microglia, where it participates in t
Molecular Weight114 kDa
Amino Acids975 aa
Exons10
PathwaysInflammasome, Innate Immunity, pyroptosis
Ensembl IDENSG00000163352
GeneCardsNLRP2
Human Protein AtlasNLRP2
PhosphorylationKinases including PKR and CK2 can phosphorylate NLRP2
UbiquitinationNLRP2 is subject to both K63-linked and linear ubiquitination
Associated DiseasesAutoimmune
InteractionsNLRP6, NLRP7, NLRP12, CARD8, NLRP1, NLRP3
KG Connections44 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Wiki Pages (7)

Knowledge base pages for this entity

Canonical Page

NLRP2 — NLR Family Pyrin Domain Containing 2

gene · 1580 words

dapansutrile-parkinsons-disease

therapeutic · 2461 words

NLRP3 Inflammasome Inhibitors for Parkinson's Disease

mechanism · 2164 words

Neteo Therapeutics

company · 665 words

NLRP2 Protein — NLR Family Pyrin Domain Containing 2

protein · 649 words

Proteins

index · 296 words

Pathway Diagram

graph TD
    NLRP2["<b>NLRP2</b>"]
    Als{"Als"}
    NLRP2 -->|"expressed in"| Als
    Aging{"Aging"}
    NLRP2 -->|"expressed in"| Aging
    Ms{"Ms"}
    NLRP2 -->|"expressed in"| Ms
    Inflammation{"Inflammation"}
    NLRP2 -->|"expressed in"| Inflammation
    ASC["ASC"]
    NLRP2 -->|"expressed in"| ASC
    CYTOKINES["CYTOKINES"]
    NLRP2 -->|"expressed in"| CYTOKINES
    INFLAMMATION["INFLAMMATION"]
    NLRP2 -->|"expressed in"| INFLAMMATION
    AIM2["AIM2"]
    NLRP2 -->|"expressed in"| AIM2
    NLRP3["NLRP3"]
    NLRP2 -->|"expressed in"| NLRP3
    Inflammasome(["Inflammasome"])
    NLRP2 -->|"expressed in"| Inflammasome
    Immune_Response(["Immune Response"])
    NLRP2 -->|"expressed in"| Immune_Response
    neurodegeneration["neurodegeneration"]
    NLRP2 -->|"implicated in"| neurodegeneration
    NLRP1["NLRP1"]
    NLRP1 -->|"expressed in"| NLRP2
    style NLRP2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (31)

TargetRelationTypeStr
Alsexpressed_indisease0.65
Agingexpressed_indisease0.65
Msexpressed_indisease0.65
Inflammationexpressed_indisease0.65
Autoimmuneimplicated_indisease0.65

Incoming (13)

SourceRelationTypeStr
NLRP1expressed_ingene0.60
NLRP3activatesgene0.60
NLRP1activatesgene0.60
GAINactivatesgene0.60
CARD8activatesgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found