Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about NLRP7: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | NLRP7 |
| Full Name | NLR Family Pyrin Domain Containing 7 |
| Aliases | NOD27, CLR19.9 |
| Chromosome | 19q13.42 |
| Protein Type | Receptor |
| Function | is a member of the NOD-like receptor (NLR) family of proteins that plays complex roles in innate immunity, inflammation, and cellular homeostasis. |
| Amino Acids | 956 aa |
| Exons | 10 |
| Pathways | Inflammasome, Innate Immunity, pyroptosis |
| UniProt ID | Q8WX94 |
| NCBI Gene ID | 199713 |
| Ensembl ID | ENSG00000124313 |
| OMIM | 609434 |
| GeneCards | NLRP7 |
| Human Protein Atlas | NLRP7 |
| Associated Diseases | Autoimmune |
| Interactions | NLRP12, CARD8, NLRP1, GAIN, NLRP3, NLRP2 |
| KG Connections | 47 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
NLRP7["NLRP7"]
Autoimmune{"Autoimmune"}
NLRP7 -->|"implicated_in"| Autoimmune
Ms{"Ms"}
NLRP7 -->|"activates"| Ms
NLRP7 -->|"activates"| Autoimmune
NLRP12["NLRP12"]
NLRP7 -->|"activates"| NLRP12
CARD8["CARD8"]
NLRP7 -->|"activates"| CARD8
Innate_Immunity(["Innate Immunity"])
NLRP7 -->|"implicated_in"| Innate_Immunity
Inflammasome(["Inflammasome"])
NLRP7 -->|"activates"| Inflammasome
NLRP1["NLRP1"]
NLRP7 -->|"activates"| NLRP1
AND["AND"]
NLRP7 -->|"activates"| AND
NEURODEGENERATIVE_DISEASES["NEURODEGENERATIVE DISEASES"]
NLRP7 -->|"activates"| NEURODEGENERATIVE_DISEASES
NLRP7 -->|"activates"| Innate_Immunity
NLRP3["NLRP3"]
NLRP3 -->|"activates"| NLRP7
NLRP1 -->|"activates"| NLRP7
NLRP2["NLRP2"]
NLRP2 -->|"activates"| NLRP7
GAIN["GAIN"]
GAIN -->|"implicated_in"| NLRP7| Target | Relation | Type | Str |
|---|---|---|---|
| Autoimmune | implicated_in | disease | 0.65 |
| Ms | activates | disease | 0.65 |
| Autoimmune | activates | disease | 0.65 |
| Pyroptosis | interacts_with | disease | 0.65 |
| NLRP12 | activates | gene | 0.60 |
| CARD8 | activates | gene | 0.60 |
| NLRP1 | activates | gene | 0.60 |
| GAIN | activates | gene | 0.60 |
| NLRP3 | activates | gene | 0.60 |
| NLRP2 | activates | gene | 0.60 |
| NLRP6 | activates | gene | 0.60 |
| AIM2 | interacts_with | gene | 0.60 |
| CARD8 | associated_with | gene | 0.60 |
| NLRP12 | associated_with | gene | 0.60 |
| NLRP1 | associated_with | gene | 0.60 |
| NLRP6 | associated_with | gene | 0.60 |
| NLRP3 | interacts_with | gene | 0.60 |
| Innate Immunity | implicated_in | pathway | 0.60 |
| Inflammasome | activates | pathway | 0.60 |
| AND | activates | gene | 0.60 |
| NEURODEGENERATIVE DISEASES | activates | gene | 0.60 |
| Innate Immunity | activates | pathway | 0.60 |
| IL-18 | interacts_with | gene | 0.60 |
| ROS | interacts_with | gene | 0.60 |
| CYTOKINES | interacts_with | gene | 0.60 |
| IL-1 | interacts_with | gene | 0.60 |
| PYROPTOSIS | interacts_with | gene | 0.60 |
| Inflammasome | associated_with | pathway | 0.60 |
| Caspase | interacts_with | protein | 0.60 |
| Cytokine | interacts_with | protein | 0.60 |
| pyroptosis | participates_in | pathway | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| NLRP3 | activates | gene | 0.60 |
| NLRP1 | activates | gene | 0.60 |
| NLRP2 | activates | gene | 0.60 |
| GAIN | implicated_in | gene | 0.60 |
| NLRP6 | activates | gene | 0.60 |
| GAIN | activates | gene | 0.60 |
| CARD8 | activates | gene | 0.60 |
| NLRP12 | activates | gene | 0.60 |
| NLRP10 | activates | gene | 0.60 |
| CARD8 | associated_with | gene | 0.60 |
| NLRP10 | associated_with | gene | 0.60 |
| NLRP12 | associated_with | gene | 0.60 |
| NLRP6 | associated_with | gene | 0.60 |
| NEURODEGENERATIVE DISEASES | implicated_in | gene | 0.60 |
| NLRP3 | co_expressed_with | protein | 0.50 |
| NLRP6 | co_expressed_with | gene | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||