Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about NTF3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | NTF3 |
| Full Name | Neurotrophin-3 |
| Chromosome | 12p13.31 |
| Function | Neurotrophin-3 (NT-3) is a member of the neurotrophin family of growth factors, which includes NGF, BDNF, and NT-4. |
| Molecular Weight | 13.5 kDa |
| Amino Acids | 119 aa |
| Pathways | PI3K, MAPK |
| UniProt ID | P20783 |
| NCBI Gene ID | 4902 |
| Ensembl ID | ENSG00000185652 |
| GeneCards | NTF3 |
| Human Protein Atlas | NTF3 |
| Approach | Status |
| Recombinant NT-3 | Clinical trials |
| AAV-NT3 gene therapy | Preclinical |
| Associated Diseases | Alzheimer's Disease, Peripheral Neuropathy, Multiple Sclerosis |
| Interactions | CALB2, CALB1, PVALB, S100B, GFAP, FOS |
| KG Connections | 43 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
NTF3["NTF3"]
CALB2["CALB2"]
ASTROCYTES["ASTROCYTES"]
CALB1["CALB1"]
PVALB["PVALB"]
S100B["S100B"]
GFAP["GFAP"]
Mapk["Mapk"]
Neuron["Neuron"]
Astrocyte["Astrocyte"]
MAPK1["MAPK1"]
CREB1["CREB1"]
NTRK3["NTRK3"]
EGR1["EGR1"]
FOS["FOS"]
NTRK2["NTRK2"]
BDNF["BDNF"]
GAD1["GAD1"]
neurodegeneration["neurodegeneration"]
NTF3 -->|"activates"| CALB2
NTF3 -->|"activates"| ASTROCYTES
NTF3 -->|"activates"| CALB1
NTF3 -->|"activates"| PVALB
NTF3 -->|"activates"| S100B
NTF3 -->|"activates"| GFAP
NTF3 -->|"activates"| Mapk
NTF3 -.-|"associated"| Neuron
NTF3 -->|"activates"| Astrocyte
MAPK1 -->|"activates"| NTF3
CREB1 -->|"activates"| NTF3
NTRK3 -.-|"associated"| NTF3
EGR1 -->|"activates"| NTF3
FOS -->|"activates"| NTF3
NTRK2 -->|"activates"| NTF3
BDNF -.-|"associated"| NTF3
GAD1 -->|"activates"| NTF3
NTF3 -->|"implicated_in"| neurodegeneration
style NTF3 fill:#006494,stroke:#333,color:#e0e0e0,stroke-width:2px| Target | Relation | Type | Str |
|---|---|---|---|
| CALB2 | activates | gene | 0.60 |
| CALB1 | activates | gene | 0.60 |
| PVALB | activates | gene | 0.60 |
| S100B | activates | gene | 0.60 |
| GFAP | activates | gene | 0.60 |
| FOS | activates | gene | 0.60 |
| EGR1 | activates | gene | 0.60 |
| NTRK2 | activates | gene | 0.60 |
| MAPK1 | activates | gene | 0.60 |
| NTRK3 | associated_with | gene | 0.60 |
| BDNF | associated_with | gene | 0.60 |
| CREB1 | activates | gene | 0.60 |
| GAD1 | activates | gene | 0.60 |
| NTRK2 | associated_with | gene | 0.60 |
| S100B | associated_with | gene | 0.60 |
| ASTROCYTES | activates | gene | 0.60 |
| Mapk | activates | pathway | 0.60 |
| Neuron | associated_with | cell_type | 0.60 |
| Astrocyte | activates | cell_type | 0.60 |
| AND | associated_with | gene | 0.60 |
| Bdnf | associated_with | protein | 0.60 |
| neurons | expressed_in | cell_type | 0.60 |
| Astrocyte | expressed_in | cell_type | 0.55 |
| Neuron | expressed_in | cell_type | 0.55 |
| NTRK3 | interacts_with | gene | 0.50 |
| NEURONS | interacts_with | concept | 0.50 |
| Synaptic Transmission | interacts_with | pathway | 0.50 |
| Proteins | interacts_with | protein | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| MAPK1 | activates | gene | 0.60 |
| CREB1 | activates | gene | 0.60 |
| NTRK3 | associated_with | gene | 0.60 |
| EGR1 | activates | gene | 0.60 |
| FOS | activates | gene | 0.60 |
| NTRK2 | activates | gene | 0.60 |
| BDNF | associated_with | gene | 0.60 |
| GAD1 | activates | gene | 0.60 |
| GFAP | activates | gene | 0.60 |
| CALB1 | activates | gene | 0.60 |
| S100B | activates | gene | 0.60 |
| BDNF | co_discussed | gene | 0.60 |
| GFAP | associated_with | gene | 0.60 |
| MAPK1 | associated_with | gene | 0.60 |
| BDNF | interacts_with | gene | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||