Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about NTRK3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
NTRK3 is a gene implicated in neurodegeneration research. Key relationships include: contributes to, associated with, activates. Associated with ALS, Als, Breast Cancer. Connected to 40 entities in the SciDEX knowledge graph.
| Gene Symbol | NTRK3 |
| Full Name | Neurotrophic Receptor Tyrosine Kinase 3 |
| Chromosome | 15q25.3 |
| Protein Family | Trk family (NTRK1, NTRK2, NTRK3) |
| Protein Type | Receptor |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Molecular Weight | ~94 kDa |
| Amino Acids | 843 aa |
| Exons | 19 |
| Pathways | PI3K, MAPK |
| UniProt ID | Q15006 |
| NCBI Gene ID | 4916 |
| Ensembl ID | ENSG00000184348 |
| OMIM | 191316 |
| GeneCards | NTRK3 |
| Human Protein Atlas | NTRK3 |
| Associated Diseases | Breast Cancer, Cancer, Carcinoma, Ms |
| Known Drugs/Compounds | dasatinib |
| Interactions | EGR1, FOS, NTRK2, GAD1, CALB2, CALB1 |
| KG Connections | 119 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
NTRK3["<b>NTRK3</b>"]
Leukemia{"Leukemia"}
NTRK3 -->|"activates"| Leukemia
Als{"Als"}
NTRK3 -->|"activates"| Als
Ms{"Ms"}
NTRK3 -->|"associated with"| Ms
Cancer{"Cancer"}
NTRK3 -->|"associated with"| Cancer
Carcinoma{"Carcinoma"}
NTRK3 -->|"associated with"| Carcinoma
ALS{"ALS"}
NTRK3 -->|"activates"| ALS
CSF1R["CSF1R"]
NTRK3 -->|"contributes to"| CSF1R
PTK2B["PTK2B"]
NTRK3 -->|"contributes to"| PTK2B
ETV6["ETV6"]
NTRK3 -->|"expressed in"| ETV6
ABL1["ABL1"]
NTRK3 -->|"contributes to"| ABL1
PDGFRB["PDGFRB"]
NTRK3 -->|"contributes to"| PDGFRB
GENES["GENES"]
NTRK3 -->|"activates"| GENES
TYK2["TYK2"]
TYK2 -->|"contributes to"| NTRK3
PTK2B -->|"contributes to"| NTRK3
IL7R["IL7R"]
IL7R -->|"contributes to"| NTRK3
JAK2["JAK2"]
JAK2 -->|"contributes to"| NTRK3
PDGFRB -->|"contributes to"| NTRK3
ETV6 -->|"expressed in"| NTRK3
ABL2["ABL2"]
ABL2 -->|"contributes to"| NTRK3
ABL1 -->|"contributes to"| NTRK3
CSF1R -->|"contributes to"| NTRK3
EPOR["EPOR"]
EPOR -->|"contributes to"| NTRK3
TSLP["TSLP"]
TSLP -->|"contributes to"| NTRK3
GENES -->|"activates"| NTRK3
style NTRK3 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Leukemia | activates | disease | 0.65 |
| Als | activates | disease | 0.65 |
| Ms | associated_with | disease | 0.65 |
| Cancer | associated_with | disease | 0.65 |
| Carcinoma | associated_with | disease | 0.65 |
| ALS | activates | disease | 0.65 |
| Breast Cancer | associated_with | disease | 0.65 |
| Carcinoma | causes | disease | 0.65 |
| CSF1R | contributes_to | gene | 0.60 |
| PTK2B | contributes_to | gene | 0.60 |
| PDGFRB | contributes_to | gene | 0.60 |
| JAK2 | contributes_to | gene | 0.60 |
| TYK2 | contributes_to | gene | 0.60 |
| IL7R | contributes_to | gene | 0.60 |
| PDGFRB | activates | entity | 0.60 |
| PTK2B | activates | entity | 0.60 |
| TYK2 | activates | entity | 0.60 |
| PDGFRB | expressed_in | entity | 0.60 |
| EGR1 | activates | gene | 0.60 |
| FOS | activates | gene | 0.60 |
| NTRK2 | activates | gene | 0.60 |
| BDNF | associated_with | gene | 0.60 |
| GAD1 | activates | gene | 0.60 |
| NTF3 | associated_with | gene | 0.60 |
| CALB2 | activates | gene | 0.60 |
| CALB1 | activates | gene | 0.60 |
| PVALB | activates | gene | 0.60 |
| S100B | activates | gene | 0.60 |
| GFAP | activates | gene | 0.60 |
| MAPK1 | activates | gene | 0.60 |
| CREB1 | activates | gene | 0.60 |
| Rb | contributes_to | protein | 0.60 |
| ETV6 | expressed_in | gene | 0.60 |
| ABL1 | contributes_to | gene | 0.60 |
| GENES | activates | gene | 0.60 |
| EPOR | contributes_to | gene | 0.60 |
| CANCER | associated_with | gene | 0.60 |
| CDH1 | associated_with | gene | 0.60 |
| ETV6 | associated_with | gene | 0.60 |
| ABL2 | contributes_to | gene | 0.60 |
| TSLP | contributes_to | gene | 0.60 |
| CDH1 | causes | gene | 0.60 |
| GENES | associated_with | gene | 0.60 |
| CRLF2 | contributes_to | gene | 0.60 |
| FLT3 | contributes_to | gene | 0.60 |
| ASTROCYTES | activates | gene | 0.60 |
| Mapk | activates | pathway | 0.60 |
| Neuron | associated_with | cell_type | 0.60 |
| Astrocyte | activates | cell_type | 0.60 |
| AND | contributes_to | gene | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| TYK2 | contributes_to | gene | 0.60 |
| PTK2B | contributes_to | gene | 0.60 |
| IL7R | contributes_to | gene | 0.60 |
| JAK2 | contributes_to | gene | 0.60 |
| PDGFRB | contributes_to | gene | 0.60 |
| CSF1R | contributes_to | gene | 0.60 |
| CSF1R | activates | entity | 0.60 |
| IL7R | activates | entity | 0.60 |
| JAK2 | activates | entity | 0.60 |
| CSF1R | expressed_in | entity | 0.60 |
| JAK2 | expressed_in | entity | 0.60 |
| MAPK1 | activates | gene | 0.60 |
| CREB1 | activates | gene | 0.60 |
| GAD1 | activates | gene | 0.60 |
| BDNF | associated_with | gene | 0.60 |
| GFAP | activates | gene | 0.60 |
| NTF3 | associated_with | gene | 0.60 |
| FOS | activates | gene | 0.60 |
| PVALB | activates | gene | 0.60 |
| CALB2 | activates | gene | 0.60 |
| EGR1 | activates | gene | 0.60 |
| CALB1 | activates | gene | 0.60 |
| NTRK2 | activates | gene | 0.60 |
| S100B | activates | gene | 0.60 |
| ETV6 | expressed_in | gene | 0.60 |
| ABL2 | contributes_to | gene | 0.60 |
| ABL1 | contributes_to | gene | 0.60 |
| EPOR | contributes_to | gene | 0.60 |
| TSLP | contributes_to | gene | 0.60 |
| GENES | activates | gene | 0.60 |
| ETV6 | causes | gene | 0.60 |
| AND | contributes_to | gene | 0.60 |
| FLT3 | contributes_to | gene | 0.60 |
| AND | associated_with | gene | 0.60 |
| ASTROCYTES | activates | gene | 0.60 |
| ABL1 | activates | gene | 0.60 |
| ABL2 | activates | gene | 0.60 |
| CRLF2 | activates | gene | 0.60 |
| EPOR | activates | gene | 0.60 |
| FLT3 | activates | gene | 0.60 |
| ABL1 | expressed_in | gene | 0.60 |
| ABL2 | expressed_in | gene | 0.60 |
| EPOR | expressed_in | gene | 0.60 |
| dasatinib | targets | drug | 0.60 |
| PDGFRB | activates | gene | 0.50 |
| TYK2 | activates | gene | 0.50 |
| PDGFRB | expressed_in | gene | 0.50 |
| BDNF | interacts_with | gene | 0.50 |
| NTF3 | interacts_with | gene | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||