gene

NTRK3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about NTRK3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

119Connections
0Hypotheses
0Analyses
50Outgoing
49Incoming

Summary

NTRK3 is a gene implicated in neurodegeneration research. Key relationships include: contributes to, associated with, activates. Associated with ALS, Als, Breast Cancer. Connected to 40 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolNTRK3
Full NameNeurotrophic Receptor Tyrosine Kinase 3
Chromosome15q25.3
Protein FamilyTrk family (NTRK1, NTRK2, NTRK3)
Protein TypeReceptor
Functionis an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight~94 kDa
Amino Acids843 aa
Exons19
PathwaysPI3K, MAPK
UniProt IDQ15006
NCBI Gene ID4916
Ensembl IDENSG00000184348
OMIM191316
GeneCardsNTRK3
Human Protein AtlasNTRK3
Associated DiseasesBreast Cancer, Cancer, Carcinoma, Ms
Known Drugs/Compoundsdasatinib
InteractionsEGR1, FOS, NTRK2, GAD1, CALB2, CALB1
KG Connections119 knowledge graph edges
DatabasesGeneCardsHPASTRING
🔮 Predicted Structure: NTRK3 — AlphaFold Q15006 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

NTRK3 Gene

gene · 930 words

Growth Factor Therapeutics: Investment Landscape Analysis

investment · 4064 words

BDNF/Neurotrophin Signaling in Neurodegeneration

mechanism · 3338 words

neurotrophin-signaling-dysfunction-parkinsons

general · 2457 words

Dopaminergic VTA Neurons in Parkinson's Disease

cell · 2417 words

NT-3 Signaling Pathway in Neurodegeneration

mechanism · 2372 words

Pathway Diagram

graph TD
    NTRK3["<b>NTRK3</b>"]
    Leukemia{"Leukemia"}
    NTRK3 -->|"activates"| Leukemia
    Als{"Als"}
    NTRK3 -->|"activates"| Als
    Ms{"Ms"}
    NTRK3 -->|"associated with"| Ms
    Cancer{"Cancer"}
    NTRK3 -->|"associated with"| Cancer
    Carcinoma{"Carcinoma"}
    NTRK3 -->|"associated with"| Carcinoma
    ALS{"ALS"}
    NTRK3 -->|"activates"| ALS
    CSF1R["CSF1R"]
    NTRK3 -->|"contributes to"| CSF1R
    PTK2B["PTK2B"]
    NTRK3 -->|"contributes to"| PTK2B
    ETV6["ETV6"]
    NTRK3 -->|"expressed in"| ETV6
    ABL1["ABL1"]
    NTRK3 -->|"contributes to"| ABL1
    PDGFRB["PDGFRB"]
    NTRK3 -->|"contributes to"| PDGFRB
    GENES["GENES"]
    NTRK3 -->|"activates"| GENES
    TYK2["TYK2"]
    TYK2 -->|"contributes to"| NTRK3
    PTK2B -->|"contributes to"| NTRK3
    IL7R["IL7R"]
    IL7R -->|"contributes to"| NTRK3
    JAK2["JAK2"]
    JAK2 -->|"contributes to"| NTRK3
    PDGFRB -->|"contributes to"| NTRK3
    ETV6 -->|"expressed in"| NTRK3
    ABL2["ABL2"]
    ABL2 -->|"contributes to"| NTRK3
    ABL1 -->|"contributes to"| NTRK3
    CSF1R -->|"contributes to"| NTRK3
    EPOR["EPOR"]
    EPOR -->|"contributes to"| NTRK3
    TSLP["TSLP"]
    TSLP -->|"contributes to"| NTRK3
    GENES -->|"activates"| NTRK3
    style NTRK3 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (70)

TargetRelationTypeStr
Leukemiaactivatesdisease0.65
Alsactivatesdisease0.65
Msassociated_withdisease0.65
Cancerassociated_withdisease0.65
Carcinomaassociated_withdisease0.65

Incoming (49)

SourceRelationTypeStr
TYK2contributes_togene0.60
PTK2Bcontributes_togene0.60
IL7Rcontributes_togene0.60
JAK2contributes_togene0.60
PDGFRBcontributes_togene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found