Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about PTPN11: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| Overall Survival | biomarker_for | phenotype | 0.85 |
| oncogenic pathway activation | activates | pathway | 0.70 |
| oncogenic pathway | activates | pathway | 0.70 |
| RHEB | interacts_with | gene | 0.60 |
| autophagy pathway | participates_in | pathway | 0.60 |
| oxidative stress response | participates_in | pathway | 0.60 |
| synaptic plasticity | participates_in | pathway | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| AKT3 | interacts_with | gene | 0.60 |
| BRAF | interacts_with | gene | 0.60 |
| DYRK1A | interacts_with | gene | 0.60 |
| EGFR | interacts_with | gene | 0.60 |
| FGFR1 | interacts_with | gene | 0.60 |
| MTOR | interacts_with | gene | 0.60 |
| NF1 | interacts_with | gene | 0.60 |
| NRAS | interacts_with | gene | 0.60 |
| PIK3CA | interacts_with | gene | 0.60 |
| PTEN | interacts_with | gene | 0.60 |
| BRCA | associated_with | gene | 0.60 |
| HCRTR1 | interacts_with | gene | 0.60 |
| HCRTR1 | activates | gene | 0.60 |
| HCRTR2 | activates | gene | 0.60 |
| NPY4R | activates | gene | 0.60 |
| CD33 | interacts_with | gene | 0.60 |
| KRAS | interacts_with | gene | 0.60 |
| MEK | activates | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||