RHEB

Understanding Entity Pages

This page aggregates everything SciDEX knows about RHEB: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

RHEB is a gene implicated in neurodegeneration research. Key relationships include: interacts with, activates, inhibits. Associated with ALS, Aging, Als. Connected to 186 entities in the SciDEX knowledge graph.

View on Wiki →

flowchart TD
    RHEB["RHEB<br/>GTPase"]
    mTOR["mTOR<br/>Kinase"]
    RPTOR["RPTOR<br/>mTOR Component"]
    
    TSC1_TSC2["TSC1/TSC2<br/>Complex"]
    LRRK2["LRRK2<br/>Kinase"]
    
    ATG16L1["ATG16L1<br/>Autophagy"]
    BECN1["BECN1<br/>Autophagy Initiator"]
    LC3["LC3<br/>Autophagosome<br/>Marker"]
    RB1CC1["RB1CC1/FIP200<br/>Autophagy<br/>Regulator"]
    GABARAP["GABARAP<br/>Autophagy<br/>Modifier"]
    
    EIF2AK3["EIF2AK3/PERK<br/>ER Stress<br/>Kinase"]
    ERN1["ERN1/IRE1<br/>ER Stress<br/>Sensor"]
    EIF2A["EIF2A<br/>Translation<br/>Factor"]
    
    STAT3["STAT3<br/>Transcription<br/>Factor"]
    IFNG["IFNG<br/>Inflammatory<br/>Cytokine"]
    
    ALS["ALS<br/>Motor Neuron<br/>Disease"]
    MS["MS<br/>Autoimmune<br/>Disease"]
    
    RHEB --|"activates"|--> mTOR
    mTOR --|"complexes_with"|--> RPTOR
    TSC1_TSC2 --|"inhibits"|--> RHEB
    
    mTOR --|"inhibits"|--> ATG16L1
    mTOR --|"inhibits"|--> BECN1
    BECN1 --|"initiates"|--> LC3
    ATG16L1 --|"regulates"|--> LC3
    RB1CC1 --|"facilitates"|--> BECN1
    LC3 --|"conjugates_with"|--> GABARAP
    
    LRRK2 --|"modulates"|--> RHEB
    LRRK2 --|"affects"|--> ATG16L1
    
    EIF2AK3 --|"phosphorylates"|--> EIF2A
    ERN1 --|"coordinates_with"|--> EIF2AK3
    mTOR --|"regulates"|--> EIF2A
    
    STAT3 --|"responds_to"|--> IFNG
    RHEB --|"modulates"|--> STAT3
    
    RHEB --|"contributes_to"|--> ALS
    RHEB --|"therapeutic_target"|--> MS
    
    style RHEB fill:#006494
    style mTOR fill:#ef5350
    style ATG16L1 fill:#1b5e20
    style BECN1 fill:#1b5e20
    style LC3 fill:#1b5e20
    style EIF2AK3 fill:#ef5350
    style ERN1 fill:#ef5350
    style LRRK2 fill:#4a1a6b
    style STAT3 fill:#4a1a6b
    style ALS fill:#5d4400
    style MS fill:#5d4400