gene

S100A6

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about S100A6: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

40Connections

0Hypotheses

0Analyses

29Outgoing

11Incoming

Summary

Comprehensive guide to S100A6 (S100 Calcium Binding Protein A6, also known as Calcyclin), a calcium-binding protein of the S100 family implicated in cell proliferation, cytoskeletal dynamics, and neurodegenerative diseases including Alzheimer's and Parkin

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🧬 Gene Info

Gene Symbol	S100A6
Aliases	CALCYCLIN, S100A6, CACY, SIAS
Chromosome	1q21.3
Function	is a member of the S100 family of small calcium-binding proteins.
Primary Expression	a tissue-specific manner, with high expression in the brain, particularly in neurons and glial cells
Molecular Weight	10.2 kDa
Amino Acids	91 aa
Exons	3
Pathways	Dna Repair, Immune Response
UniProt ID	P06703
NCBI Gene ID	6277
Ensembl ID	ENSG00000197646
GeneCards	S100A6
Human Protein Atlas	S100A6
Uniprot ID	P06703
Associated Diseases	neurodegeneration
Interactions	Proteins, APOPTOSIS
KG Connections	40 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: S100A6 — AlphaFold P06703 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (4)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    S100A6["<b>S100A6</b>"]
    Als{"Als"}
    S100A6 -->|"expressed in"| Als
    Cancer{"Cancer"}
    S100A6 -->|"expressed in"| Cancer
    AKT["AKT"]
    S100A6 -->|"expressed in"| AKT
    CANCER["CANCER"]
    S100A6 -->|"expressed in"| CANCER
    PRDX5["PRDX5"]
    S100A6 -->|"associated with"| PRDX5
    CTSD["CTSD"]
    S100A6 -->|"associated with"| CTSD
    Akt(["Akt"])
    S100A6 -->|"expressed in"| Akt
    neurodegeneration["neurodegeneration"]
    S100A6 -->|"implicated in"| neurodegeneration
    CALR["CALR"]
    CALR -->|"associated with"| S100A6
    style S100A6 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (29)

Target	Relation	Type	Str
Als	expressed_in	disease	0.65
Cancer	expressed_in	disease	0.65
Tumor	treats	disease	0.65
Infection	regulates	disease	0.65
Als	regulates	disease	0.65
Als	therapeutic_target	disease	0.65
Cancer	therapeutic_target	disease	0.65
Cancer	regulates	disease	0.65
ALS	regulates	disease	0.65
Carcinoma	regulates	disease	0.65
AKT	expressed_in	gene	0.60
PRDX5	associated_with	gene	0.60
CTSD	associated_with	gene	0.60
CXCL2	treats	gene	0.60
CD4	regulates	gene	0.60
MYC	regulates	gene	0.60
H2AX	therapeutic_target	gene	0.60
CANCER	expressed_in	gene	0.60
Akt	expressed_in	pathway	0.60
Apoptosis	inhibits	pathway	0.60
Immune Response	regulates	pathway	0.60
DNA	therapeutic_target	gene	0.60
T Cell	therapeutic_target	cell_type	0.60
Dna Repair	regulates	pathway	0.60
Dna Repair	therapeutic_target	pathway	0.60
App	therapeutic_target	protein	0.60
apoptosis pathway	participates_in	pathway	0.60
T Cell	expressed_in	cell_type	0.55
Proteins	interacts_with	protein	0.50

Incoming (11)

Source	Relation	Type	Str
CALR	associated_with	gene	0.60
TNF	treats	gene	0.60
H2AX	therapeutic_target	gene	0.60
CD4	regulates	gene	0.60
APOPTOSIS	inhibits	gene	0.60
CYTOKINES	treats	gene	0.60
TNF-Α	treats	gene	0.60
PROINFLAMMATORY CYTOKINES	treats	gene	0.60
CANCER	regulates	gene	0.60
AND	regulates	gene	0.60
DNA	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found