Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about SPG11: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
SPG11 is a gene implicated in neurodegeneration research. Key relationships include: associated with, implicated in, inhibits. Associated with Inflammation, Neurodegeneration, Neuroinflammation. Connected to 13 entities in the SciDEX knowledge graph.
| Gene Symbol | SPG11 |
| Aliases | Page for SPG11 Gene |
| Chromosome | 10p14 |
| Function | is a large cytoplasmic protein encoded by the SPG11 gene located on chromosome 15q21. |
| Primary Expression | Predominantly neuronal |
| Molecular Weight | 250 kDa |
| Amino Acids | 163 aa |
| Exons | 40 |
| UniProt ID | Q96MC7 |
| NCBI Gene ID | 80208 |
| GeneCards | SPG11 |
| Human Protein Atlas | SPG11 |
| Model | Applications |
| Mouse models | Phenotype studies, drug testing |
| Zebrafish | Developmental studies |
| Associated Diseases | Inflammation, Neuroinflammation, neurodegeneration |
| Interactions | MICROGLIA, NEURODEGENERATION |
| KG Connections | 30 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
SPG11["<b>SPG11</b>"]
Neuroinflammation{"Neuroinflammation"}
SPG11 -->|"associated with"| Neuroinflammation
Neurodegeneration{"Neurodegeneration"}
SPG11 -->|"inhibits"| Neurodegeneration
Inflammation{"Inflammation"}
SPG11 -->|"associated with"| Inflammation
NEUROINFLAMMATION["NEUROINFLAMMATION"]
SPG11 -->|"associated with"| NEUROINFLAMMATION
Innate_Immunity(["Innate Immunity"])
SPG11 -->|"associated with"| Innate_Immunity
neurodegeneration["neurodegeneration"]
SPG11 -->|"implicated in"| neurodegeneration
MICROGLIA["MICROGLIA"]
MICROGLIA -->|"activates"| SPG11
NEURODEGENERATIVE_DISEASES["NEURODEGENERATIVE DISEASES"]
NEURODEGENERATIVE_DISEASES -->|"associated with"| SPG11
NEURODEGENERATION["NEURODEGENERATION"]
NEURODEGENERATION -->|"inhibits"| SPG11
style SPG11 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Neuroinflammation | associated_with | disease | 0.65 |
| Neurodegeneration | inhibits | disease | 0.65 |
| Inflammation | associated_with | disease | 0.65 |
| SPG15 | associated_with | gene | 0.60 |
| TAF15 | associated_with | gene | 0.60 |
| TARDBP | associated_with | gene | 0.60 |
| VAPB | associated_with | gene | 0.60 |
| VCP | associated_with | gene | 0.60 |
| neurodegeneration | associated_with | disease | 0.60 |
| NEUROINFLAMMATION | associated_with | gene | 0.60 |
| Innate Immunity | associated_with | pathway | 0.60 |
| Autophagy | implicated_in | pathway | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| ALS2 | associated_with | gene | 0.60 |
| ANG | associated_with | gene | 0.60 |
| DAO | associated_with | gene | 0.60 |
| DCTN1 | associated_with | gene | 0.60 |
| FIG4 | associated_with | gene | 0.60 |
| FUS | associated_with | gene | 0.60 |
| NEFH | associated_with | gene | 0.60 |
| OPTN | associated_with | gene | 0.60 |
| SETX | associated_with | gene | 0.60 |
| GBA1 | associated_with | gene | 0.60 |
| SMPD1 | associated_with | gene | 0.60 |
| SNCA | associated_with | gene | 0.60 |
| MICROGLIA | activates | gene | 0.60 |
| NEURODEGENERATIVE DISEASES | associated_with | gene | 0.60 |
| NEURODEGENERATION | inhibits | gene | 0.60 |
| LYSOSOME | implicated_in | gene | 0.60 |
| AUTOPHAGY | implicated_in | gene | 0.60 |
| ALS | associated_with | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||