gene

VAPB

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about VAPB: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

83Connections
0Hypotheses
0Analyses
50Outgoing
33Incoming

Summary

VAPB is a gene implicated in neurodegeneration research. Key relationships include: associated with, interacts with, implicated in. Associated with Als, Alzheimer, Amyotrophic Lateral Sclerosis. Connected to 18 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolVAPB
Full NameVesicle-Associated Membrane Protein-Associated Protein B
AliasesVAMP-Associated Protein B
Chromosome20q13.33
Functionis an important component in the neurobiology of neurodegenerative diseases.
Molecular Weight33 kDa
Amino Acids243 aa
PathwaysImmune Response
UniProt IDO95295
NCBI Gene ID9217
Ensembl IDENSG00000124194
OMIM608627
GeneCardsVAPB
Human Protein AtlasVAPB
Protein NameVAP-B
Associated DiseasesAging, Als, Amyotrophic Lateral Sclerosis, Cardiovascular, Dementia, Ms
InteractionsVCP, NPC1, FUS, OPTN, UBQLN2, AND
KG Connections83 knowledge graph edges
DatabasesGeneCardsHPASTRING
🔮 Predicted Structure: VAPB — AlphaFold O95295 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

VAPB (VAMP-Associated Protein B)

gene · 723 words

Mitochondria-Lysosome Contact Site Dysfunction in Parkinson's Disease

mechanism · 3314 words

Mitochondria-Lysosome Contact Site (MLCS) Dysfunction Hypothesis in Parkinson's Disease

hypothesis · 2796 words

Mitochondrial Fission in Neurodegeneration

mechanism · 2732 words

Mitochondria-Lysosome Contact Sites in Parkinson's Disease

mechanism · 2730 words

MLCS Quantification in Parkinson's Disease

experiment · 2507 words

Pathway Diagram

graph TD
    VAPB["<b>VAPB</b>"]
    Amyotrophic_Lateral_Sclerosis{"Amyotrophic Lateral Sclerosis"}
    VAPB -->|"interacts with"| Amyotrophic_Lateral_Sclerosis
    Dementia{"Dementia"}
    VAPB -->|"interacts with"| Dementia
    Alzheimer{"Alzheimer"}
    VAPB -->|"interacts with"| Alzheimer
    Als{"Als"}
    VAPB -->|"interacts with"| Als
    Parkinson{"Parkinson"}
    VAPB -->|"interacts with"| Parkinson
    Ms{"Ms"}
    VAPB -->|"interacts with"| Ms
    Neurodegeneration{"Neurodegeneration"}
    VAPB -->|"associated with"| Neurodegeneration
    VAPB -->|"associated with"| Amyotrophic_Lateral_Sclerosis
    VAPB -->|"associated with"| Dementia
    VAPB -->|"associated with"| Als
    VAPB -->|"associated with"| Ms
    CHMP2B["CHMP2B"]
    VAPB -->|"associated with"| CHMP2B
    C9ORF72["C9ORF72"]
    C9ORF72 -->|"associated with"| VAPB
    GENES["GENES"]
    GENES -->|"associated with"| VAPB
    style VAPB fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (50)

TargetRelationTypeStr
Amyotrophic Lateral Sclerosisinteracts_withdisease0.65
Dementiainteracts_withdisease0.65
Alzheimerinteracts_withdisease0.65
Alsinteracts_withdisease0.65
Parkinsoninteracts_withdisease0.65

Incoming (33)

SourceRelationTypeStr
C9ORF72associated_withgene0.60
NPC1activatesgene0.60
CGASregulatesgene0.60
OVERVIEWtherapeutic_targetgene0.60
ALS2associated_withgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found