Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about STX1A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | STX1A |
| Aliases | Page for STX1A Gene |
| Chromosome | 7q11.23 |
| Function | Synaptic vesicle fusion, SNARE complex formation |
| Primary Expression | the central nervous system and has been implicated in various neurological disorders |
| Molecular Weight | 35 kDa |
| Amino Acids | 288 aa |
| GeneCards | STX1A |
| Human Protein Atlas | STX1A |
| Protein | Syntaxin-1A |
| Related Diseases | Alzheimer's Disease, Parkinson's Disease, Schizophrenia |
| Associated Diseases | Alzheimer's disease, epilepsy, autism, schizophrenia |
| Interactions | DEPRESSION |
| KG Connections | 16 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
STX1A["STX1A"]
STX1A -->|"inhibits"| Depression["Depression"]
STX1A -->|"inhibits"| Neuroinflammation["Neuroinflammation"]
STX1A -->|"expressed in"| NLRP3["NLRP3"]
STX1A -->|"expressed in"| BDNF["BDNF"]
STX1A -->|"expressed in"| VAMP2["VAMP2"]
STX1A -->|"expressed in"| PSD95["PSD95"]
STX1A -->|"expressed in"| BCL_2["BCL-2"]
STX1A -->|"expressed in"| BAX["BAX"]
DEPRESSION["DEPRESSION"] -->|"inhibits"| STX1A| Target | Relation | Type | Str |
|---|---|---|---|
| Depression | inhibits | disease | 0.65 |
| Neuroinflammation | inhibits | disease | 0.65 |
| NLRP3 | expressed_in | gene | 0.60 |
| BDNF | expressed_in | gene | 0.60 |
| VAMP2 | expressed_in | gene | 0.60 |
| PSD95 | expressed_in | gene | 0.60 |
| BAX | expressed_in | gene | 0.60 |
| SNAP25 | expressed_in | gene | 0.60 |
| GAP43 | expressed_in | gene | 0.60 |
| TRKB | expressed_in | gene | 0.60 |
| BCL-2 | expressed_in | gene | 0.60 |
| Neuron | inhibits | cell_type | 0.60 |
| STX4 | regulates | gene | 0.55 |
| Source | Relation | Type | Str |
|---|---|---|---|
| DEPRESSION | inhibits | gene | 0.60 |
| STX17 | regulates | gene | 0.55 |
| SNARE | regulates | gene | 0.55 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||