gene

VAMP2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about VAMP2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

79Connections

0Hypotheses

3Analyses

35Outgoing

44Incoming

0Experiments

5Debates

Summary

VAMP2 is a gene implicated in neurodegeneration research. Key relationships include: interacts with, regulates, co discussed. Associated with Aging, Als, Dementia. Connected to 18 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	VAMP2
Aliases	Page for VAMP2 Gene, Synaptobrevin-2
Chromosome	17p13.1
Protein Type	Protein
Function	Vesicle Docking: VAMP2 on vesicles pairs with syntaxin-1A on plasma membrane
Molecular Weight	12.6 kDa
Amino Acids	116 aa
Exons	5
UniProt ID	P60880
GeneCards	VAMP2
Human Protein Atlas	VAMP2
N-terminal region (residues 1-28)	A proline-rich, highly flexible segment that lacks secondary structure. This region contains the site for phosphorylation by casein kinase 2, which modulates VAMP2 function.
SNARE motif (residues 29-60)	The central region that forms the core of the SNARE complex. This alpha-helical segment undergoes conformational changes during SNARE assembly.
Transmembrane domain (residues 76-94)	A single-pass transmembrane anchor that tethers VAMP2 to synaptic vesicles. This region consists of a helical transmembrane segment near the C-terminus.
C-terminal region (residues 95-116)	The extreme C-terminus contributes to membrane association and may participate in interactions with other SNARE proteins.
Associated Diseases	Alzheimer's disease, Parkinson's disease
Interactions	AGING, ALPHA-SYNUCLEIN, AMYLOID, AND, APOE, APOE3
KG Connections	79 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: VAMP2 — AlphaFold P60880 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (5)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    VAMP2["VAMP2"]
    Dementia{"Dementia"}
    VAMP2 -->|"regulates"| Dementia
    Parkinson{"Parkinson"}
    VAMP2 -->|"regulates"| Parkinson
    Complement(["Complement"])
    VAMP2 -->|"interacts with"| Complement
    neurodegeneration["neurodegeneration"]
    VAMP2 -->|"implicated in"| neurodegeneration
    PARKINSON_S_DISEASE["PARKINSON'S DISEASE"]
    PARKINSON_S_DISEASE -->|"regulates"| VAMP2
    APOE3["APOE3"]
    APOE3 -->|"interacts with"| VAMP2
    NEURODEGENERATIVE_DISEASES["NEURODEGENERATIVE DISEASES"]
    NEURODEGENERATIVE_DISEASES -->|"interacts with"| VAMP2
    APOE4["APOE4"]
    APOE4 -->|"interacts with"| VAMP2
    APOE["APOE"]
    APOE -->|"interacts with"| VAMP2
    style VAMP2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (35)

Target	Relation	Type	Str
tau exocytosis	mediates	process	0.70
trans-synaptic tau transfer	prevents	mechanism	0.70
synaptic function	inhibits	process	0.70
Neuroinflammation	inhibits	disease	0.65
Depression	inhibits	disease	0.65
Dementia	regulates	disease	0.65
Parkinson	regulates	disease	0.65
Schizophrenia	inhibits	disease	0.65
Aging	interacts_with	disease	0.65
Als	interacts_with	disease	0.65
Parkinson	interacts_with	disease	0.65
Neurodegeneration	interacts_with	disease	0.65
NEURODEGENERATION	interacts_with	gene	0.60
Α-Synuclein	associated_with	protein	0.60
ALPHA-SYNUCLEIN	interacts_with	gene	0.60
Chaperone	interacts_with	pathway	0.60
PARKINSON	interacts_with	gene	0.60
TRKB	expressed_in	gene	0.60
PSD95	expressed_in	gene	0.60
autophagy pathway	participates_in	pathway	0.60
BCL-2	expressed_in	gene	0.60
BAX	expressed_in	gene	0.60
SNAP25	expressed_in	gene	0.60
GAP43	expressed_in	gene	0.60
Synaptic Transmission	interacts_with	pathway	0.60
Neuron	inhibits	cell_type	0.60
VGF	regulates	gene	0.60
Complement	interacts_with	pathway	0.60
Cortex	expressed_in	brain_region	0.55
Neuron	expressed_in	cell_type	0.55
SNAP-25	activates	protein	0.50
SYNTAXIN-1	activates	protein	0.50
Cortex	activates	brain_region	0.50
CEREBRAL CORTEX	activates	concept	0.50
SNARE	activates	protein	0.50

Incoming (44)

Source	Relation	Type	Str
ATG7	regulates	gene	0.70
GFAP	regulates	gene	0.70
GRIN2B	associated_with	gene	0.70
IBA1	regulates	gene	0.70
PSEN1	associated_with	gene	0.70
SNAP25	associated_with	gene	0.70
SQSTM1	associated_with	gene	0.70
SYN1	associated_with	gene	0.70
SYT1	associated_with	gene	0.70
AIF1	regulates	gene	0.70
APP	regulates	gene	0.70
AND	activates	gene	0.60
APOE	interacts_with	gene	0.60
STX1A	expressed_in	gene	0.60
NLRP3	expressed_in	gene	0.60
BDNF	expressed_in	gene	0.60
NEURODEGENERATION	interacts_with	gene	0.60
ALPHA-SYNUCLEIN	interacts_with	gene	0.60
NEURON	inhibits	gene	0.60
CORTEX	interacts_with	brain_region	0.60
APOE4	interacts_with	gene	0.60
APOE3	interacts_with	gene	0.60
NEURODEGENERATIVE DISEASES	interacts_with	gene	0.60
AMYLOID	interacts_with	gene	0.60
NEURON	co_discussed	cell_type	0.60
SNARE	activates	gene	0.60
BDNF	causes	gene	0.60
ATG5	regulates	gene	0.60
NEURON	expresses	cell_type	0.60
NEURONS	activates	cell_type	0.60
AD	regulates	gene	0.60
AUTOPHAGY	regulates	pathway	0.60
AΒ	regulates	gene	0.60
NEURON	activates	cell_type	0.60
DEPRESSION	inhibits	gene	0.60
PARKINSON'S DISEASE	regulates	gene	0.60
AGING	interacts_with	gene	0.60
SNAP25	interacts_with	gene	0.55
SNARE	interacts_with	gene	0.55
BDNF	co_discussed	gene	0.45
GAP43	co_discussed	gene	0.40
TAU	co_discussed	gene	0.40
SNAP25	co_discussed	gene	0.40
PSD95	co_discussed	gene	0.40

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (3)

Scientific analyses that reference this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (5)

Multi-agent debates referencing this entity

Related Research

Hypotheses and analyses mentioning VAMP2 in their description or question text

No additional research found

VAMP2

Understanding Entity Pages

Summary

Wiki Pages (5)

VAMP2 Gene - Synaptobrevin-2

VAMP2 Protein

SYNAPTOBREVIN-2 Protein (VAMP2)

VAMP2 — Synaptobrevin-2

VAMP2 Protein

Pathway Diagram

Outgoing (35)

Incoming (44)

Targeting Hypotheses (0)

Mentioning Analyses (3)

What is the therapeutic window between tau propagation inhibition and essential

Trans-synaptic tau spreading and propagation mechanisms in AD

Tau propagation mechanisms and therapeutic interception points

Experiments (0)

Related Papers (0)

Debates (5)

Debate: Enhancing Microglial Phagocytosis of Extracellular Tau via TREM2 Activat

Tau pathology spreads through synaptically connected brain regions in Alzheimer

The debate highlighted that most promising targets (VAMP2, ESCRT, fascin-1) are

Investigate prion-like spreading of tau pathology through connected brain region

Tau propagation mechanisms and therapeutic interception points

Related Research