gene

VAMP2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about VAMP2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

55Connections

0Hypotheses

2Analyses

32Outgoing

23Incoming

Summary

VAMP2 is a gene implicated in neurodegeneration research. Key relationships include: interacts with, regulates, co discussed. Associated with Aging, Als, Dementia. Connected to 18 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	VAMP2
Full Name	VAMP2 - Synaptobrevin-2
Aliases	Page for VAMP2 Gene, Synaptobrevin-2
Chromosome	17p13.1
Protein Type	Protein
Function	Vesicle Docking: VAMP2 on vesicles pairs with syntaxin-1A on plasma membrane
Molecular Weight	12.6 kDa
Amino Acids	116 aa
Exons	5
UniProt ID	P60880
NCBI Gene ID	Search NCBI
GeneCards	VAMP2
Human Protein Atlas	VAMP2
Associated Diseases	Alzheimer's disease, Parkinson's disease
Interactions	NEURODEGENERATION, ALPHA-SYNUCLEIN, SNARE, SNAP-25, SYNTAXIN-1, PARKINSON
KG Connections	55 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: VAMP2 — AlphaFold P60880 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    VAMP2["<b>VAMP2</b>"]
    Dementia{"Dementia"}
    VAMP2 -->|"regulates"| Dementia
    Parkinson{"Parkinson"}
    VAMP2 -->|"regulates"| Parkinson
    Complement(["Complement"])
    VAMP2 -->|"interacts with"| Complement
    neurodegeneration["neurodegeneration"]
    VAMP2 -->|"implicated in"| neurodegeneration
    PARKINSON_S_DISEASE["PARKINSON'S DISEASE"]
    PARKINSON_S_DISEASE -->|"regulates"| VAMP2
    APOE3["APOE3"]
    APOE3 -->|"interacts with"| VAMP2
    NEURODEGENERATIVE_DISEASES["NEURODEGENERATIVE DISEASES"]
    NEURODEGENERATIVE_DISEASES -->|"interacts with"| VAMP2
    APOE4["APOE4"]
    APOE4 -->|"interacts with"| VAMP2
    APOE["APOE"]
    APOE -->|"interacts with"| VAMP2
    style VAMP2 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (32)

Target	Relation	Type	Str
Dementia	regulates	disease	0.65
Parkinson	regulates	disease	0.65
Aging	interacts_with	disease	0.65
Als	interacts_with	disease	0.65
Neurodegeneration	interacts_with	disease	0.65
Schizophrenia	inhibits	disease	0.65
Depression	inhibits	disease	0.65
Neuroinflammation	inhibits	disease	0.65
Parkinson	interacts_with	disease	0.65
PSD95	expressed_in	gene	0.60
BAX	expressed_in	gene	0.60
SNAP25	expressed_in	gene	0.60
GAP43	expressed_in	gene	0.60
TRKB	expressed_in	gene	0.60
VGF	regulates	gene	0.60
Complement	interacts_with	pathway	0.60
NEURODEGENERATION	interacts_with	gene	0.60
ALPHA-SYNUCLEIN	interacts_with	gene	0.60
Chaperone	interacts_with	pathway	0.60
Synaptic Transmission	interacts_with	pathway	0.60
Neuron	inhibits	cell_type	0.60
BCL-2	expressed_in	gene	0.60
PARKINSON	interacts_with	gene	0.60
Α-Synuclein	associated_with	protein	0.60
autophagy pathway	participates_in	pathway	0.60
Cortex	expressed_in	brain_region	0.55
Neuron	expressed_in	cell_type	0.55
SNARE	activates	protein	0.50
SNAP-25	activates	protein	0.50
SYNTAXIN-1	activates	protein	0.50
Cortex	activates	brain_region	0.50
CEREBRAL CORTEX	activates	concept	0.50

Incoming (23)

Source	Relation	Type	Str
APOE4	interacts_with	gene	0.60
APOE	interacts_with	gene	0.60
STX1A	expressed_in	gene	0.60
NLRP3	expressed_in	gene	0.60
BDNF	expressed_in	gene	0.60
ATG5	regulates	gene	0.60
PARKINSON'S DISEASE	regulates	gene	0.60
APOE3	interacts_with	gene	0.60
NEURODEGENERATIVE DISEASES	interacts_with	gene	0.60
AGING	interacts_with	gene	0.60
AND	interacts_with	gene	0.60
AND	activates	gene	0.60
NEURODEGENERATION	interacts_with	gene	0.60
ALPHA-SYNUCLEIN	interacts_with	gene	0.60
DEPRESSION	inhibits	gene	0.60
NEURON	inhibits	gene	0.60
AMYLOID	interacts_with	gene	0.60
CORTEX	interacts_with	brain_region	0.60
SNARE	activates	gene	0.60
SNAP25	interacts_with	gene	0.55
SNARE	interacts_with	gene	0.55
SNAP25	co_discussed	gene	0.40
TAU	co_discussed	gene	0.40

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (2)

Scientific analyses that reference this entity

What is the therapeutic window between tau propagation inhibition and essential

neurodegeneration | 2026-04-06 | 0 hypotheses

Tau propagation mechanisms and therapeutic interception points

neurodegeneration | 2026-04-04 | 7 hypotheses Top: 0.487

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

VAMP2

Understanding Entity Pages

Summary

Wiki Pages (21)

VAMP2 Gene - Synaptobrevin-2

CNTN6 — Contactin 6

Synaptic Vesicle Trafficking in Parkinson's Disease

CNTN3 — Contactin 3

Cerebrospinal Fluid (CSF) Biomarkers Overview

SLC30A3 — Solute Carrier Family 30 Member 3 (ZnT3)

Synaptic Vesicle Cycle

Synaptic Vesicle Trafficking

Cerebellar Parallel Fibers

GSK-3β

Extracellular Vesicle-Mediated Synuclein Propagation Hypothesis in Parkinson's Disease

Synaptic Loss and Dysfunction Pathway

Synaptic Dysfunction in Parkinson's Disease

Retromer Stabilizers for Neurodegeneration

TMEM163 — Transmembrane Protein 163

syt10

Mitochondria-Lysosome Contact Site (MLCS) Dysfunction Hypothesis in Parkinson's Disease

Membrane Trafficking Pathway Dysfunction in Neurodegeneration

SYT9 Gene

Synaptic Dysfunction Comparison in Neurodegenerative Diseases

STX2 — Syntaxin 2