Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about TNF receptor: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| necroptosis | activates | pathway | 0.90 |
| NF-kB signaling | activates | pathway | 0.80 |
| microglia | expressed_in | cell_type | 0.70 |
| cerebral cortex | expressed_in | brain_region | 0.60 |
| BDNF-TrkB signaling | activates | pathway | 0.60 |
| cortex | expressed_in | brain_region | 0.60 |
| hippocampus | expressed_in | brain_region | 0.60 |
| astrocytes | expressed_in | cell_type | 0.60 |
| neurons | expressed_in | cell_type | 0.60 |
| apoptosis pathway | activates | pathway | 0.60 |
| endothelial cells | expressed_in | cell_type | 0.60 |
| T cells | expressed_in | cell_type | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| TNF | activates | gene | 0.90 |
| TNF | interacts_with | gene | 0.80 |
| TNF | inhibits | gene | 0.80 |
| TNF | expressed_in | gene | 0.70 |
| RIPK3 | regulates | gene | 0.70 |
| RIPK1 | activates | gene | 0.70 |
| IBA1 | activates | gene | 0.60 |
| neuroinflammation | involves | disease | 0.60 |
| IBA1 | interacts_with | gene | 0.60 |
| TNF | causes | gene | 0.60 |
| anxiety | involves | disease | 0.60 |
| TNF | implicated_in | gene | 0.60 |
| RIPK1 | expressed_in | gene | 0.60 |
| RIPK1 | suppresses | gene | 0.60 |
| TNF | suppresses | gene | 0.60 |
| RIPK1 | regulates | gene | 0.60 |
| MLKL | regulates | gene | 0.60 |
| RIPK1 | implicated_in | gene | 0.60 |
| RIPK3 | implicated_in | gene | 0.60 |
| MLKL | implicated_in | gene | 0.60 |
| BDNF | associated_with | gene | 0.60 |
| RIPK1 | inhibits | gene | 0.60 |
| RIPK3 | activates | gene | 0.60 |
| RIPK1 | interacts_with | gene | 0.60 |
| RIPK3 | interacts_with | gene | 0.60 |
| STAT1 | activates | gene | 0.60 |
| STAT1 | regulates | gene | 0.60 |
| TNF | regulates | gene | 0.60 |
| TNF | biomarker_for | gene | 0.60 |
| CCL2 | associated_with | gene | 0.60 |
| IFN | inhibits | gene | 0.60 |
| IFN | biomarker_for | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||