concept

BDNF-TRKB SIGNALING

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about BDNF-TRKB SIGNALING: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

40Connections

2Hypotheses

1Analyses

13Outgoing

27Incoming

0Experiments

1Debates

No summary available yet.

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💡 Concept Info

Name	BDNF-TRKB SIGNALING

Pathway Diagram

graph TD
    BDNF_TRKB_SIGNALING[BDNF-TRKB SIGNALING]
    BDNF_TRKB_SIGNALING -->|active_in| hippocampus[hippocampus]
    BDNF_TRKB_SIGNALING -->|active_in| neurons[neurons]
    BDNF_TRKB_SIGNALING -->|crosstalk_with| PI3K_AKT_mTOR_signaling[PI3K-AKT-mTOR signaling]
    BDNF_TRKB_SIGNALING -->|crosstalk_with| unfolded_protein_response[unfolded protein response]
    BDNF_TRKB_SIGNALING -->|active_in| prefrontal_cortex[prefrontal cortex]
    BDNF_TRKB_SIGNALING -->|crosstalk_with| CREB_signaling[CREB signaling]
    BDNF_TRKB_SIGNALING -->|crosstalk_with| synaptic_plasticity[synaptic plasticity]
    BDNF_TRKB_SIGNALING -->|active_in| microglia[microglia]
    BDNF_TRKB_SIGNALING -->|active_in| astrocytes[astrocytes]
    BDNF_TRKB_SIGNALING -->|active_in| cortex[cortex]
    BDNF[BDNF] -->|participates in| BDNF_TRKB_SIGNALING
    CREB[CREB] -->|participates in| BDNF_TRKB_SIGNALING
    Alzheimer_s_disease[Alzheimer's disease] -->|involves| BDNF_TRKB_SIGNALING
    PI3K[PI3K] -->|participates in| BDNF_TRKB_SIGNALING
    ERK[ERK] -->|participates in| BDNF_TRKB_SIGNALING
    endosome[endosome] -->|involved_in| BDNF_TRKB_SIGNALING
    depression[depression] -->|involves| BDNF_TRKB_SIGNALING
    anxiety[anxiety] -->|involves| BDNF_TRKB_SIGNALING
    neuroinflammation[neuroinflammation] -->|involves| BDNF_TRKB_SIGNALING
    GFAP[GFAP] -->|participates in| BDNF_TRKB_SIGNALING

Outgoing (13)

Target	Relation	Type	Str
neurons	active_in	cell_type	0.90
hippocampus	active_in	brain_region	0.90
MPTP toxicity	decreases_risk	phenotype	0.70
PI3K-AKT-mTOR signaling	crosstalk_with	pathway	0.70
unfolded protein response	crosstalk_with	pathway	0.70
synaptic plasticity	crosstalk_with	pathway	0.60
prefrontal cortex	active_in	brain_region	0.60
microglia	active_in	cell_type	0.60
astrocytes	active_in	cell_type	0.60
cortex	active_in	brain_region	0.60
NF-kB signaling	crosstalk_with	pathway	0.60
neural stem cells	active_in	cell_type	0.60
CREB signaling	crosstalk_with	pathway	0.60

Incoming (27)

Source	Relation	Type	Str
BDNF	participates_in	gene	0.90
Alzheimer's disease	involves	disease	0.90
CREB	participates_in	gene	0.90
ERK	participates_in	gene	0.80
PI3K	participates_in	gene	0.80
depression	involves	disease	0.70
endosome	involved_in	organelle	0.70
neuroinflammation	involves	disease	0.70
GFAP	participates_in	gene	0.70
anxiety	involves	disease	0.70
axon	involved_in	organelle	0.60
NGF	participates_in	gene	0.60
stroke	involves	disease	0.60
ERK1	participates_in	gene	0.60
CCL2	participates_in	gene	0.60
aging	involves	disease	0.60
JNK	participates_in	gene	0.60
GABA	participates_in	gene	0.60
AKT	participates_in	gene	0.60
AMPA receptor	activates	receptor	0.60
TNF receptor	activates	receptor	0.60
BIN1	participates_in	gene	0.60
TRKB	participates_in	gene	0.60
APP	participates_in	gene	0.60
obesity	involves	disease	0.60
IBA1	participates_in	gene	0.60
TNF	participates_in	gene	0.60

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Activity-Dependent Synaptic Tagging via CREB-BDNF-TrkB Signa	0.646	synaptic-biology	What determines the selectivity of compl
5-HT2A/C Silencing Enables Sustained BDNF-TrkB Signaling for	0.545	-	What is the minimum effective dose of tr

Mentioning Analyses (1)

Scientific analyses that reference this entity

Why does PGC-1α overexpression paradoxically increase MPTP toxicity despite enha

neurodegeneration | 2026-04-13 | 0 hypotheses

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

PGC-1α is known to enhance mitochondrial function and antioxidant responses, yet

closed · Rounds: 4 · Score: 0.70 · 2026-04-16

Related Research

Hypotheses and analyses mentioning BDNF-TRKB SIGNALING in their description or question text

No additional research found