Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about BDNF-TrkB signaling: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| hippocampus | active_in | brain_region | 0.90 |
| neurons | active_in | cell_type | 0.90 |
| PI3K-AKT-mTOR signaling | crosstalk_with | pathway | 0.70 |
| unfolded protein response | crosstalk_with | pathway | 0.70 |
| prefrontal cortex | active_in | brain_region | 0.60 |
| CREB signaling | crosstalk_with | pathway | 0.60 |
| synaptic plasticity | crosstalk_with | pathway | 0.60 |
| microglia | active_in | cell_type | 0.60 |
| astrocytes | active_in | cell_type | 0.60 |
| cortex | active_in | brain_region | 0.60 |
| NF-kB signaling | crosstalk_with | pathway | 0.60 |
| neural stem cells | active_in | cell_type | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| BDNF | participates_in | gene | 0.90 |
| CREB | participates_in | gene | 0.90 |
| Alzheimer's disease | involves | disease | 0.90 |
| PI3K | participates_in | gene | 0.80 |
| ERK | participates_in | gene | 0.80 |
| endosome | involved_in | organelle | 0.70 |
| depression | involves | disease | 0.70 |
| anxiety | involves | disease | 0.70 |
| neuroinflammation | involves | disease | 0.70 |
| GFAP | participates_in | gene | 0.70 |
| JNK | participates_in | gene | 0.60 |
| AKT | participates_in | gene | 0.60 |
| AMPA receptor | activates | receptor | 0.60 |
| TNF receptor | activates | receptor | 0.60 |
| BIN1 | participates_in | gene | 0.60 |
| TRKB | participates_in | gene | 0.60 |
| APP | participates_in | gene | 0.60 |
| obesity | involves | disease | 0.60 |
| IBA1 | participates_in | gene | 0.60 |
| TNF | participates_in | gene | 0.60 |
| axon | involved_in | organelle | 0.60 |
| NGF | participates_in | gene | 0.60 |
| stroke | involves | disease | 0.60 |
| ERK1 | participates_in | gene | 0.60 |
| CCL2 | participates_in | gene | 0.60 |
| aging | involves | disease | 0.60 |
| GABA | participates_in | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||