gene

VMAT2

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about VMAT2: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

27Connections
0Hypotheses
0Analyses
14Outgoing
13Incoming

Summary

VMAT2 is a gene implicated in neurodegeneration research. Key relationships include: activates, implicated in. Associated with Inflammation, Neuroinflammation, Parkinson. Connected to 16 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolVMAT2
Full NameVesicular Monoamine Transporter 2
Chromosome10q25.2
FunctionVMAT2 mediates vesicular uptake of monoamines
Primary Expressionall monoaminergic neurons (dopaminergic, serotonergic, noradrenergic)
Molecular Weight56 kDa
Amino Acids525 aa
Exons18
PathwaysAutophagy, Mapk, Mtor
NCBI Gene ID6844
Ensembl IDENSG00000165646
OMIM193001
GeneCardsVMAT2
Human Protein AtlasVMAT2
CompanyTeva Pharmaceutical
Associated DiseasesParkinson's disease
Known Drugs/Compoundslevodopa
InteractionsMTOR, NEURON, NEUROINFLAMMATION, NURR1, AUTOPHAGY, PARKINSON'S DISEASE
KG Connections27 knowledge graph edges
DatabasesGeneCardsUniProtHPASTRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Vesicular Monoamine Transporter (VMAT) Modulators for Parkinson's Disease

company · 593 words

Atypical Parkinsonism

disease · 6876 words

Alpha-Synuclein Pathology

mechanism · 6288 words

Therapeutics

index · 5665 words

ALS Failed Approaches Analysis

mechanism · 4973 words

Huntington's Disease

disease · 4606 words

Pathway Diagram

graph TD
    VMAT2["VMAT2"]
    Neuroinflammation{"Neuroinflammation"}
    VMAT2 -->|"activates"| Neuroinflammation
    Parkinson{"Parkinson"}
    VMAT2 -->|"activates"| Parkinson
    Inflammation{"Inflammation"}
    VMAT2 -->|"activates"| Inflammation
    NEURON["NEURON"]
    VMAT2 -->|"activates"| NEURON
    NEUROINFLAMMATION["NEUROINFLAMMATION"]
    VMAT2 -->|"activates"| NEUROINFLAMMATION
    MTOR["MTOR"]
    VMAT2 -->|"activates"| MTOR
    Mtor(["Mtor"])
    VMAT2 -->|"activates"| Mtor
    Autophagy(["Autophagy"])
    VMAT2 -->|"activates"| Autophagy
    Mapk(["Mapk"])
    VMAT2 -->|"activates"| Mapk
    AUTOPHAGY["AUTOPHAGY"]
    AUTOPHAGY -->|"activates"| VMAT2
    PARKINSON_S_DISEASE["PARKINSON'S DISEASE"]
    PARKINSON_S_DISEASE -->|"activates"| VMAT2
    AMPK["AMPK"]
    AMPK -->|"activates"| VMAT2
    PARKINSON["PARKINSON"]
    PARKINSON -->|"activates"| VMAT2
    NURR1["NURR1"]
    NURR1 -->|"activates"| VMAT2
    ALPHA_SYNUCLEIN["ALPHA-SYNUCLEIN"]
    ALPHA_SYNUCLEIN -->|"activates"| VMAT2

Outgoing (14)

TargetRelationTypeStr
Neuroinflammationactivatesdisease0.65
Parkinsonactivatesdisease0.65
Inflammationactivatesdisease0.65
MTORactivatesgene0.60
NEURONactivatesgene0.60

Incoming (13)

SourceRelationTypeStr
NURR1activatesgene0.60
AUTOPHAGYactivatesgene0.60
PARKINSON'S DISEASEactivatesgene0.60
AMPKactivatesgene0.60
PARKINSONactivatesgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found