Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about dopaminergic neurons: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Cell Type | dopaminergic neurons |
| Also Known As | DA neurons, Dopamine neurons, Dopaminergic cells, Substantia nigra neurons |
| Key Pathways | Dopamine biosynthesis (TH → DOPA → DA), SNCA aggregation (Lewy bodies), PINK1/Parkin mitophagy, Complex I/mitochondrial vulnerability, Neuromelanin accumulation |
| Associated Diseases | Parkinson's disease (selective degeneration), Multiple system atrophy, Progressive supranuclear palsy, Schizophrenia (dysfunction), ADHD (reduced function) |
| Related Genes | alpha-synuclein, METTL3, OTUD6A, PINK1, neurotrophic factors, PARKIN |
| Linked Hypotheses | 64 hypotheses |
Knowledge base pages for this entity
graph TD
dopaminergic_neurons["dopaminergic neurons"] -->|"expressed in"| dopamine["dopamine"]
style dopamine fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
dopaminergic_neurons["dopaminergic neurons"] -->|"active in"| oxidative_stress_response["oxidative stress response"]
style oxidative_stress_response fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
dopaminergic_neurons["dopaminergic neurons"] -->|"expressed in"| substantia_nigra["substantia nigra"]
style substantia_nigra fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
dopaminergic_neurons["dopaminergic neurons"] -->|"expressed in"| substantia_nigra_pars_compacta["substantia nigra pars compacta"]
style substantia_nigra_pars_compacta fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
dopaminergic_neurons["dopaminergic neurons"] -->|"expresses"| mitophagy["mitophagy"]
style mitophagy fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
dopaminergic_neurons["dopaminergic neurons"] -->|"activates"| neurodegeneration["neurodegeneration"]
style neurodegeneration fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
dopaminergic_neurons["dopaminergic neurons"] -->|"associated"| Parkinson_s_Disease["Parkinson's Disease"]
style Parkinson_s_Disease fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
lipid_accumulation["lipid accumulation"] -->|"drives"| dopaminergic_neurons["dopaminergic neurons"]
style lipid_accumulation fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
USP30["USP30"] -->|"protects against"| dopaminergic_neurons["dopaminergic neurons"]
style USP30 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
Parkinson_s_Disease_1["Parkinson's Disease"] -->|"causes"| dopaminergic_neurons["dopaminergic neurons"]
style Parkinson_s_Disease_1 fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
Emodin["Emodin"] -->|"protects against"| dopaminergic_neurons["dopaminergic neurons"]
style Emodin fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
PS_NPs["PS-NPs"] -.->|"inhibits"| dopaminergic_neurons["dopaminergic neurons"]
style PS_NPs fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
style dopaminergic_neurons fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold| Target | Relation | Type | Str |
|---|---|---|---|
| oxidative stress response | active_in | pathway | 0.75 |
| substantia nigra | expressed_in | brain_region | 0.70 |
| substantia nigra pars compacta | expressed_in | brain_region | 0.70 |
| mitophagy | expresses | process | 0.70 |
| neurodegeneration | activates | disease | 0.70 |
| Parkinson's Disease | associated_with | disease | 0.70 |
| Parkinson's disease | regulates | disease | 0.60 |
| neurodegeneration | regulates | disease | 0.60 |
| pyroptosis | activates | process | 0.60 |
| ferroptosis | protects_against | process | 0.60 |
| Parkinson's disease | activates | disease | 0.60 |
| neuroinflammation | activates | disease | 0.60 |
| autophagy pathway | active_in | pathway | 0.55 |
| calcium signaling | active_in | pathway | 0.55 |
| mitochondrial function | active_in | pathway | 0.55 |
| glutamate signaling | active_in | pathway | 0.55 |
| epigenetic regulation | active_in | pathway | 0.55 |
| Source | Relation | Type | Str |
|---|---|---|---|
| lipid accumulation | drives | process | 1.00 |
| USP30 | protects_against | gene | 1.00 |
| Parkinson's Disease | causes | disease | 0.95 |
| Emodin | protects_against | drug | 0.91 |
| PS-NPs | inhibits | drug | 0.90 |
| alpha-synuclein | causes | protein | 0.90 |
| Parkinson's disease | affects | disease | 0.90 |
| neurodegeneration | affects | disease | 0.90 |
| neuroinflammation | affects | disease | 0.90 |
| neuroinflammation | causes | process | 0.90 |
| METTL3 | expressed_in | gene | 0.90 |
| OTUD6A | upregulates | gene | 0.90 |
| PINK1 | protects_against | gene | 0.85 |
| lipid droplet accumulation | contributes_to | process | 0.85 |
| oxidative stress | contributes_to | process | 0.85 |
| neurotrophic factors | protects_against | protein | 0.85 |
| PARKIN | expressed_in | gene | 0.80 |
| ASK1 | causes_apoptosis_of | gene | 0.80 |
| α-synuclein | causes | protein | 0.70 |
| excess intracellular calcium | activates | process | 0.70 |
| Parkinson's disease | causes | disease | 0.70 |
| striatum | expressed_in | brain_region | 0.70 |
| BMAL1 | regulates | gene | 0.70 |
| MLKL | regulates | protein | 0.70 |
| SNCA | causes | protein | 0.70 |
| SNCA | expressed_in | protein | 0.70 |
| PPARGC1A | expressed_in | protein | 0.70 |
| aging | causes | process | 0.70 |
| acupuncture | activates | process | 0.70 |
| oxidative stress | causes | process | 0.70 |
| aging | affects | disease | 0.70 |
| unfolded protein response | active_in | pathway | 0.70 |
| NLRP3 | expressed_in | gene | 0.70 |
| LRRK2 | expressed_in | gene | 0.70 |
| GDNF | protects_against | gene | 0.70 |
| SNCA | promotes | protein | 0.70 |
| GBA1 | expressed_in | gene | 0.70 |
| ALS | expressed_in | gene | 0.65 |
| HCRTR1 | expressed_in | gene | 0.60 |
| PLIN2 | activates | gene | 0.60 |
| TH | regulates | gene | 0.60 |
| GAPDH | regulates | gene | 0.60 |
| GFAP | regulates | gene | 0.60 |
| MAP1LC3B | regulates | gene | 0.60 |
| IL6 | regulates | gene | 0.60 |
| IL1B | regulates | gene | 0.60 |
| ATG5 | regulates | gene | 0.60 |
| NLRP3 | regulates | gene | 0.60 |
| ACTB | regulates | gene | 0.60 |
| ATG7 | regulates | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
neurodegeneration | 2026-04-13 | 0 hypotheses
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||