cell_type

dopaminergic neurons

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about dopaminergic neurons: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

643Connections
0Hypotheses
1Analyses
17Outgoing
50Incoming

No summary available yet. View on Wiki →

🧫 Cell Type Info
Cell Typedopaminergic neurons
Also Known AsDA neurons, Dopamine neurons, Dopaminergic cells, Substantia nigra neurons
Key PathwaysDopamine biosynthesis (TH → DOPA → DA), SNCA aggregation (Lewy bodies), PINK1/Parkin mitophagy, Complex I/mitochondrial vulnerability, Neuromelanin accumulation
Associated DiseasesParkinson's disease (selective degeneration), Multiple system atrophy, Progressive supranuclear palsy, Schizophrenia (dysfunction), ADHD (reduced function)
Related Genesalpha-synuclein, METTL3, OTUD6A, PINK1, neurotrophic factors, PARKIN
Linked Hypotheses64 hypotheses

Wiki Pages (20)

Knowledge base pages for this entity

cbs-psp-daily-action-plan

therapeutic · 30834 words

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

therapeutic · 15794 words

Progressive Supranuclear Palsy (PSP)

disease · 12907 words

Corticobasal Syndrome (CBS)

disease · 11374 words

Novel Therapy Index

idea · 10647 words

Pathway Diagram

graph TD
    dopaminergic_neurons["dopaminergic neurons"] -->|"expressed in"| dopamine["dopamine"]
    style dopamine fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    dopaminergic_neurons["dopaminergic neurons"] -->|"active in"| oxidative_stress_response["oxidative stress response"]
    style oxidative_stress_response fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    dopaminergic_neurons["dopaminergic neurons"] -->|"expressed in"| substantia_nigra["substantia nigra"]
    style substantia_nigra fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    dopaminergic_neurons["dopaminergic neurons"] -->|"expressed in"| substantia_nigra_pars_compacta["substantia nigra pars compacta"]
    style substantia_nigra_pars_compacta fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    dopaminergic_neurons["dopaminergic neurons"] -->|"expresses"| mitophagy["mitophagy"]
    style mitophagy fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    dopaminergic_neurons["dopaminergic neurons"] -->|"activates"| neurodegeneration["neurodegeneration"]
    style neurodegeneration fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    dopaminergic_neurons["dopaminergic neurons"] -->|"associated"| Parkinson_s_Disease["Parkinson's Disease"]
    style Parkinson_s_Disease fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    lipid_accumulation["lipid accumulation"] -->|"drives"| dopaminergic_neurons["dopaminergic neurons"]
    style lipid_accumulation fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    USP30["USP30"] -->|"protects against"| dopaminergic_neurons["dopaminergic neurons"]
    style USP30 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    Parkinson_s_Disease_1["Parkinson's Disease"] -->|"causes"| dopaminergic_neurons["dopaminergic neurons"]
    style Parkinson_s_Disease_1 fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    Emodin["Emodin"] -->|"protects against"| dopaminergic_neurons["dopaminergic neurons"]
    style Emodin fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    PS_NPs["PS-NPs"] -.->|"inhibits"| dopaminergic_neurons["dopaminergic neurons"]
    style PS_NPs fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    style dopaminergic_neurons fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (191)

TargetRelationTypeStr
oxidative stress responseactive_inpathway0.75
substantia nigraexpressed_inbrain_region0.70
substantia nigra pars compactaexpressed_inbrain_region0.70
mitophagyexpressesprocess0.70
neurodegenerationactivatesdisease0.70

Incoming (452)

SourceRelationTypeStr
lipid accumulationdrivesprocess1.00
USP30protects_againstgene1.00
Parkinson's Diseasecausesdisease0.95
Emodinprotects_againstdrug0.91
PS-NPsinhibitsdrug0.90

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

How does PSEN2 mechanistically regulate α-synuclein expression and pathology in

neurodegeneration | 2026-04-13 | 0 hypotheses

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found