concept

AMYLOID PLAQUES

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about AMYLOID PLAQUES: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

71Connections

0Hypotheses

2Analyses

18Outgoing

30Incoming

0Experiments

No summary available yet. View on Wiki →

💡 Concept Info

Name	AMYLOID PLAQUES
Key Genes/Proteins	TAU
Related Diseases	NEURODEGENERATION, ALZHEIMER'S DISEASE, INFLAMMATION, NEUROINFLAMMATION, CEREBRAL AMYLOID ANGIOPATHY

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    AMYLOID_PLAQUES["AMYLOID PLAQUES"]
    AMYLOID_PLAQUES -->|"involved_in"| Alzheimer_s_Disease["Alzheimer's Disease"]
    AMYLOID_PLAQUES -.biomarker for.-> Alzheimer_S_Disease["Alzheimer'S Disease"]
    AMYLOID_PLAQUES -->|"correlates_with"| Lipid_Droplet_Load["Lipid Droplet Load"]
    AMYLOID_PLAQUES -->|"causes"| Neurodegeneration["Neurodegeneration"]
    AMYLOID_PLAQUES -.biomarker for.-> Alzheimer_Disease["Alzheimer Disease"]
    AMYLOID_PLAQUES -.biomarker for.-> Alzheimer_s_disease["Alzheimer's disease"]
    AMYLOID_PLAQUES -->|"interacts"| NEURODEGENERATION["NEURODEGENERATION"]
    APP["APP"] -->|"causes"| AMYLOID_PLAQUES
    Amyloid_Beta["Amyloid Beta"] -->|"mediates"| AMYLOID_PLAQUES
    microglial_efferocytosis["microglial efferocytosis"] -->|"activates"| AMYLOID_PLAQUES
    alpha_synuclein["alpha-synuclein"] -->|"activates"| AMYLOID_PLAQUES
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] -->|"interacts"| AMYLOID_PLAQUES
    ASTROCYTES["ASTROCYTES"] -->|"interacts"| AMYLOID_PLAQUES
    MICROGLIA["MICROGLIA"] -->|"activates"| AMYLOID_PLAQUES
    Microglia_Replacement["Microglia Replacement"] -->|"suppresses"| AMYLOID_PLAQUES

Outgoing (28)

Target	Relation	Type	Str
NEURODEGENERATION	interacts_with	phenotype	0.65
TAU	protects_against	protein	0.65
TAU	phosphorylates	protein	0.65
ALZHEIMER'S DISEASE	produces	disease	0.65
INFLAMMATION	causes	phenotype	0.65
INFLAMMATION	produces	phenotype	0.65
METFORMIN	protects_against	drug	0.65
NEUROINFLAMMATION	causes	phenotype	0.65
CEREBRAL AMYLOID ANGIOPATHY	causes	disease	0.65
CEREBRAL AMYLOID ANGIOPATHY	produces	disease	0.65
ALZHEIMER'S DISEASE	expressed_in	disease	0.55
CA1	associated_with	brain_region	0.50
HIPPOCAMPUS	associated_with	brain_region	0.45
CORTEX	associated_with	brain_region	0.45
LECANEMAB	associated_with	drug	0.45
ADUCANUMAB	associated_with	drug	0.45
DONANEMAB	associated_with	drug	0.45
METFORMIN	associated_with	drug	0.45

Incoming (43)

Source	Relation	Type	Str
NEURODEGENERATION	inhibits	phenotype	0.70
NEURONS	regulates	cell_type	0.70
ALZHEIMER'S DISEASE	interacts_with	disease	0.65
ASTROCYTES	interacts_with	cell_type	0.65
MICROGLIA	activates	cell_type	0.65
ALZHEIMER'S DISEASE	inhibits	disease	0.65
MICROGLIA	causes	cell_type	0.65
MICROGLIA	regulates	cell_type	0.65
LECANEMAB	causes	drug	0.65
DONANEMAB	protects_against	drug	0.65
AMYLOID	causes	protein	0.65
APOE	inhibits	gene	0.65
APOE	regulates	gene	0.65
MICROGLIA	protects_against	cell_type	0.65
AMYLOID	inhibits	protein	0.65
AMYLOID	increases_risk	protein	0.65
MICROGLIA	interacts_with	cell_type	0.65
ADAM10	interacts_with	gene	0.65
ADAM10	produces	gene	0.65
APP	degrades	gene	0.65
PHAGOCYTOSIS	transports	phenotype	0.65
ALZHEIMER'S DISEASE	implicated_in	disease	0.60
INFLAMMATION	expressed_in	phenotype	0.55
AMYLOID	participates_in	protein	0.55
ADAM10	expressed_in	gene	0.55
TAU	associated_with	protein	0.50
ENTORHINAL CORTEX	associated_with	brain_region	0.45
CEREBRAL CORTEX	associated_with	brain_region	0.45
APOE	associated_with	gene	0.45
APOE4	associated_with	gene	0.45

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (2)

Scientific analyses that reference this entity

Why does the V1613M variant reduce amyloid pathology when ABCA7 loss-of-function

neurodegeneration | 2026-04-14 | 2 hypotheses Top: 0.619

What evidence supports Cdk5 activation as THE primary cause of AD versus other e

neurodegeneration | 2026-04-10 | 0 hypotheses

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

AMYLOID PLAQUES

Understanding Entity Pages

Wiki Pages (20)

Sleep and Circadian Dysfunction in Alzheimer's Disease

Microglia CD8+ T Cell Recruitment -- Supplementary WW Content

Myoclonus and Cortical Hyperexcitability in Corticobasal Syndrome

PI-2620 Tau PET in PSP

neuroinflammation

Alzheimer's Disease

Microglial Cells — Cell Type Hierarchy

NTF4 Protein

TREM2 Mechanism Hub

Mitochondrial Quality Control

Astrocyte Reactivity Mechanism

GSK-3β in Neurodegeneration

oxidative-stress-comparison

Blood-Brain Barrier Dysfunction in Neurodegeneration

APOC4 — Apolipoprotein C-IV

amyloid-beta-metalloproteinases

Mitophagy Pathway in Neurodegeneration

TREM2 Microglial Signaling Pathway in Neurodegeneration

DIAN-TU-001 Trial (NCT01760005)

AI and Machine Learning in Neurodegeneration