Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about ank1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Gene Symbol | ANK1 |
| Aliases | Ankyrin 1 |
| Function | Ankyrin 1 is a membrane-associated protein that serves as a critical anchor between the plasma membrane and the underlying cytoskeleton. |
| Primary Expression | Substantia Nigra |
| Molecular Weight | 210 kDa |
| Pathways | Alpha-Synuclein |
| Ensembl ID | ENSG00000162678 |
| GeneCards | ANK1 |
| Human Protein Atlas | ANK1 |
| Associated Diseases | Alzheimer, Parkinson |
| KG Connections | 7 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
ANK1["ANK1"]
ANK1 -->|"expressed in"| Neurodegeneration["Neurodegeneration"]
ANK1 -->|"expressed in"| Als["Als"]
ANK1 -->|"expressed in"| ALS["ALS"]
ANK1 -->|"expressed in"| SNCA["SNCA"]
ANK1 -->|"expressed in"| Neuron["Neuron"]
ANK1 -->|"expressed in"| IFN__["IFN-Gamma"]
ANK1 -->|"expressed in"| ALPHA_SYNUCLEIN["ALPHA-SYNUCLEIN"]
ANK1 -->|"expressed in"| Alpha_Synuclein["Alpha-Synuclein"]
NEURODEGENERATION["NEURODEGENERATION"] -->|"expressed in"| ANK1
SNCA -->|"expressed in"| ANK1
IFN["IFN"] -->|"expressed in"| ANK1| Target | Relation | Type | Str |
|---|---|---|---|
| RIT2 | expressed_in | gene | 0.50 |
| ALZHEIMER | expressed_in | gene | 0.50 |
| PARKINSON | expressed_in | gene | 0.50 |
| Parkinson's Disease | expressed_in | disease | 0.50 |
| disease | expressed_in | disease | 0.50 |
| ALZHEIMER'S | expressed_in | concept | 0.50 |
| PARKINSON'S | expressed_in | concept | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| RIT2 | associated_with | gene | 0.60 |
| SNCA | expressed_in | gene | 0.60 |
| NEURODEGENERATION | expressed_in | gene | 0.60 |
| GENES | associated_with | gene | 0.60 |
| PARKINSON | associated_with | gene | 0.60 |
| ALZHEIMER | associated_with | gene | 0.60 |
| AND | associated_with | gene | 0.60 |
| IFN | expressed_in | gene | 0.60 |
| benchmark_ot_ad_answer_key:ANK1 | data_in | dataset_row | 0.00 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||