gene

anxa11

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about anxa11: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

65Connections

0Hypotheses

0Analyses

50Outgoing

7Incoming

0Experiments

0Debates

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🧬 Gene Info

Gene Symbol	ANXA11
Full Name	Annexin A11
Chromosome	10q22.3
Function	N-terminal low-complexity domain (LCD, residues 1–188): An intrinsically disordered region enriched in glycine and proline residues.
Primary Expression	Motor neurons, Cortex, Hippocampus, Spinal cord
Amino Acids	505 aa
UniProt ID	P50995
Ensembl ID	ENSG00000122359
OMIM	602572
GeneCards	ANXA11
Human Protein Atlas	ANXA11
Associated Diseases	Alzheimer's disease, amyotrophic lateral sclerosis, frontotemporal dementia, FTLD-TDP, neurodegeneration, NTDs
Interactions	TARDBP, TDP-43
KG Connections	62 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: anxa11 — AlphaFold P50995 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

ANXA11 — Annexin A11

gene · 1239 words

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Pathway Diagram

graph TD
    ANXA11["ANXA11"]
    ANXA11 -->|"involved_in"| Amyloid_Filaments["Amyloid Filaments"]
    ANXA11 -.biomarker for.-> FTLD_TDP_Type_C["FTLD-TDP Type C"]
    ANXA11 -->|"binds"| miR_16_5p["miR-16-5p"]
    ANXA11 -.biomarker for.-> bladder_cancer["bladder cancer"]
    ANXA11 -->|"interacts"| TDP_43["TDP-43"]
    ANXA11 -.biomarker for.-> IgG4_related_cholangitis["IgG4-related cholangitis"]
    ANXA11 -->|"expressed in"| cholangiocyte["cholangiocyte"]
    ANXA11 -->|"regulates"| calcium_homeostasis["calcium homeostasis"]
    miR_16_5p -->|"regulates"| ANXA11
    TARDBP["TARDBP"] -->|"interacts"| ANXA11

Outgoing (58)

Target	Relation	Type	Str
FTLD-TDP	associated_with	disease	0.95
Amyloid Filaments	involved_in	process	0.92
FTLD-TDP Type C	biomarker_for	disease	0.90
TDP-43	aggregates_with	protein	0.90
amyotrophic lateral sclerosis	associated_with	disease	0.80
miR-16-5p	binds	entity	0.80
bladder cancer	biomarker_for	disease	0.80
TDP-43	interacts_with	protein	0.80
IgG4-related cholangitis	biomarker_for	disease	0.80
cholangiocyte	expressed_in	cell_type	0.80
calcium homeostasis	regulates	biological_process	0.80
stress granules	regulates	entity	0.80
Alzheimer's disease	associated_with	disease	0.70
NTDs	associated_with	phenotype	0.70
neurodegeneration	causes	disease	0.60
TDP-43	associated_with	gene	0.60
frontotemporal dementia	causes	disease	0.60
CCNF	causes	gene	0.60
CHCHD10	causes	gene	0.60
CHCHD2	causes	gene	0.60
CHMP2B	causes	gene	0.60
CYLD	causes	gene	0.60
FUS	causes	gene	0.60
GRN	causes	gene	0.60
MAPT	causes	gene	0.60
OPTN	causes	gene	0.60
PRNP	causes	gene	0.60
SIGMAR1	causes	gene	0.60
SQSTM1	causes	gene	0.60
TARDBP	causes	gene	0.60
TBK1	causes	gene	0.60
TMEM106B	causes	gene	0.60
UBQLN2	causes	gene	0.60
VCP	causes	gene	0.60
CCNF	associated_with	gene	0.60
CHCHD10	associated_with	gene	0.60
CHCHD2	associated_with	gene	0.60
CHMP2B	associated_with	gene	0.60
CYLD	associated_with	gene	0.60
FUS	associated_with	gene	0.60
GRN	associated_with	gene	0.60
MAPT	associated_with	gene	0.60
OPTN	associated_with	gene	0.60
SIGMAR1	associated_with	gene	0.60
SQSTM1	associated_with	gene	0.60
TBK1	associated_with	gene	0.60
TMEM106B	associated_with	gene	0.60
UBQLN2	associated_with	gene	0.60
AND	associated_with	gene	0.60
NEURODEGENERATIVE DISEASES	associated_with	gene	0.60

Incoming (7)

Source	Relation	Type	Str
miR-16-5p	regulates	entity	0.80
AMYLOID	associated_with	gene	0.60
FTLD	associated_with	gene	0.60
NEURODEGENERATIVE DISEASES	associated_with	gene	0.60
ALS	associated_with	gene	0.60
TARDBP	interacts_with	gene	0.60
TDP-43	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity