protein

APOE3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about APOE3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

617Connections

2Hypotheses

1Analyses

50Outgoing

50Incoming

9Experiments

Summary

APOE3 is a protein involved in neurodegeneration research. Key relationships include: activates, expressed in, associated with. Associated with ALS, Aging, Als. Connected to 273 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	APOE3
Aliases	apoe3
Associated Diseases	ALS, Aging, Alzheimer, Alzheimer's Disease
Interactions	APOE4, LDLR, APOE, NEURODEGENERATION, ALZHEIMER'S DISEASE, TAU PATHOLOGY
KG Connections	617 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    APOE3["APOE3"] -->|"protects against"| amyloid_pathology["amyloid pathology"]
    APOE3["APOE3"] -.->|"inhibits"| vessel_associated_gliosis["vessel-associated gliosis"]
    APOE3["APOE3"] -->|"causes"| retinal_ganglion_cell_loss["retinal ganglion cell loss"]
    APOE3["APOE3"] -->|"contributes to"| glaucoma["glaucoma"]
    APOE3["APOE3"] -->|"regulates"| tau_pathology["tau pathology"]
    APOE3["APOE3"] -->|"protects against"| Alzheimer_s_disease["Alzheimer's disease"]
    ABCA1["ABCA1"] -->|"associated"| APOE3["APOE3"]
    APOE["APOE"] -->|"activates"| APOE3["APOE3"]
    APOE__4_ALLELE["APOE Epsilon4 ALLELE"] -->|"therapeutic target"| APOE3["APOE3"]
    APOE4["APOE4"] -->|"associated"| APOE3["APOE3"]
    style APOE3 fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (438)

Target	Relation	Type	Str
APOE4	activates	gene	1.00
Alzheimer	activates	disease	1.00
APOE	activates	gene	1.00
Neurodegeneration	activates	disease	0.95
Als	activates	disease	0.95
Alzheimer	protects_against	disease	0.95
dystrophic neurites	protects_against	phenotype	0.92
amyloid pathology	protects_against	phenotype	0.90
LDLR binding	impairs	process	0.90
ALZHEIMER'S DISEASE	protects_against	gene	0.90
ALZHEIMER'S DISEASE	activates	gene	0.90
AMYLOID	activates	gene	0.90
ALZHEIMER	activates	gene	0.90
Stem Cell	activates	pathway	0.90
Alzheimer's Disease	associated_with	disease	0.88
Alzheimer	expressed_in	disease	0.85
oxidative stress response	participates_in	pathway	0.85
intracellular lipid homeostasis	associated_with	process	0.85
LRP8	activates	protein	0.85
APOE4	suppresses	protein	0.85
vessel-associated gliosis	inhibits	phenotype	0.80
retinal ganglion cell loss	causes	phenotype	0.80
glaucoma	contributes_to	disease	0.80
LDLR	binds	protein	0.80
Alzheimer's Disease	protects_against	disease	0.80
ALZHEIMER	expressed_in	gene	0.80
ALZHEIMER	protects_against	gene	0.80
Alzheimer	associated_with	disease	0.75
Tauopathy	activates	disease	0.75
Als	interacts_with	disease	0.75
Neurodegeneration	protects_against	disease	0.75
Alzheimer	regulates	disease	0.75
Alzheimer	implicated_in	disease	0.75
DAM microglia	expressed_in	cell_type	0.75
synaptic plasticity	participates_in	pathway	0.75
tau pathology	regulates	process	0.70
APOE	associated_with	gene	0.70
APOE4	associated_with	gene	0.70
TAU PATHOLOGY	protects_against	gene	0.70
APOE4	inhibits	gene	0.70
Cholesterol	interacts_with	pathway	0.70
APOE	expressed_in	gene	0.70
APOE4	interacts_with	gene	0.70
APOE	interacts_with	gene	0.70
APOE	regulates	gene	0.70
AUTOPHAGY	activates	gene	0.70
Autophagy	activates	pathway	0.70
ALZHEIMER'S DISEASE	regulates	gene	0.70
TAUOPATHY	activates	gene	0.70
APP	activates	gene	0.70

Incoming (179)

Source	Relation	Type	Str
NEURODEGENERATION	activates	gene	0.90
APOE4	converts_to	gene	0.80
TREM2 R47H	affects	gene	0.80
NEURON	activates	gene	0.70
TAU	activates	gene	0.70
ALZHEIMER'S DISEASE	expressed_in	gene	0.70
NEURODEGENERATION	protects_against	gene	0.70
APOE2	associated_with	gene	0.70
APOE	impairs	gene	0.65
APOE	targets	gene	0.65
APOE	promotes	gene	0.65
APOE2	targets	gene	0.65
APOE	protects_against	gene	0.65
APOE2	protects_against	gene	0.65
APOE	regulates	gene	0.65
APOE2	upregulates	entity	0.60
APOE2	activates	entity	0.60
ABCA1	associated_with	gene	0.60
APOE	activates	gene	0.60
APOE Ε4 ALLELE	therapeutic_target	gene	0.60
APOE4	associated_with	gene	0.60
APOE4	inhibits	gene	0.60
MICROGLIA	activates	gene	0.60
ALZHEIMER'S DISEASE	activates	gene	0.60
AGING	associated_with	gene	0.60
AGING	contributes_to	gene	0.60
ALZHEIMER'S DISEASE	protects_against	gene	0.60
ABCA1	activates	gene	0.60
ASTROCYTES	activates	gene	0.60
JUN	activates	gene	0.60
APOE4	activates	gene	0.60
ALZHEIMER	activates	gene	0.60
TAU PATHOLOGY	activates	gene	0.60
AMYLOID	activates	gene	0.60
ALZHEIMER'S DISEASE	associated_with	gene	0.60
APOE Ε4 ALLELE	associated_with	gene	0.60
MICROGLIA	associated_with	gene	0.60
ALZHEIMER	associated_with	gene	0.60
ASTROCYTE	associated_with	gene	0.60
TAU	associated_with	gene	0.60
ALZHEIMER	expressed_in	gene	0.60
NEURODEGENERATIVE DISEASES	expressed_in	gene	0.60
CANCER	expressed_in	gene	0.60
NEURODEGENERATION	inhibits	gene	0.60
TAU	inhibits	gene	0.60
ALZHEIMER'S DISEASE	inhibits	gene	0.60
ERK1	activates	gene	0.60
CFOS	activates	gene	0.60
LGALS3	activates	gene	0.60
APP/PS1	activates	gene	0.60

Targeting Hypotheses (2)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Prime Editing Precision Correction of APOE4 to APOE3 in Micr	0.622	neurodegeneration	CRISPR-based therapeutic approaches for
Targeted APOE4-to-APOE3 Base Editing Therapy	0.526	neurodegeneration	APOE4 structural biology and therapeutic

Mentioning Analyses (1)

Scientific analyses that reference this entity

APOE4 structural biology and therapeutic targeting strategies

neurodegeneration | 2026-04-01 | 7 hypotheses Top: 0.595

Experiments (9)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
Sex Differences in Alzheimer's Disease — mechanisms and therapeutic im	clinical	Alzheimer's Disease	0.400	0.50	human	proposed	$7,500,000
AD Combination Therapy Trial: Anti-Aβ + Anti-Tau	clinical	Alzheimer's Disease	0.400	0.50	cell_line	proposed	$180,000
Biomarker-Guided Sequential Therapy Selection in Alzheimer's Disease	clinical	Alzheimer's Disease	0.400	0.50	human	proposed	$5,460,000
Why Does Amyloid Removal Only Slow Decline 27%? — Mechanistic investig	clinical	Alzheimer's Disease	0.400	0.50	human	proposed	$7,100,000
Blood-Based Biomarker Panel for Early AD Detection	clinical	Alzheimer's Disease	0.400	0.50	cell_line	proposed	$220,000
ApoE4 Function in Alzheimer's Disease	validation	Alzheimer's Disease	0.400	0.50	mouse	proposed	$360,000
CRISPR Gene Correction Approaches for CBS/PSP	clinical	Parkinson's Disease	0.400	0.50	human	proposed	$6,550,000
Down Syndrome Alzheimer's Disease: Mechanisms and Therapeutic Timing	clinical	Alzheimer's Disease	0.400	0.50	human	proposed	$7,500,000
s:** - Biochemical binding assays measuring PROTAC selectivity for APO	falsification	Neurodegeneration	0.400	0.50	cell_line	proposed	$100,000

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
An AAV capsid reprogrammed to bind human transferrin receptor mediates brain-wid [PMID:38753766]	Huang Q, Chan KY, Wu J, Botticello-Romer	Science	2024	1
ApoE in Alzheimer's disease: pathophysiology and therapeutic strategies. [PMID:36348357]	Raulin AC, Doss SV, Trottier ZA, Ikezu T	Mol Neurodegener	2022	1
APOE and Alzheimer's disease: advances in genetics, pathophysiology, and therape [PMID:33340485]	Serrano-Pozo A, Das S, Hyman BT	Lancet Neurol	2021	1
Alzheimer Disease: An Update on Pathobiology and Treatment Strategies. [PMID:31564456]	Long JM, Holtzman DM	Cell	2019	1
Apolipoprotein E and Alzheimer disease: pathobiology and targeting strategies. [PMID:31367008]	Yamazaki Y, Zhao N, Caulfield TR, Liu CC	Nat Rev Neurol	2019	1
The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Mic [PMID:28930663]	Krasemann S, Madore C, Cialic R, Baufeld	Immunity	2017	1
Modulating LRP1 Pathways in Alzheimer's Disease: Mechanistic Insights and Emergi [PMID:41772271]	Mushtaq T, Hameed H, Khan MA, Tariq U, H	Molecular neurobiology	2026	0
Macrophagic Sclerostin Loop2-ApoER2 Interaction Required by Sclerostin for Cardi [PMID:41276911]	Wang L, Tao X, Zhang N, Yang X, Jiang H	Adv Sci (Weinh)	2026	0
APOE Genotype Modulates the Relationship of Stroke With Dementia Risk: Associati [PMID:41404739]	Zhang CH, Huang LY, Feng YG, Tan CC, Tan	J Am Heart Assoc	2026	0
High- and Low-Fat Dairy Consumption and Long-Term Risk of Dementia: Evidence Fro [PMID:41406402]	Du Y, Borné Y, Samuelsson J, Glans I, Hu	Neurology	2026	0
Prime Editing of Alzheimer's Disease High-Risk APOE4 Allele by Brain-Directed Ad [PMID:41449667]	Günaydin C, Hackett NR, Wakim V, Sondhi	Hum Gene Ther	2026	0
The role of astrocytes in Alzheimer's disease: Pathophysiology, biomarkers, and [PMID:41527736]	Abedin MJ, Kastanenka KV	J Alzheimers Dis	2026	0
Endothelial TBK1 Deficiency Inhibits Endothelial-to-Mesenchymal Transition and A [PMID:41685426]	Pu Y, Dong P, He L, Huang J, Wu Y et al.	Circ Res	2026	0
Lipidome and proteome of astrocyte and microglia ApoE lipoprotein reveal differe [PMID:41692246]	Strickland MR, Wang Z, Golden LR, Wang H	J Lipid Res	2026	0
Protective mutations associated with APOE in Alzheimer's disease. [PMID:41703264]	Ma Y, Li Y, Wu G, Liu L, Tian M et al.	Mol Psychiatry	2026	0
HTRA1 and Brain Disorders: A Balancing Act Across Neurodegeneration and Repair. [PMID:41932381]	Hjæresen S, Gramkow ET, Zhang M, Svennin	Prog Neurobiol	2026	0
Trajectories of frailty, grip strength and gait speed preceding dementia: a nest [PMID:41936045]	Wu Z, Phyo AZZ, Cribb L, Vishwanath S, O	Age Ageing	2026	0
Amyloid-related imaging abnormalities in Japanese patients with Alzheimer's dise [PMID:41936348]	Shimasaki R, Kurihara M, Bannai T, Hatan	J Prev Alzheimers Dis	2026	0
Apolipoprotein E proteotyping as a valid alternative to genotyping in clinical p [PMID:41940854]	Alcalá Ramírez Del Puerto JM, Ortega-Mad	J Alzheimers Dis	2026	0
Opposing patterns of blood-brain barrier permeability and Alzheimer's disease bi [PMID:41942760]	Bernocchi F, Bonomi CG, Poli M, Di Donna	Neurological sciences : offici	2026	0

APOE3

Understanding Entity Pages

Summary

Wiki Pages (20)

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

Novel Therapy Index

Section 148: Advanced Nutritional Biochemistry in CBS/PSP

CBS/PSP Clinical Trials Guide

oxidative-stress-comparison

TREM2 Microglial Signaling Pathway in Neurodegeneration

Axonal Transport Dysfunction Comparison Across Neurodegenerative Diseases

protective-strategies-cbs-psp

blood-brain-barrier

Epigenetic Dysregulation Comparison -- AD/PD/ALS/FTD/HD

Splice-Modulating Therapies for Neurodegeneration

Bepranemab (UCB0107)

metabolic-dysfunction-neurodegeneration

Amyloid-beta Fibril Formation Pathway

er-stress-neurodegeneration

Alpha-Synuclein ESCRT-III Inhibition Mechanism

Etalanetug (E2814)

hyp_367280

Type 3 Diabetes Hypothesis of Alzheimer's Disease

Neuroinflammation in Parkinson's Disease