CFOS

Understanding Entity Pages

This page aggregates everything SciDEX knows about CFOS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

CFOS is a gene implicated in neurodegeneration research. Key relationships include: activates, implicated in, expressed in. Associated with Als, Alzheimer, Inflammation. Connected to 22 entities in the SciDEX knowledge graph.

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graph TD
    CFOS["CFOS (immediate early gene)"]
    ERK1["ERK1 (MAPK signaling)"]
    APP["APP (amyloid precursor)"]
    APOE["APOE (apolipoprotein E)"]
    APOE4["APOE4 (risk allele)"]
    IL6["IL-6 (cytokine)"]
    DLK["DLK (kinase)"]
    BBB["Blood-Brain Barrier"]
    Neuroinflammation["Neuroinflammation"]
    Alzheimer["Alzheimer's Disease"]
    ALS["Amyotrophic Lateral Sclerosis"]
    Neurodegeneration["Neurodegeneration"]
    AMYLOID["Amyloid pathology"]

    ERK1 -->|"phosphorylates"| CFOS
    CFOS -->|"transcriptional activation"| APOE
    CFOS -->|"upregulates"| APOE4
    CFOS -->|"activates"| APP
    APP -->|"feedback loop"| CFOS
    CFOS -->|"induces"| IL6
    CFOS -->|"activates"| DLK
    CFOS -->|"disrupts"| BBB
    CFOS -->|"promotes"| Neuroinflammation
    IL6 -->|"amplifies"| Neuroinflammation
    APP -->|"generates"| AMYLOID
    CFOS -->|"contributes to"| Alzheimer
    CFOS -->|"associated with"| ALS
    Neuroinflammation -->|"drives"| Neurodegeneration
    Alzheimer -->|"feedback activation"| CFOS

    style CFOS fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px
    style ERK1 fill:#4a1a6b
    style DLK fill:#4a1a6b
    style APOE fill:#4a1a6b
    style APP fill:#4a1a6b
    style IL6 fill:#ef5350
    style APOE4 fill:#ef5350
    style BBB fill:#ef5350
    style Neuroinflammation fill:#ef5350
    style AMYLOID fill:#ef5350
    style Alzheimer fill:#7d4200
    style ALS fill:#7d4200
    style Neurodegeneration fill:#7d4200