concept

LOCUS COERULEUS

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about LOCUS COERULEUS: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

149Connections

1Hypotheses

1Analyses

50Outgoing

35Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	LOCUS COERULEUS
Key Genes/Proteins	TAU, AMYLOID
Related Diseases	ALZHEIMER'S DISEASE, EXCITOTOXICITY, DOPAMINE
Linked Hypotheses	1 hypotheses

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    LOCUS_COERULEUS["LOCUS COERULEUS"]
    LOCUS_COERULEUS -->|"activates"| Norepinephrine["Norepinephrine"]
    LOCUS_COERULEUS -->|"interacts"| dorsolateral_septum["dorsolateral septum"]
    LOCUS_COERULEUS -->|"regulates"| stress["stress"]
    LOCUS_COERULEUS -->|"causes"| MICROGLIA["MICROGLIA"]
    LOCUS_COERULEUS -->|"regulates"| NEURONS["NEURONS"]
    LOCUS_COERULEUS -->|"promotes"| NEURON["NEURON"]
    CA1["CA1"] -->|"exacerbates"| LOCUS_COERULEUS
    HIPPOCAMPUS["HIPPOCAMPUS"] -->|"exacerbates"| LOCUS_COERULEUS
    DEPRESSION["DEPRESSION"] -->|"contributes to"| LOCUS_COERULEUS
    ALZHEIMER["ALZHEIMER"] -->|"regulates"| LOCUS_COERULEUS
    ALZHEIMER_S["ALZHEIMER'S"] -->|"regulates"| LOCUS_COERULEUS
    BDNF["BDNF"] -->|"regulates"| LOCUS_COERULEUS
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] -->|"regulates"| LOCUS_COERULEUS

Outgoing (65)

Target	Relation	Type	Str
MICROGLIA	causes	cell_type	0.65
ALZHEIMER'S DISEASE	causes	disease	0.65
TAU	phosphorylates	protein	0.65
EXCITOTOXICITY	causes	phenotype	0.65
ALZHEIMER'S DISEASE	activates	disease	0.65
ALZHEIMER'S DISEASE	treats	disease	0.65
AMYLOID	activates	protein	0.65
TAU	exacerbates	protein	0.65
ALZHEIMER'S DISEASE	protects_against	disease	0.65
ALZHEIMER'S DISEASE	produces	disease	0.65
ALZHEIMER'S DISEASE	interacts_with	disease	0.65
MICROGLIA	inhibits	cell_type	0.65
DOPAMINE	produces	phenotype	0.65
DOPAMINE	causes	phenotype	0.65
NEURONS	regulates	cell_type	0.60
NEURON	promotes	cell_type	0.60
NEURONS	promotes	cell_type	0.60
TH	implicated_in	gene	0.55
MITOCHONDRIAL DYSFUNCTION	implicated_in	phenotype	0.55
NEURON	associated_with	cell_type	0.50
LRP1	associated_with	gene	0.50
DOPAMINE	associated_with	phenotype	0.50
BDNF	associated_with	gene	0.45
NEURONS	associated_with	cell_type	0.45
LEWY BODIES	associated_with	phenotype	0.45
TAU	associated_with	protein	0.45
NOREPINEPHRINE	associated_with	phenotype	0.45
TH	associated_with	gene	0.45
AGING	associated_with	phenotype	0.45
EXCITOTOXICITY	associated_with	phenotype	0.45
AMYLOID	associated_with	protein	0.45
APOE4	associated_with	gene	0.45
APOPTOSIS	associated_with	phenotype	0.45
APP	associated_with	gene	0.45
AXL	associated_with	gene	0.45
MERTK	associated_with	gene	0.45
NEURODEGENERATION	co_discussed	disease	0.40
THALAMUS	co_discussed	brain_region	0.40
RAPHE	co_discussed	brain_region	0.40
NEURON	co_discussed	cell_type	0.40
NEURONS	co_discussed	cell_type	0.40
PARKIN	co_discussed	gene	0.40
PARKINSON	co_discussed	disease	0.40
PARKINSON'S	co_discussed	disease	0.40
PARKINSON'S DISEASE	co_discussed	disease	0.40
NEURODEGENERATION	associated_with	process	0.35
NEUROINFLAMMATION	associated_with	process	0.35
MICROGLIA	activates	cell_type	0.35
NEURON	regulates	cell_type	0.35
TAU	regulates	protein	0.35

Incoming (84)

Source	Relation	Type	Str
CA1	exacerbates	brain_region	0.65
HIPPOCAMPUS	exacerbates	brain_region	0.65
TAU	activates	protein	0.65
APOPTOSIS	causes	phenotype	0.65
DEPRESSION	contributes_to	disease	0.60
ALZHEIMER	regulates	disease	0.60
ALZHEIMER'S	regulates	disease	0.60
BDNF	regulates	gene	0.58
ALZHEIMER'S DISEASE	regulates	disease	0.58
ALZHEIMER'S DISEASE	associated_with	disease	0.48
PARKINSON'S DISEASE	associated_with	disease	0.48
TAU	regulates	protein	0.48
MICROGLIA	associated_with	cell_type	0.48
PARKINSON'S DISEASE	mediates	disease	0.48
MICROGLIAL ACTIVATION	associated_with	phenotype	0.45
OXIDATIVE STRESS	associated_with	phenotype	0.45
COGNITIVE DECLINE	associated_with	phenotype	0.45
SYNAPTIC PLASTICITY	associated_with	phenotype	0.45
MITOCHONDRIAL DYSFUNCTION	associated_with	phenotype	0.45
PROGRESSIVE SUPRANUCLEAR PALSY	associated_with	disease	0.45
FRONTOTEMPORAL DEMENTIA	associated_with	disease	0.45
HIPPOCAMPUS	co_discussed	brain_region	0.40
HYPOTHALAMUS	co_discussed	brain_region	0.40
DEMENTIA	co_discussed	disease	0.40
BRAINSTEM	co_discussed	brain_region	0.40
DEPRESSION	regulates	disease	0.35
DEPRESSION	implicated_in	disease	0.35
HYPOTHALAMUS	expressed_in	brain_region	0.35
HIPPOCAMPUS	expressed_in	brain_region	0.35
HIPPOCAMPUS	activates	brain_region	0.35
HIPPOCAMPUS	regulates	brain_region	0.35
CORTEX	regulates	brain_region	0.35
ALPHA-SYNUCLEIN	regulates	gene	0.35
DEMENTIA	regulates	disease	0.35
BRAINSTEM	depletes	brain_region	0.35

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Locus Coeruleus-Hippocampal Circuit Protection	0.480	neuroscience	Circuit-level neural dynamics in neurode

Mentioning Analyses (1)

Scientific analyses that reference this entity

What signals trigger microglia to specifically recognize and phagocytose LC axon

neuroinflammation | 2026-04-14 | 0 hypotheses

Related Papers (15)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year
Predicting onset of symptomatic Alzheimer's disease with plasma p-tau217 clocks. [PMID:41714746]	["Petersen Kellen K", "Mil\u00e0-Alom\u0	Nature medicine	2026
A minimally invasive dried blood spot biomarker test for the detection of Alzhei [PMID:41491101]	Huber H, Montoliu-Gaya L, Brum WS, Vávra	Nat Med	2026
Plasma pTau 217/β-amyloid 1-42 ratio for enhanced accuracy and reduced uncertain [PMID:41562409]	Benina N, Buitrago L, De Simone FI, Radw	Brain	2026
Experimental and translational models of Alzheimer's disease: From neurodegenera [PMID:41619411]	Khan N, De S, Boddu S, Pravala N	J Prev Alzheimers Dis	2026
TP53/TAU axis regulates microtubule bundling to control alveolar stem cell-media [PMID:41642658]	Konishi S, Enkhbayar K, Liu S, Miyashita	J Clin Invest	2026
Spontaneous tauopathy with parkinsonism in an aged cynomolgus macaque. [PMID:41695270]	Takahashi M, Taniguchi D, Funayama M, Ci	Front Aging Neurosci	2026
Differential genome-wide association analysis of schizophrenia and post-traumati [PMID:41767305]	Cheng ZS	Front Genet	2026
Genetic architecture of plasma pTau217 and related biomarkers in Alzheimer's dis [PMID:41804841]	Kim JP, Song M, Cho M, Lee H, Jung SH et	Alzheimers Dement	2026
Shared genetic architecture between Parkinson's disease and self-reported sleep- [PMID:41822813]	Aguilar-Roldán A, Ogonowski NS, Rentería	Sleep Adv	2026
Astroglial and Neuronal Injury Markers (GFAP, UCHL-1, NfL, Tau, S100B) as Diagno [PMID:41828591]	Ogłodek EA, Bar M	Int J Mol Sci	2026
CRISPR-Cas9 and next-generation gene editing strategies for therapeutic interven [PMID:41931258]	Khan MS, Zafar I, Jamal A, Bahwerth FS,	Acta Neurol Belg	2026
Alzheimer's disease basics: we all should know. [PMID:40639927]	Das S	Neurological research	2026
Progressive Supranuclear Palsy-A Global Review. [PMID:40898879]	Kukkle PL, Neupane R, Pantelyat A, Wills	Movement disorders clinical pr	2026
NAD+ restores proteostasis through splicing-dependent autophagy. [PMID:41313318]	Ai R, Fang EF	Autophagy	2026
Viral and non-viral cellular therapies for neurodegeneration. [PMID:41585268]	["Srivastav Jyotsna", "Sharma Sachin"]	Frontiers in medicine	2025

LOCUS COERULEUS

Understanding Entity Pages

Wiki Pages (20)

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

Sleep and Circadian Dysfunction in Alzheimer's Disease

Alpha-Synuclein Pathology

Corticobasal Degeneration (CBD)

Synucleinopathy Mechanism

AI and Machine Learning in Neurodegeneration

Melatonin for Tauopathy: Comprehensive Evidence Synthesis

protective-strategies-cbs-psp

substantia-nigra

Alpha-Synuclein Prion-Like Spreading Mechanisms in Parkinson's Disease

Spinal Cord Stimulation-Affected Neurons

Amyloid Cascade Pathway

Locus Coeruleus Alpha Neurons

proteasome-ubiquitin-system-dysfunction-parkinsons

Pedunculopontine Nucleus Cholinergic Neurons in Neurodegeneration

Braak Staging and Tau Propagation Pathway

rapamycin-tauopathy

SNCA→Alpha-synuclein→Aggregation→Lewy Bodies→Synucleinopathies Causal Chain

Deep Cerebellar Nuclear Neurons