disease

FRONTOTEMPORAL DEMENTIA

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about FRONTOTEMPORAL DEMENTIA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

2122Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

No summary available yet. View on Wiki →

Disease Info

Associated Genes	JUN, UBIQUITIN, TAU, SOD1, TARDBP, FUS, SQSTM1, TREM2
KG Connections	676 knowledge graph edges
Databases	OMIM Orphanet ClinicalTrials PubMed

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    FRONTOTEMPORAL_DEMENTIA["FRONTOTEMPORAL DEMENTIA"] -->|"activates"| STEM_CELLS["STEM CELLS"]
    style STEM_CELLS fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    FRONTOTEMPORAL_DEMENTIA["FRONTOTEMPORAL DEMENTIA"] -->|"activates"| IPSC["IPSC"]
    style IPSC fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    FRONTOTEMPORAL_DEMENTIA["FRONTOTEMPORAL DEMENTIA"] -->|"interacts"| TDP_43["TDP-43"]
    style TDP_43 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    FRONTOTEMPORAL_DEMENTIA["FRONTOTEMPORAL DEMENTIA"] -->|"interacts"| NEURON["NEURON"]
    style NEURON fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    FRONTOTEMPORAL_DEMENTIA["FRONTOTEMPORAL DEMENTIA"] -->|"activates"| ULK1["ULK1"]
    style ULK1 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    FRONTOTEMPORAL_DEMENTIA["FRONTOTEMPORAL DEMENTIA"] -->|"activates"| MITOCHONDRIA["MITOCHONDRIA"]
    style MITOCHONDRIA fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    FRONTOTEMPORAL_DEMENTIA["FRONTOTEMPORAL DEMENTIA"] -->|"activates"| RAPAMYCIN["RAPAMYCIN"]
    style RAPAMYCIN fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    ALS["ALS"] -->|"associated"| FRONTOTEMPORAL_DEMENTIA["FRONTOTEMPORAL DEMENTIA"]
    style ALS fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] -->|"associated"| FRONTOTEMPORAL_DEMENTIA["FRONTOTEMPORAL DEMENTIA"]
    style ALZHEIMER_S_DISEASE fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    PARKINSON_S_DISEASE["PARKINSON'S DISEASE"] -->|"associated"| FRONTOTEMPORAL_DEMENTIA["FRONTOTEMPORAL DEMENTIA"]
    style PARKINSON_S_DISEASE fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    NEURODEGENERATION["NEURODEGENERATION"] -->|"associated"| FRONTOTEMPORAL_DEMENTIA["FRONTOTEMPORAL DEMENTIA"]
    style NEURODEGENERATION fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    TARDBP["TARDBP"] -->|"associated"| FRONTOTEMPORAL_DEMENTIA["FRONTOTEMPORAL DEMENTIA"]
    style TARDBP fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    style FRONTOTEMPORAL_DEMENTIA fill:#ef5350,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (496)

Target	Relation	Type	Str
STEM CELLS	activates	cell_type	0.95
IPSC	activates	cell_type	0.95
TDP-43	interacts_with	gene	0.95
NEURON	interacts_with	cell_type	0.95
TDP-43	regulates	gene	0.80
NEURONS	causes_injury_to	cell_type	0.80
TDP-43	expressed_in	gene	0.65
NEURON	expressed_in	cell_type	0.65
GBA	causes	gene	0.65
HIF1A	causes	gene	0.65
LC3	interacts_with	gene	0.65
MAPK	activates	gene	0.65
OPTN	activates	gene	0.65
P62	activates	gene	0.65
PARKIN	activates	gene	0.65
PARKINSON	activates	disease	0.65
PINK1	activates	gene	0.65
SQSTM1	activates	gene	0.65
STING	activates	gene	0.65
UBIQUITIN	activates	gene	0.65
MTOR	interacts_with	gene	0.65
PINK1	interacts_with	gene	0.65
RAPAMYCIN	interacts_with	drug	0.65
TARDBP	interacts_with	gene	0.65
TFEB	interacts_with	gene	0.65
VCP	activates	gene	0.65
HTT	associated_with	gene	0.65
LC3	causes	gene	0.65
P62	interacts_with	gene	0.65
SQSTM1	interacts_with	gene	0.65
NEURONS	causes	cell_type	0.65
FTD	regulates	disease	0.65
FUS	interacts_with	gene	0.65
FTD	expressed_in	disease	0.65
PARKIN	treats	gene	0.65
PARKINSON	treats	disease	0.65
PARKINSON'S DISEASE	treats	disease	0.65
NEURODEGENERATION	causes	disease	0.65
GRN	causes	gene	0.65
GLUTAMATERGIC	causes	cell_type	0.65
MAPT	causes	gene	0.65
TAU	causes	gene	0.65
FTD	phosphorylates	disease	0.65
NEURON	phosphorylates	cell_type	0.65
NEURONS	phosphorylates	cell_type	0.65
TAU	phosphorylates	gene	0.65
TAU	biomarker_for	gene	0.65
NOTCH	associated_with	gene	0.65
PARKIN	biomarker_for	gene	0.65
PARKINSON	biomarker_for	disease	0.65

Incoming (1626)

Source	Relation	Type	Str
ALS	associated_with	disease	1.00
ALS	activates	disease	1.00
ALZHEIMER'S DISEASE	associated_with	disease	1.00
PARKINSON'S DISEASE	associated_with	disease	1.00
TAU	associated_with	protein	1.00
TARDBP	associated_with	gene	1.00
ALS	causes	disease	1.00
ALS	interacts_with	disease	0.98
SOD1	associated_with	gene	0.90
FUS	associated_with	gene	0.90
MICROGLIA	associated_with	cell_type	0.82
MAPT	associated_with	gene	0.82
AMYLOID	associated_with	protein	0.82
ALS	implicated_in	disease	0.80
ALS	expressed_in	disease	0.80
ASTROCYTES	implicated_in	cell_type	0.80
ALZHEIMER'S DISEASE	activates	disease	0.74
MAPT	causes	gene	0.74
ASTROCYTES	associated_with	cell_type	0.72
BASAL GANGLIA	causes	brain_region	0.70
TNF	associated_with	gene	0.66
TAU	causes	protein	0.66
ALZHEIMER'S DISEASE	contributes_to	disease	0.65
ALS	depletes	disease	0.65
CORTEX	activates	brain_region	0.65
ALZHEIMER'S DISEASE	interacts_with	disease	0.65
ATP	activates	gene	0.65
BCL2	regulates	gene	0.65
ENDOTHELIAL	degrades	cell_type	0.65
ALS	treats	disease	0.65
AMYOTROPHIC LATERAL SCLEROSIS	transports	disease	0.65
ATAXIA	transports	disease	0.65
ATG7	transports	gene	0.65
AMYOTROPHIC LATERAL SCLEROSIS	exacerbates	disease	0.65
ATAXIA	exacerbates	disease	0.65
DEMENTIA	exacerbates	disease	0.65
ALZHEIMER	treats	disease	0.65
ALZHEIMER'S DISEASE	treats	disease	0.65
ALZHEIMER'S DISEASE	causes	disease	0.65
ALZHEIMER	biomarker_for	disease	0.65
ALZHEIMER'S DISEASE	biomarker_for	disease	0.65
TDP-43	treats	gene	0.65
ENDOSOMAL SORTING	interacts_with	pathway	0.65
GRN	encodes	gene	0.65
TMEM106B	increases_risk	gene	0.65
TMEM106B	regulates	gene	0.65
TMEM106B	treats	gene	0.65
MICROGLIA	interacts_with	cell_type	0.65
VCP	degrades	gene	0.65
NEURON	treats	cell_type	0.65

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

FRONTOTEMPORAL DEMENTIA

Understanding Entity Pages

Wiki Pages (20)

Personalized Treatment Plan — Atypical Parkinsonism (CBS/PSP)

Progressive Supranuclear Palsy (PSP)

Corticobasal Syndrome (CBS)

Novel Therapy Index

primary-progressive-aphasia

calcium-dysregulation-comparison

Corticobasal Degeneration (CBD)

Therapeutics

Neurons — Cell Type Hierarchy