Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about CYTOKINES: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
CYTOKINES is a concept in neurodegeneration research. Key relationships include: activates, inhibits, therapeutic target. Associated with ALS, Aging, Als. Connected to 2296 entities in the SciDEX knowledge graph.
| Name | CYTOKINES |
| Key Genes/Proteins | INFLAMMATION, PROINFLAMMATORY CYTOKINES, NF-ΚB |
| Related Diseases | Inflammation, Als, Tumor, Autoimmune, Cancer |
| Related Pathways | Nf-Κb |
Knowledge base pages for this entity
graph TD
subgraph Pathology["Pathology"]
CYTOKINES["CYTOKINES"] -->|"associated with"| INFLAMMATION["INFLAMMATION"]
end
subgraph Signaling["Signaling"]
CYTOKINES["CYTOKINES"] -->|"activates"| PROINFLAMMATORY_CYTOKINES["PROINFLAMMATORY CYTOKINES"]
CYTOKINES["CYTOKINES"] -->|"activates"| Tumor["Tumor"]
NEURODEGENERATION["NEURODEGENERATION"] -->|"activates"| CYTOKINES["CYTOKINES"]
PI3K["PI3K"] -->|"activates"| CYTOKINES["CYTOKINES"]
PI3K_2["PI3K"] -.->|"inhibits"| CYTOKINES["CYTOKINES"]
CANCER["CANCER"] -->|"regulates"| CYTOKINES["CYTOKINES"]
ERK["ERK"] -->|"activates"| CYTOKINES["CYTOKINES"]
end
subgraph Therapeutic["Therapeutic"]
CYTOKINES["CYTOKINES"] -->|"therapeutic target"| INFLAMMATION_1["INFLAMMATION"]
CYTOKINES["CYTOKINES"] -->|"therapeutic target"| NF__B["NF-KappaB"]
CYTOKINES["CYTOKINES"] -->|"therapeutic target"| Inflammation["Inflammation"]
CYTOKINES["CYTOKINES"] -->|"therapeutic target"| Als["Als"]
CYTOKINES["CYTOKINES"] -->|"therapeutic target"| Autoimmune["Autoimmune"]
CYTOKINES["CYTOKINES"] -->|"therapeutic target"| Nf__b["Nf-Kappab"]
PI3K_3["PI3K"] -->|"therapeutic target"| CYTOKINES["CYTOKINES"]
end
style CYTOKINES fill:#90a4ae,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0,font-weight:bold
style INFLAMMATION fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style PROINFLAMMATORY_CYTOKINES fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style INFLAMMATION_1 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style NF__B fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style Inflammation fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style Als fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style Tumor fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style Autoimmune fill:#ef5350,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style Nf__b fill:#1b5e20,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style NEURODEGENERATION fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style PI3K fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style PI3K_2 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style CANCER fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style ERK fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0
style PI3K_3 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:1px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| INFLAMMATION | associated_with | gene | 1.00 |
| PROINFLAMMATORY CYTOKINES | activates | gene | 1.00 |
| INFLAMMATION | therapeutic_target | gene | 1.00 |
| NF-ΚB | therapeutic_target | gene | 1.00 |
| Inflammation | therapeutic_target | disease | 1.00 |
| Als | therapeutic_target | disease | 1.00 |
| Tumor | activates | disease | 1.00 |
| Autoimmune | therapeutic_target | disease | 1.00 |
| Nf-Κb | therapeutic_target | pathway | 1.00 |
| INFLAMMATION | inhibits | gene | 1.00 |
| NF-ΚB | inhibits | gene | 1.00 |
| Inflammation | inhibits | disease | 1.00 |
| Cancer | inhibits | disease | 1.00 |
| Tumor | inhibits | disease | 1.00 |
| Nf-Κb | inhibits | pathway | 1.00 |
| PROINFLAMMATORY CYTOKINES | inhibits | gene | 1.00 |
| MITOCHONDRIAL DYSFUNCTION | activates | gene | 1.00 |
| AUTOPHAGY | activates | gene | 1.00 |
| NEUROINFLAMMATION | activates | gene | 1.00 |
| Als | activates | disease | 1.00 |
| Neuroinflammation | activates | disease | 1.00 |
| Inflammation | activates | disease | 1.00 |
| Autophagy | activates | pathway | 1.00 |
| AKT | activates | gene | 1.00 |
| Neurodegeneration | activates | disease | 1.00 |
| Mtor | activates | pathway | 1.00 |
| AKT | inhibits | gene | 1.00 |
| NF-ΚB | activates | gene | 1.00 |
| Nf-Κb | activates | pathway | 1.00 |
| Mapk | activates | pathway | 1.00 |
| ASTROCYTES | activates | gene | 1.00 |
| INFLAMMATION | activates | gene | 1.00 |
| Alzheimer | activates | disease | 1.00 |
| Als | expressed_in | disease | 1.00 |
| Phagocytosis | activates | pathway | 1.00 |
| Mitophagy | activates | pathway | 1.00 |
| IL-6 | inhibits | gene | 1.00 |
| TNF-Α | inhibits | gene | 1.00 |
| Als | inhibits | disease | 1.00 |
| INFLAMMATION | regulates | gene | 1.00 |
| NF-ΚB | regulates | gene | 1.00 |
| IL-6 | activates | gene | 1.00 |
| NEUROINFLAMMATION | regulates | gene | 1.00 |
| TNF-Α | activates | gene | 1.00 |
| Inflammation | regulates | disease | 1.00 |
| Neuroinflammation | regulates | disease | 1.00 |
| Nf-Κb | regulates | pathway | 1.00 |
| Apoptosis | activates | pathway | 1.00 |
| Immune Response | activates | pathway | 1.00 |
| Oxidative Stress | activates | pathway | 1.00 |
| Source | Relation | Type | Str |
|---|---|---|---|
| NEURODEGENERATION | activates | gene | 1.00 |
| PI3K | activates | gene | 1.00 |
| PI3K | inhibits | gene | 1.00 |
| CANCER | regulates | gene | 1.00 |
| ERK | activates | gene | 1.00 |
| PI3K | therapeutic_target | gene | 1.00 |
| PARKINSON'S DISEASE | activates | gene | 1.00 |
| STAT3 | activates | gene | 1.00 |
| NLRP3 | activates | gene | 1.00 |
| NEURODEGENERATION | therapeutic_target | gene | 1.00 |
| CANCER | therapeutic_target | gene | 1.00 |
| ALZHEIMER | activates | gene | 1.00 |
| INFLAMMATION | activates | gene | 1.00 |
| PARKINSON | activates | gene | 1.00 |
| INFLAMMATION | associated_with | gene | 1.00 |
| INFLAMMATION | regulates | gene | 1.00 |
| TNF | activates | gene | 1.00 |
| APOPTOSIS | activates | gene | 1.00 |
| OXIDATIVE STRESS | activates | gene | 1.00 |
| APOPTOSIS | inhibits | gene | 1.00 |
| TNF | inhibits | gene | 1.00 |
| NEURODEGENERATION | implicated_in | gene | 1.00 |
| ROS | activates | gene | 1.00 |
| NEUROTOXICITY | activates | gene | 1.00 |
| INFLAMMATION | therapeutic_target | gene | 1.00 |
| MITOPHAGY | activates | gene | 1.00 |
| NEURODEGENERATION | regulates | gene | 1.00 |
| COMPLEMENT | activates | gene | 1.00 |
| PYROPTOSIS | activates | gene | 1.00 |
| EXERCISE | activates | gene | 1.00 |
| ROS | inhibits | gene | 1.00 |
| TNF | expressed_in | gene | 1.00 |
| NLRP3 | inhibits | gene | 1.00 |
| TNF | regulates | gene | 1.00 |
| APOPTOSIS | therapeutic_target | gene | 1.00 |
| Tetrahydroxy Stilbene Glucoside | suppresses | compound | 0.90 |
| BAX | inhibits | gene | 0.90 |
| PARKINSON'S DISEASE | therapeutic_target | gene | 0.90 |
| ERK | therapeutic_target | gene | 0.90 |
| CANCER | activates | gene | 0.90 |
| TLR4 | activates | gene | 0.90 |
| MIRNAS | regulates | gene | 0.90 |
| CANCER | associated_with | gene | 0.90 |
| PI3K | regulates | gene | 0.90 |
| STROKE | activates | gene | 0.90 |
| PROINFLAMMATORY CYTOKINES | activates | gene | 0.90 |
| INFLAMMATION | inhibits | gene | 0.90 |
| DEMENTIA | activates | gene | 0.90 |
| TNF | associated_with | gene | 0.90 |
| AUTOPHAGY | activates | gene | 0.90 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
neurodegeneration | 2026-04-04 | 7 hypotheses Top: 0.498
neurodegeneration | 2026-04-04 | 0 hypotheses
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||