What determines the specificity of OPTN's recognition of active Rab8a versus other GTP-bound Rab proteins?

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While the study reveals OPTN selectively recognizes GTP-bound Rab8a through a unique binding mode, the molecular determinants of this specificity remain unclear. This specificity mechanism could inform understanding of vesicular trafficking defects in neurodegeneration. Gap type: unexplained_observation Source paper: Molecular Basis of the Recognition of the Active Rab8a by Optineurin. (2024, Journal of molecular biology, PMID:39374890)

Priority: 0.82 Domain: neurodegeneration Hypotheses: 0
📊 Landscape Analysis

Landscape Summary: What determines the specificity of OPTN's recognition of active Rab8a versus other GTP-bound Rab proteins? is a 0.82 priority gap in neurodegeneration. It has 0 linked hypotheses with average composite score 0.000. Status: open.

Key Unanswered Questions

Key Researchers

Colonna, Sevlever, et al. (TREM2 biology)

Clinical Trials

What determines the specificity of OPTN's recognition of active Rab8a versus other GTP-bound Rab proteins? — INVOKE-2 (completed)

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Hypotheses
0.000
Top Score
0.000
Avg Score
0
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0.00
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🌊 Knowledge Graph Connections

activates (13)

OPTNAlsOPTNMitophagyOPTNInflammationOPTNAutophagyINFLAMMATIONOPTN
▸ Show 8 more

associated with (17)

OPTNAlsOPTNAmyotrophic Lateral SclerosisOPTNAMYOTROPHIC LATERAL SCLEROSISOPTNAutophagyAMYOTROPHIC LATERAL SCLEROSISOPTN
▸ Show 12 more

encodes (1)

OPTNOPTN

inhibits (1)

OPTNAutophagy

interacts with (4)

OPTNAlsOPTNTRAK1/KIF5BOPTNTRAK1USP25OPTN

involved in (1)

OPTNLipophagy

maintains (1)

OPTNmitochondrial homeostasis

mediates (3)

OPTNUbiquitin-Dependent MitophagyOPTNMitophagyOPTNAxonal Mitochondrial Transport

modulates (1)

OPTNvesicle trafficking

promotes (2)

OPTNNLRP3 degradationRab8alipid droplet-mitochondrion interaction

protects against (1)

OPTNDrug-Induced Liver Injury

regulates (4)

OPTNNf-ΚbOPTNAnterograde Axonal Mitochondrial TransportOPTNinflammatory signallingOPTNAls

therapeutic target (1)

OPTNdiabetic cardiomyopathy
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