protein

OPTINEURIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about OPTINEURIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

1232Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

OPTINEURIN is a protein involved in neurodegeneration research. Key relationships include: interacts with, associated with, activates. Associated with ALS, Aging, Alzheimer. Connected to 396 entities in the SciDEX knowledge graph.

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🔬 Protein Info

Gene Symbol	OPTINEURIN
Chromosome	10p13
Protein Family	Selective autophagy receptors (SQSTM1-like)
Protein Type	Adaptor Protein
Function	The UBAN domain recognizes ubiquitin chains on mitochondria, while the LIR motif recruits autophagosomes.
Molecular Weight	~67 kDa
Amino Acids	577
Pathways	Amyloid, Autophagy, Myelination, Necroptosis, Oxidative Stress
UniProt ID	Q96CV9
GeneCards	OPTINEURIN
Human Protein Atlas	OPTINEURIN
Associated Diseases	Als, Alzheimer, Amyotrophic Lateral Sclerosis, Dementia, Frontotemporal Dementia
Interactions	ABCD3, ACTB, Actin, Akt, AKT1, AKT1S1
KG Connections	1230 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

🔮 Predicted Structure: OPTINEURIN — AlphaFold Q96CV9 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

Optineurin

protein · 2027 words

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Pathway Diagram

flowchart TD
    OPTINEURIN(["OPTINEURIN"])
    ULK1(["ULK1"])
    PINK1(["PINK1"])
    Amyotrophic_Lateral_Sclerosis["Amyotrophic Lateral Sclerosis"]
    ALS["ALS"]
    Dementia["Dementia"]
    Alzheimer["Alzheimer"]
    Frontotemporal_Dementia["Frontotemporal Dementia"]
    Cardiovascular["Cardiovascular"]
    Parkinson["Parkinson"]
    Fibrosis["Fibrosis"]
    Cancer["Cancer"]
    Tumor["Tumor"]

    OPTINEURIN -->|"recruits"| ULK1
    PINK1 -->|"recruits"| OPTINEURIN
    OPTINEURIN -->|"interacts with"| Amyotrophic_Lateral_Sclerosis
    OPTINEURIN -->|"interacts with"| ALS
    OPTINEURIN -->|"interacts with"| Dementia
    OPTINEURIN -->|"interacts with"| Alzheimer
    OPTINEURIN -->|"interacts with"| Frontotemporal_Dementia
    OPTINEURIN -->|"interacts with"| Cardiovascular
    OPTINEURIN -->|"interacts with"| Parkinson
    OPTINEURIN -->|"interacts with"| Fibrosis
    OPTINEURIN -->|"interacts with"| Cancer
    OPTINEURIN -->|"associated with"| Tumor
    OPTINEURIN -->|"associated with"| Parkinson
    OPTINEURIN -->|"associated with"| ALS
    OPTINEURIN -->|"associated with"| Frontotemporal_Dementia

    style OPTINEURIN fill:#006494,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (695)

Target	Relation	Type	Str
MITOPHAGY	mediates	process	0.90
ULK1	recruits	protein	0.72
Rheumatoid Arthritis	associated_with	disease	0.65
Inflammation	regulates	disease	0.65
Parkinson	activates	disease	0.65
Hypertension	activates	disease	0.65
Als	associated_with	disease	0.65
Senescence	associated_with	disease	0.65
Alzheimer	associated_with	disease	0.65
Inflammation	degrades	disease	0.65
Alzheimer	activates	disease	0.65
Als	activates	disease	0.65
Fibrosis	interacts_with	disease	0.65
Tumor	associated_with	disease	0.65
Parkinson	associated_with	disease	0.65
Cancer	interacts_with	disease	0.65
Amyotrophic Lateral Sclerosis	associated_with	disease	0.65
Glaucoma	associated_with	disease	0.65
Infection	inhibits	disease	0.65
Alzheimer	expressed_in	disease	0.65
Alzheimer	degrades	disease	0.65
Amyotrophic Lateral Sclerosis	expressed_in	disease	0.65
Huntington	expressed_in	disease	0.65
Dementia	interacts_with	disease	0.65
ALS	interacts_with	disease	0.65
Amyotrophic Lateral Sclerosis	interacts_with	disease	0.65
Tumor	regulates	disease	0.65
ALS	activates	disease	0.65
ALS	regulates	disease	0.65
Ms	activates	disease	0.65
Neurodegeneration	interacts_with	disease	0.65
Dementia	causes	disease	0.65
Inflammation	causes	disease	0.65
Neuroinflammation	inhibits	disease	0.65
Inflammation	inhibits	disease	0.65
Aging	activates	disease	0.65
Neuroinflammation	causes	disease	0.65
Als	causes	disease	0.65
Ataxia	expressed_in	disease	0.65
Frontotemporal Dementia	associated_with	disease	0.65
Glaucoma	regulates	disease	0.65
Neurodegeneration	causes	disease	0.65
Cardiovascular	activates	disease	0.65
Ms	associated_with	disease	0.65
Ftd	causes	disease	0.65
Cancer	regulates	disease	0.65
Frontotemporal Dementia	causes	disease	0.65
Amyotrophic Lateral Sclerosis	causes	disease	0.65
Spinocerebellar Ataxia	expressed_in	disease	0.65
Ischemia	inhibits	disease	0.65

Incoming (537)

Source	Relation	Type	Str
TBK1	binds	protein	0.90
TBK1	phosphorylates	protein	0.85
PINK1	recruits	protein	0.72
C9ORF72	interacts_with	gene	0.60
DDIT3	phosphorylates	entity	0.60
P62	interacts_with	gene	0.60
FUS	interacts_with	gene	0.60
UBIQUITIN	interacts_with	gene	0.60
RB1	interacts_with	gene	0.60
OPTN	interacts_with	gene	0.60
ACTB	interacts_with	gene	0.60
CALCOCO2	interacts_with	gene	0.60
NBR1	interacts_with	gene	0.60
ULK1	interacts_with	gene	0.60
TAX1BP1	interacts_with	gene	0.60
BCL2L11	interacts_with	gene	0.60
SQSTM1	interacts_with	gene	0.60
NLRP3	interacts_with	gene	0.60
XBP1	activates	gene	0.60
MYO7A	activates	gene	0.60
UBIQUITIN	activates	gene	0.60
ATF3	activates	gene	0.60
OPTN	activates	gene	0.60
PRKN	activates	gene	0.60
HSPD1	activates	gene	0.60
TOMM20	activates	gene	0.60
FOXO3	activates	gene	0.60
HSP60	activates	gene	0.60
PARKIN	activates	gene	0.60
EIF2AK3	activates	entity	0.60
IRF3	inhibits	gene	0.60
OPTN	therapeutic_target	gene	0.60
LC3	interacts_with	gene	0.60
DEPTOR	phosphorylates	entity	0.60
EGF	phosphorylates	entity	0.60
EGFR	phosphorylates	entity	0.60
EIF2A	phosphorylates	entity	0.60
EIF2AK3	phosphorylates	entity	0.60
ERN1	phosphorylates	entity	0.60
FIP200	phosphorylates	entity	0.60
GABARAP	phosphorylates	entity	0.60
GRB2	phosphorylates	entity	0.60
HMGB1	phosphorylates	entity	0.60
HSP70	phosphorylates	entity	0.60
HSPA5	phosphorylates	entity	0.60
IFNG	phosphorylates	entity	0.60
JNK	phosphorylates	entity	0.60
LRRK2	phosphorylates	entity	0.60
MAP1LC3A	phosphorylates	entity	0.60
CREBBP	activates	entity	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity