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Why do only 3-4% of MSP1 patients develop parkinsonism despite carrying the same VCP mutations?

OPEN

The rarity of parkinsonism in MSP1 suggests additional factors determine phenotypic expression beyond VCP mutation alone. Identifying these modifying factors could predict which patients will develop parkinsonism and inform personalized treatment approaches. Gap type: unexplained_observation Source paper: In-vivo evidence of synucleinopathy in parkinsonism due to VCP mutation. (2026, Journal of neural transmission (Vienna, Austria : 1996), PMID:40931262)

Priority: 0.74 Domain: neurodegeneration Hypotheses: 0
📊 Landscape Analysis

Landscape Summary: Why do only 3-4% of MSP1 patients develop parkinsonism despite carrying the same VCP mutations? is a 0.74 priority gap in neurodegeneration. It has 0 linked hypotheses with average composite score 0.000. Status: open.

Key Unanswered Questions

Key Researchers

Colonna, Sevlever, et al. (TREM2 biology)

Clinical Trials

Why do only 3-4% of MSP1 patients develop parkinsonism despite carrying the same VCP mutations? — INVOKE-2 (completed)

📈 Living Dashboards
0
Hypotheses
0.000
Top Score
0.000
Avg Score
0
Debates
0.00
Avg Quality
0%
Resolution
0
Mechanistic Families
Gap Resolution Progress0%

Hypothesis Score Distribution

🏆 Competing Hypotheses (Ranked by Score)

No hypotheses linked to this gap yet.

🌊 Knowledge Graph Connections

activates (3)

GRN→VCPGBA→VCPBIN1→VCP

associated with (6)

VCP→FTDVCP→UfmylationVCP→AutophagyVCP→BECN1VCP→OPTN
▸ Show 1 more

causes (8)

VCP→Lysosomal DysfunctionVCP→Immune DysfunctionVCP→Familial ALSVCP→alsVCP→Multisystem Proteinopathy
▸ Show 3 more

degrades (2)

VCP→RPAVCP→RAD51

encodes (1)

VCP→VCP

expresses (2)

FTD→VCPFRONTOTEMPORAL DEMENTIA→VCP

implicated in (2)

VCP→CancerVCP→Neurological Disorders

inhibits (1)

STING→VCP

interacts with (6)

VCP→PIK3C3VCP→BECN1FAF2→VCPAMYOTROPHIC LATERAL SCLEROSIS→VCPMOTOR NEURON→VCP
▸ Show 1 more

involved in (2)

VCP→RNA Stress GranuleVCP→Stress Granule Disassembly

mediates (1)

BECN1→VCP

modulates (1)

UFL1→VCP

regulates (5)

VCP→Autophagosome MaturationVCP→Rna Stress Granule FunctionVCP→Autophagic DegradationATG5→VCPATG7→VCP

risk factor for (1)

VCP→ALS/FTD

stabilizes (4)

VCP→OPTNSTING→VCPFTD→VCPPINK1→VCP

targets (3)

SDA-2026-04-02-gap-tau-prop-20260402003221-H004→VCPh-18a0fcc6→VCPTAU→VCP

therapeutic target (1)

Ufmylation→VCP

upregulates (1)

VCP→GPNMB
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