concept

LYSOSOMAL DYSFUNCTION

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about LYSOSOMAL DYSFUNCTION: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

144Connections

0Hypotheses

2Analyses

23Outgoing

42Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	LYSOSOMAL DYSFUNCTION
Key Genes/Proteins	AMYLOID, TFEB
Related Diseases	INSULIN RESISTANCE, INFLAMMATION, PHAGOCYTOSIS
Linked Hypotheses	1 hypotheses

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    LYSOSOMAL_DYSFUNCTION["LYSOSOMAL DYSFUNCTION"]
    LYSOSOMAL_DYSFUNCTION -->|"causes"| Neurodegenerative_Diseases["Neurodegenerative Diseases"]
    LYSOSOMAL_DYSFUNCTION -->|"contributes to"| LIPID_ACCUMULATION["LIPID ACCUMULATION"]
    LYSOSOMAL_DYSFUNCTION -->|"contributes to"| Parkinson_Disease["Parkinson Disease"]
    LYSOSOMAL_DYSFUNCTION -->|"contributes to"| Insulin_Resistance["Insulin Resistance"]
    LYSOSOMAL_DYSFUNCTION -->|"contributes to"| Lipid_Accumulation["Lipid Accumulation"]
    LYSOSOMAL_DYSFUNCTION -->|"causes"| Lysosomal_Storage_Diseases["Lysosomal Storage Diseases"]
    LYSOSOMAL_DYSFUNCTION -->|"contributes to"| Parkinson_s_Disease["Parkinson's Disease"]
    LYSOSOMAL_DYSFUNCTION -->|"contributes to"| Neurodegeneration["Neurodegeneration"]
    VCP["VCP"] -->|"causes"| LYSOSOMAL_DYSFUNCTION
    Obesity["Obesity"] -->|"causes"| LYSOSOMAL_DYSFUNCTION
    TREM2_p_Q33X_mutation["TREM2 p.Q33X mutation"] -->|"causes"| LYSOSOMAL_DYSFUNCTION
    GBA["GBA"] -->|"regulates"| LYSOSOMAL_DYSFUNCTION
    Cellular_Ageing["Cellular Ageing"] -->|"contributes to"| LYSOSOMAL_DYSFUNCTION
    Autophagy["Autophagy"] -->|"regulates"| LYSOSOMAL_DYSFUNCTION
    TBK1["TBK1"] -.prevents.-> LYSOSOMAL_DYSFUNCTION
    Glycerophosphodiesters["Glycerophosphodiesters"] -->|"correlates_with"| LYSOSOMAL_DYSFUNCTION

Outgoing (55)

Target	Relation	Type	Str
LIPID ACCUMULATION	contributes_to	entity	0.90
INSULIN RESISTANCE	causes	phenotype	0.65
INSULIN RESISTANCE	exacerbates	phenotype	0.65
INSULIN RESISTANCE	inhibits	phenotype	0.65
STEM CELLS	treats	cell_type	0.65
INFLAMMATION	causes	phenotype	0.65
INFLAMMATION	exacerbates	phenotype	0.65
TFEB	regulates	gene	0.65
PERICYTE	causes	cell_type	0.65
MICROGLIA	inhibits	cell_type	0.65
PERICYTE	inhibits	cell_type	0.65
PHAGOCYTOSIS	inhibits	phenotype	0.65
GRN	treats	gene	0.65
SUBSTANTIA NIGRA	implicated_in	brain_region	0.55
PARKINSON'S DISEASE	implicated_in	disease	0.55
INSULIN RESISTANCE	activates	process	0.50
TEMPORAL LOBE	associated_with	brain_region	0.50
AUTOPHAGOSOMES	associated_with	organelle	0.50
EXOSOME	associated_with	organelle	0.45
SUBSTANTIA NIGRA	associated_with	brain_region	0.45
CORTEX	associated_with	brain_region	0.45
NEURODEGENERATION	associated_with	disease	0.45
STRIATUM	associated_with	brain_region	0.45

Incoming (89)

Source	Relation	Type	Str
GBA	regulates	entity	0.90
NEURONS	causes	cell_type	0.70
AMYLOID	protects_against	protein	0.70
EXOSOME	inhibits	organelle	0.65
OBESITY	activates	disease	0.65
TFEB	causes	gene	0.65
MICROGLIA	interacts_with	cell_type	0.65
DOPAMINE	regulates	phenotype	0.65
DOPAMINE	causes	phenotype	0.65
CTSB	regulates	gene	0.65
OLIGODENDROCYTES	activates	cell_type	0.65
ABCA1	causes	gene	0.65
TREM2	exacerbates	gene	0.65
TREM2	activates	gene	0.65
TFEB	exacerbates	gene	0.65
CORTEX	activates	brain_region	0.65
TFEB	treats	gene	0.65
APOE	causes	gene	0.65
GBA	interacts_with	gene	0.65
GBA	increases_risk	gene	0.65
LRRK2	regulates	gene	0.65
TBK1	inhibits	gene	0.65
GBA	encodes	gene	0.65
CHOLESTEROL	regulates	phenotype	0.65
CHOLESTEROL	causes	phenotype	0.65
TMEM106B	inhibits	gene	0.65
MICROGLIA	activates	cell_type	0.65
CERAMIDE	activates	phenotype	0.65
TFEB	interacts_with	gene	0.65
C9orf72	interacts_with	gene	0.65
AMYLOID	transports	protein	0.60
INFLAMMATION	activates	process	0.50
ALPHA-SYNUCLEIN	associated_with	protein	0.50
MICROGLIA	associated_with	cell_type	0.50
ALS	associated_with	disease	0.50
OXIDATIVE STRESS	activates	process	0.50
DEMENTIA	activates	disease	0.50
TAU	upregulates	protein	0.50
TFEB	activates	gene	0.50
STAT3	activates	gene	0.50
RAS	activates	gene	0.50
AUTOPHAGY	activates	process	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (2)

Scientific analyses that reference this entity

Why does autophagy inhibition improve neuronal survival when autophagy is typica

neurodegeneration | 2026-04-15 | 1 hypotheses Top: 0.557